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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">fcmedicine</journal-id><journal-title-group><journal-title xml:lang="ru">Фундаментальная и клиническая медицина</journal-title><trans-title-group xml:lang="en"><trans-title>Fundamental and Clinical Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2500-0764</issn><issn pub-type="epub">2542-0941</issn><publisher><publisher-name>КемГМУ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.23946/2500-0764-2019-4-3-54-60</article-id><article-id custom-type="elpub" pub-id-type="custom">fcmedicine-161</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Беременность и анемия тяжелой степени: проблемы диагностики и лечения</article-title><trans-title-group xml:lang="en"><trans-title>Pregnancy and severe anemia: problems in diagnosis and treatment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4756-6680</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сурина</surname><given-names>М. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Surina</surname><given-names>M. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, доцент кафедры акушерства и гинекологии имени Г.А. Ушаковой, </p><p>650056, г. Кемерово, ул. Ворошилова, д. 22а </p></bio><bio xml:lang="en"><p>MD, PhD, Associate Professor, Department of Obstetrics and Gynecology,</p><p>22a, Voroshilova Street, Kemerovo, 650056</p></bio><email xlink:type="simple">masha_surina@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4121-7188</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чванова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Chvanova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>клинический ординатор кафедры акушерства и гинекологии имени Г.А. Ушаковой;</p><p>врач акушер-гинеколог,</p><p>г. Кемерово</p></bio><bio xml:lang="en"><p>Resident, Department of Obstetrics and Gynecology, 22a, Voroshilova Street, Kemerovo, 650056;</p><p>MD, Obstetrician-Gynecologist, 22, Oktyabr'skiy Prospekt, Kemerovo, 650000</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5641-5246</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Марочко</surname><given-names>Т. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Marochko</surname><given-names>T. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, доцент, кафедра акушерства и гинекологии имени Г.А. Ушаковой,</p><p>г. Кемерово</p></bio><bio xml:lang="en"><p>MD, PhD, Associate Professor, Department of Obstetrics and Gynecology,</p><p>22a, Voroshilova Street, Kemerovo, 650056</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2506-9250</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карелина</surname><given-names>О. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Karelina</surname><given-names>O. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, доцент кафедры акушерства и гинекологии имени Г.А. Ушаковой,</p><p>г. Кемерово</p></bio><bio xml:lang="en"><p>MD, PhD, Associate Professor, Department of Obstetrics and Gynecology,</p><p>22a, Voroshilova Street, Kemerovo, 650056</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Кемеровский государственный медицинский университет» Министерства здравоохранения Российской Федерации, г. Кемерово</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kemerovo State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Кемеровский государственный медицинский университет» Министерства здравоохранения Российской Федерации;&#13;
ГАУЗ КО «Областной клинический перинатальный центр им. Л.А. Решетовой»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kemerovo State Medical University;&#13;
Reshetova Kemerovo Regional Perinatal Center</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБОУ ВО «Кемеровский государственный медицинский университет» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kemerovo State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>30</day><month>09</month><year>2019</year></pub-date><volume>4</volume><issue>3</issue><fpage>52</fpage><lpage>60</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сурина М.Н., Чванова Е.А., Марочко Т.Ю., Карелина О.Б., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Сурина М.Н., Чванова Е.А., Марочко Т.Ю., Карелина О.Б.</copyright-holder><copyright-holder xml:lang="en">Surina M.N., Chvanova E.A., Marochko T.Y., Karelina O.B.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://fcm.kemsmu.ru/jour/article/view/161">https://fcm.kemsmu.ru/jour/article/view/161</self-uri><abstract><sec><title>Цель</title><p>Цель. Изучение особенностей течения, осложнений и исходов беременности и родов у женщин с анемией тяжелой степени.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Проведен анализ 39 историй родов женщин с тяжелой анемией, родоразрешенных в ГАУЗ КО «ОКПЦ им. Л.А. Решетовой» за 2017 и 2018 г.</p></sec><sec><title>Результаты</title><p>Результаты. Средний возраст женщин в исследуемой выборке составил 30 ± 5 лет (возраст начала половой жизни – 17 ± 1 лет). Доля первородящих и курящих женщин составляла 28% и 56% соответственно. По данным соматического анамнеза, до беременности исследуемые женщины в 69% случаев имели хроническую анемию различного генеза и в 21% были ВИЧ-положительными. В среднем первый визит в женскую консультацию регистрировался во втором триместре (14 ± 6 неделя беременности), а 13% женщин не обследовались и не наблюдались в женской консультации в период беременности. Доля преждевременных и срочных родов у женщин с тяжелой анемией составила 31% и 69% соответственно; 80% пациенток нуждались в кесаревом сечении для родоразрешения. Масса новорожденного у таких пациенток составила 2820 ± 805 г. В 28% случаев наблюдалась задержка внутриутробного развития плода. При постановке на учет среднее значение гемоглобина составляло 103±13 г/л, при поступлении в стационар – 74±8 г/л, на момент гемотрансфузии – 65±4 г/л. Уровень сывороточного железа при постановке на учет и при поступлении в стационар составлял 11±5 ммоль/л и 8±3 ммоль/л соответственно. Терапия препаратами железа не была эффективной у 84% получавших ее пациенток (90% от общей выборки).</p></sec><sec><title>Заключение</title><p>Заключение. В большинстве случаев тяжелая анемия развивалась на фоне хронической анемии, возникшей до беременности, что говорит об отсутствии прегравидарной подготовки и обследования до беременности. Кроме того, терапия препаратами железа не способствовала коррекции анемии у данной категории пациенток. Среди осложнений беременности наиболее часто встречалась тяжелая преэклампсия, что увеличивало количество родоразрешений операцией кесарева сечения. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To determine features, course, complications, and outcomes of pregnancy in women with severe anemia.</p></sec><sec><title>Materials and Methods</title><p>Materials and Methods. We retrospectively analysed 39 case histories of women with severe anemia during pregnancy who delivered in Reshetova Kemerovo Regional Perinatal Center during 2017-2018.</p></sec><sec><title>Results</title><p>Results. Average age of women was 30 ± 5 years (average age of sexual debut 17 ± 1 years). The proportions of primiparous and smoking women were 28% and 56%, respectively. More than two-thirds (69%) of women suffered from chronic anemia before the pregnancy, and 21% were HIVinfected. Average first visit to the obstetrician was registered during the second trimester (at 14 ± 6 weeks of gestation), and 13% did not receive the medical care during the pregnancy. The prevalence of preterm and emergency childbirth was 31% and 69%, respectively; 80% of patients required a Cesarean section, and the average birth weight was 2,820 ± 805 g. Intrauterine growth restriction was observed in 28% of cases. Average values of hemoglobin at the first visit, at hospital admission, and at the time of blood transfusion were 103 ± 13 g/L, 74 ± 8 g/L, and 65 ± 4 g/L, respectively; average serum iron at the first visit and at hospital admission was 11 ± 5 µmol/L and 8 ± 3 µmol/L, respectively. Iron replacement therapy was inefficient in 84% of women who received it (90%).</p></sec><sec><title>Conclusion</title><p>Conclusion. In the majority of cases, severe anemia developed from chronic anemia which had occurred before pregnancy and could not be corrected by means of iron replacement therapy. Pregnant women with severe anemia often require Cesarean section due to pre-eclampsia. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>беременность</kwd><kwd>тяжелая анемия</kwd><kwd>дефицит железа</kwd><kwd>препараты железа</kwd><kwd>гемотрансфузия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pregnancy</kwd><kwd>severe anemia</kwd><kwd>iron deficiency</kwd><kwd>iron preparations</kwd><kwd>blood transfusion</kwd><kwd>pre-eclampsia</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">EFFECTIVE transfusion in obstetric practice. In: Transfusion Handbook. 5nd ed. 2014. 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