fcmedicineФундаментальная и клиническая медицинаFundamental and Clinical Medicine2500-07642542-0941КемГМУ10.23946/2500-0764-2019-4-3-83-94fcmedicine-165Research ArticleОБЗОРНЫЕ СТАТЬИREVIEW ARTICLESЭпендимоциты головного мозга в нейрогенезе и регуляции структурно-функциональной целостности гемато-ликворного барьераBrain ependymocytes in neurogenesis and maintaining integrity of blood-cerebrospinal fluid barrierhttps://orcid.org/0000-0002-5714-3462УспенскаяЮ. А.UspenskayaYu. A.

доктор биологических наук, доцент, научный сотрудник;

профессор кафедры внутренних незаразных болезней, акушерства и физиологии сельскохозяйственных животных ,

г. Красноярск

DSc, Associate Professor, Researcher, 1, Partizana Zheleznyaka Street, Krasnoyarsk, 660022;

Professor, Department of Internal Non-Communicable Diseases, Obstetrics and Physiology of Livestock, 90, Prospekt Mira, Krasnoyarsk, 660049

https://orcid.org/0000-0002-9644-5500МоргунА. В.MorgunA. V.

доктор медицинских наук, научный сотрудник,

660022, г. Красноярск, ул. Партизана Железняка, д. 1

MD, DSc, Researcher, Research Institute of Molecular Medicine and Pathobiochemistry,

1, Partizana Zheleznyaka Street, Krasnoyarsk, 660022

441682@mail.ruhttps://orcid.org/0000-0001-9499-076XОсиповаЕ. Д.OsipovaE. D.

научный сотрудник,

г. Красноярск

Researcher, Research Institute of Molecular Medicine and Pathobiochemistry,

1, Partizana Zheleznyaka Street, Krasnoyarsk, 660022

https://orcid.org/0000-0003-4868-1274АнтоноваС К.AntonovaS. K.

старший преподаватель кафедры биологической химии с курсом медицинской, фармацевтической и токсикологической химии,

г. Красноярск

Senior Lecturer, Department of Biological, Medical, Pharmaceutical, and Toxicological Chemistry,

1, Partizana Zheleznyaka Street, Krasnoyarsk, 660022

https://orcid.org/0000-0002-9170-0867СалминаА. Б.SalminaA. B.

доктор медицинских наук, профессор, главный научный сотрудник и руководитель НИИ молекулярной медицины и патобиохимии, заведующая кафедрой биологической химии с курсами медицинской, фармацевтической и токсикологической химии,

г. Красноярск

D, DSc, Head of the Research Institute of Molecular Medicine and Pathobiochemistry, Head of the Department of Biological, Medical, Pharmaceutical, and Toxicological Chemistry, 

1, Partizana Zheleznyaka Street, Krasnoyarsk, 660022

НИИ молекулярной медицины и патобиохимии ФГБОУ ВО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Министерства здравоохранения Российской Федерации; ФГБОУ ВО «Красноярский государственный аграрный университет»РоссияResearch Institute of Molecular Medicine and Pathobiochemistry, Voino-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk State Agrarian UniversityRussian FederationНИИ молекулярной медицины и патобиохимии ФГБОУ ВО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Министерства здравоохранения Российской ФедерацииРоссияResearch Institute of Molecular Medicine and Pathobiochemistry, Voino-Yasenetsky Krasnoyarsk State Medical UniversityRussian Federation201930092019438394Copyright © Успенская Ю.А., Моргун А.В., Осипова Е.Д., Антонова С.К., Салмина А.Б., 20192019Успенская Ю.А., Моргун А.В., Осипова Е.Д., Антонова С.К., Салмина А.Б.Uspenskaya Y.A., Morgun A.V., Osipova E.D., Antonova S.K., Salmina A.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://fcm.kemsmu.ru/jour/article/view/165

Выполнен обзор литературы, посвященный роли эпендимальных клеток головного мозга в центральной нервной системе, в том числе продукции ликвора, регуляции работы нейрогенных ниш и нейрогенеза в физиологических условиях и ряде заболеваний. В обзоре приведены современные данные о роли реснитчатого аппарата эпендимоцитов в обеспечении нормального функционирования этих клеток. Функциональная активность эпендимальных клеток может существенно отличаться в зависимости от их локализации в центральной нервной системе (ЦНС). Изучение роли эпендимоцитов в функционировании головного мозга необходимо для полноценного понимания механизмов неврологических заболеваний и может открыть новые фармакотерапевтические стратегии, ориентированные на коррекцию нейродегенерации и аберрантного развития головного мозга.

Here we review the physiology of brain ependymocytes which produce cerebrospinal fluid, regulate neurogenic niches, and contribute to neurogenesis in health and disease. We particularly focus on cilia as these organelles are pivotal to ensure the normal functioning of ependymocytes. The functional activity of ependymocytes is largely defined by their localisation in the central nervous system. Further studies of ependymal cell biology are required to better understand the mechanisms of neurological disorders and to discover novel therapeutic strategies aimed at correcting neurodegeneration and aberrant development of the brain.

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The authors declare that there are no conflicts of interest present.