fcmedicineФундаментальная и клиническая медицинаFundamental and Clinical Medicine2500-07642542-0941КемГМУ10.23946/2500-0764-2020-5-2-112-118fcmedicine-270Research ArticleОБЗОРНЫЕ СТАТЬИREVIEW ARTICLESПерспективы использования сиалированных иммуноглобулинов в терапии различных заболеванийProspects for the use of sialylated immunoglobulins in the treatment of different diseaseshttps://orcid.org/0000-0002-3781-6340МаркинаЮ. В.MarkinaYu. V.

Маркина Юлия Владимировна - кандидат медицинских наук, научный сотрудник лаборатории инфекционной патологии и молекулярной микроэкологии.

117418, Россия, Москва, ул. Цюрупы, д. 3

Dr. Yulia V. Markina - MD, PhD, Research Fellow, Laboratory of Infectious Pathology and Molecular Microecology.

3, Tsyurupy Street, 117418, Moscow, Russian Federation

https://orcid.org/0000-0002-6649-7924МаркинА. М.MarkinA. M.

Маркин Александр Михайлович - кандидат медицинских наук, научный сотрудник лаборатории инфекционной патологии и молекулярной микроэкологии.

117418, Россия, Москва, ул. Цюрупы, д. 3

Dr. Alexander M. Markin - MD, PhD, Research Fellow, Laboratory of Infectious Pathology and Molecular Microecology.

3, Tsyurupy Street, 117418, Moscow, Russian Federation

alexander.markin.34@gmail.comhttps://orcid.org/0000-0003-0978-6444СобенинИ. А.SobeninI. A.

Собенин Игорь Александрович - доктор медицинских наук, руководитель лаборатории медицинской генетики.

121552, Россия, г. Москва, ул. 3-я Черепковская 15а

Dr. Igor A. Sobenin - MD, DSc, Head of the Laboratory for Medical Genetics.

15A, 3rd Cherepkovskaya Street, 121552, Moscow, Russian Federation

ОреховА. H.OrekhovA. N.

Орехов Александр Николаевич - доктор биологических наук, профессор, заведующий лабораторией ангиопатологии; ведущий научный сотрудник лаборатории инфекционной патологии и молекулярной микроэкологии.

125315, Россия, ул. Балтийская, 8

117418, Россия, Москва, ул. Цюрупы, д. 3

Prof. Alexander N. Orekhov - MD, DSc, Professor, Head of the Laboratory of Angiopathology; Senior Researcher, Laboratory of Infectious Pathology and Molecular Microecology.

8, Baltiyskaya Street, 125315, Moscow, Russian Federation

3, Tsyurupy Street, 117418, Moscow, Russian Federation

ФГБНУ «Научно-исследовательский институт морфологии человека»РоссияResearch Institute of Human MorphologyRussian FederationФГБНУ «Национальный медицинский исследовательский центр кардиологии» Министерства здравоохранения Российской ФедерацииРоссияNational Medical Cardiology Research CenterRussian FederationФГБНУ «Научно-исследовательский институт морфологии человека»; ФГБНУ «Научно-исследовательский институт общей патологии и патофизиологии»РоссияResearch Institute of Human Morphology; Research Institute of Pathology and PathophysiologyRussian Federation20202706202052112118Copyright © Маркина Ю.В., Маркин А.М., Собенин И.А., Орехов А.H., 20202020Маркина Ю.В., Маркин А.М., Собенин И.А., Орехов А.H.Markina Y.V., Markin A.M., Sobenin I.A., Orekhov A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://fcm.kemsmu.ru/jour/article/view/270

Ключевую роль в борьбе с различными патогенами, направленную на выживание клеток и организма в целом играют иммуноглобулины. Данные о центральной роли гликозилирования были подтверждены в ходе многочисленных исследований течения множества заболеваний человека. В частности, изменение профиля гликозилирования антител наблюдается при воспалительных заболеваниях (аутоиммунитет, злокачественные новообразования), а также инфекционных и онкологических заболеваниях. Можно смело утверждать, что анализ гликозилирования антител может стать многообещающим дополнением для совершенствования существующих стратегий диагностики различных заболеваний. В дополнение к этому, специфические изменения молекул гликанов иммуноглобулинов можно использовать в терапии заболеваний различного рода моноклональными антителами, что подчеркивает важную роль гликанов в формировании эффекторной функции антител. Всё это будет способствовать очередному прорыву в области разработки терапевтических препаратов и вакцин следующего поколения.

The central role of glycosylation has been well confirmed in numerous studies. In particular, a change in the glycosylation profile of antibodies is observed in infectious diseases, autoimmune disorders and cancer. The analysis of antibody glycosylation can lead to a promising improvement of existing strategies for the disease diagnosis. Specific changes in immunoglobulin glycan molecules can be used in the targeted therapy of multiple diseases, emphasizing the importance of glycans in antibody effector function. Altogether, use of sialylated immunoglobulins may contribute to the next breakthrough in the development of therapeutic drugs and vaccines of the next generation.

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The authors declare that there are no conflicts of interest present.