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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">fcmedicine</journal-id><journal-title-group><journal-title xml:lang="ru">Фундаментальная и клиническая медицина</journal-title><trans-title-group xml:lang="en"><trans-title>Fundamental and Clinical Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2500-0764</issn><issn pub-type="epub">2542-0941</issn><publisher><publisher-name>КемГМУ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.23946/2500-0764-2021-6-2-66-74</article-id><article-id custom-type="elpub" pub-id-type="custom">fcmedicine-407</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Апробация методики оценки психофизиологического состояния оператора при виртуализации рабочего информационного пространства</article-title><trans-title-group xml:lang="en"><trans-title>Psychophysiological changes during workspace virtualization</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6391-0170</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тарасова</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tarasova</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, ведущий научный сотрудник лаборатории нейрососудистой патологии,</p><p>650002, г. Кемерово, Сосновый бульвар, д. 6</p></bio><bio xml:lang="en"><p>MD, DSc, Leading Researcher, Laboratory of Neurovascular Research, Department of Clinical Cardiology,</p><p>6, Sosnovy Boulevard, Kemerovo, 650002</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8752-1332</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никитенко</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikitenko</surname><given-names>M. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат технических наук, научный сотрудник лаборатории угольного машиностроения,</p><p>650000, г. Кемерово, пр. Советский, д. 18</p></bio><bio xml:lang="en"><p>PhD, Research Fellow, Laboratory of Coal Mining Machinery,</p><p>18, Sovietskiy Prospekt, Kemerovo, 650000</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8260-8033</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трубникова</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Trubnikova</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, заведующая лабораторией нейрососудистой патологии.</p><p>650002, г. Кемерово, Сосновый бульвар, д. 6</p></bio><bio xml:lang="en"><p>MD, DSc, Head of the Laboratory for Neurovascular Research, Department of Clinical Cardiology,</p><p>6, Sosnovy Boulevard, Kemerovo, 650002</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6813-7017</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кухарева</surname><given-names>И. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Kukhareva</surname><given-names>I. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, научный сотрудник лаборатории нейрососудистой патологии,</p><p>650002, г. Кемерово, Сосновый бульвар, д. 6</p></bio><bio xml:lang="en"><p>MD, PhD, Research Fellow, Laboratory for Neurovascular Research, Department of Clinical Cardiology,</p><p>6, Sosnovy Boulevard, Kemerovo, 650002</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9750-5536</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куприянова</surname><given-names>Д. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kupriyanova</surname><given-names>D. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>лаборант-исследователь лаборатории нейрососудистой патологии,</p><p>650002, г. Кемерово, Сосновый бульвар, д. 6</p></bio><bio xml:lang="en"><p>Research Assistant, Laboratory for Neurovascular Research, Department of Clinical Cardiology,</p><p>6, Sosnovy Boulevard, Kemerovo, 650002</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8908-2070</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соснина</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Sosnina</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, научный сотрудник лаборатории нейрососудистой патологии,</p><p>650002, г. Кемерово, Сосновый бульвар, д. 6</p></bio><bio xml:lang="en"><p>MD, PhD, Research Fellow, Laboratory for Neurovascular Research, Department of Clinical Cardiology,</p><p>6, Sosnovy Boulevard, Kemerovo, 650002</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4642-3610</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Барбараш</surname><given-names>О. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Barbarash</surname><given-names>O. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, профессор, член-корреспондент РАН, директор,</p><p>650002, г. Кемерово, Сосновый бульвар, д. 6</p></bio><bio xml:lang="en"><p>MD, DSc, Professor, Corresponding Member of the Russian Academy of Sciences, Chief Executive Officer,</p><p>6, Sosnovy Boulevard, Kemerovo, 650002</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute for Complex Issues of Cardiovascular Diseases</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБНУ «Федеральный исследовательский центр угля и углехимии Сибирского отделения Российской академии наук»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Research Center of Coal and Coal Chemistry</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>01</day><month>07</month><year>2021</year></pub-date><volume>6</volume><issue>2</issue><fpage>66</fpage><lpage>74</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Тарасова И.В., Никитенко М.С., Трубникова О.А., Кухарева И.Н., Куприянова Д.С., Соснина А.С., Барбараш О.Л., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Тарасова И.В., Никитенко М.С., Трубникова О.А., Кухарева И.Н., Куприянова Д.С., Соснина А.С., Барбараш О.Л.</copyright-holder><copyright-holder xml:lang="en">Tarasova I.V., Nikitenko M.S., Trubnikova O.A., Kukhareva I.N., Kupriyanova D.S., Sosnina A.S., Barbarash O.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://fcm.kemsmu.ru/jour/article/view/407">https://fcm.kemsmu.ru/jour/article/view/407</self-uri><abstract><sec><title>Цель</title><p>Цель. Апробация методики оценки психофизиологического состояния оператора при виртуализации рабочего информационного пространства на основе психофизиологических и электроэнцефалографических (ЭЭГ) параметров.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В эксперименте приняли участие 10 практически здоровых мужчин-правшей в возрасте от 25 до 45 лет, у которых оценивалось психофизиологическое состояние до, в процессе и по завершении работы в очках виртуальной реальности (ВР). Все участники имели высшее образование, нормальное или скорректированное до нормального зрение и опыт использования компьютера. Исследование психофизиологического состояния включало в себя неврологический осмотр, расширенное психометрическое тестирование с оценкой уровня функциональной подвижности нервных процессов (УФП) (время реакции, частота ошибок, количество пропущенных сигналов), работоспособности головного мозга (РГМ) в режиме «обратной связи» (время реакции, частота ошибок и пропущенные сигналы), оценку функций внимания (количество обработанных знаков на 1-й и 4-й минуте корректурной пробы Бурдона, объем внимания), кратковременной памяти (запоминание предъявляемых визуально 10 слов, 10 чисел и 10 бессмысленных слогов), пространственного восприятия, а также регистрацию многоканальной компьютерной ЭЭГ в состоянии покоя.</p></sec><sec><title>Результаты</title><p>Результаты. Обнаружено, что ухудшение психометрических показателей после когнитивной нагрузки в ВР наблюдается только в наиболее сложных для выполнения заданиях: количество ошибок возросло на 93% в тесте РГМ и на 65% в тесте распределения внимания. Анализ ЭЭГ-данных показал, что после выполнения заданий в ВР у испытуемых мощность биопотенциалов дельта ритма уменьшилась на 28%, тета1 - на 13%, в то время как альфа1 ритм возрос на 96%. Предполагается, что наблюдаемые ЭЭГ-изменения соответствуют паттернам активации коры головного мозга, связанным с выполнением когнитивной нагрузки и возникающим утомлением.</p></sec><sec><title>Заключение</title><p>Заключение. Разработанная парадигма экспериментального исследования с определением психофизиологического состояния человека до и после работы испытуемых в ВР показала приемлемую субъективную трудность и переносимость ВР согласно психофизиологическим показателями и может быть использована для целевой группы испытуемых. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To estimate psychophysiological changes during workspace virtualization.</p></sec><sec><title>Materials and Methods</title><p>Materials and Methods. We evaluated the psychophysiological profile of 10 healthy right-handed males aged 25 to 45 years before, during and after the working in a virtual reality (VR) headset. All participants had higher education, normal or corrected to normal vision, and were experienced computer users. Psychometric testing included a neurological examination, assessment of functional and feedback-related brain activity (reaction time, errors, and missed signals) and attention span, quantification of processed symbols in the 1st and 4th minutes of Bourdon test, analysis of short-term memory (10 words, 10 numbers and 10 meaningless syllables memorization) and spatial perception, and multi-channel electroencephalography recording in rest.</p></sec><sec><title>Results</title><p>Results. Deterioration of psychometric indicators after a cognitive load in a VR headset was documented only in the most difficult tasks: the number of errors increased by 93% in the brain performance test and by 65% in the attention distribution test. The analysis of electroencephalography data showed that the delta rhythm and theta1 rhythm activity decreased by 28 and 13%, respectively, after working in a VR headset as compared to baseline values, while alpha1 rhythm activity increased by 96%. Probably, the observed electroencephalography changes corresponded to the patterns of brain activation associated with cognitive load and the resulting fatigue.</p></sec><sec><title>Conclusions</title><p>Conclusions. We developed a suitable approach for the psychometric testing before and after working in VR headset, which demonstrated general tolerance and acceptable subjective difficulties to VR load. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>психометрическое тестирование</kwd><kwd>ЭЭГ</kwd><kwd>когнитивная нагрузка</kwd><kwd>виртуальная реальность</kwd><kwd>человеко-машинный интерфейс</kwd><kwd>виртуальное рабочее пространство</kwd></kwd-group><kwd-group xml:lang="en"><kwd>psychometric testing</kwd><kwd>electroencephalography</kwd><kwd>cognitive load</kwd><kwd>virtual reality</kwd><kwd>human-machine interface</kwd><kwd>virtual workspace</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Liao YY, Chen IH, Lin YJ, Chen Y, Hsu WC. 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