fcmedicineФундаментальная и клиническая медицинаFundamental and Clinical Medicine2500-07642542-0941КемГМУfcmedicine-62Research ArticleСтатьиПОЛИОРГАННАЯ НЕДОСТАТОЧНОСТЬ В ПРАКТИКЕ ПЕДИАТРИЧЕСКОЙ РЕАНИМАТОЛОГИИ: ОБНОВЛЕННЫЕ ПАТОФИЗИОЛОГИЯ И ПРОГНОЗMULTIPLE ORGAN FAILURE IN PEDIATRIC CRITICAL CARE: ADVANCES IN PATHOPHYSIOLOGY AND PROGNOSISПетроваЕ. О.PetrovaEVGENIYA O.noemail@neicon.ruГригорьевЕ. В.GrigorievEVGENIY V.noemail@neicon.ruФГБОУ ВО «Кемеровский государственный медицинский университет» Минздрава РоссииРоссияKemerovo State Medical UniversityRussian FederationФГБНУ «НИИ комплексных проблем сердечно-сосудистых заболеваний»РоссияResearch Institute for Complex Issues of Cardiovascular DiseasesRussian Federation201730092017238287Copyright © Петрова Е.О., Григорьев Е.В., 20172017Петрова Е.О., Григорьев Е.В.Petrova E.O., Grigoriev E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://fcm.kemsmu.ru/jour/article/view/62

Полиорганная недостаточность (ПОН) является ведущей причиной госпитализации пациентов в отделения реанимации. Актуальность проблемы связана с сохраняющимся уровнем летальности и финансовым затратами на лечение подобной категории пациентов. В обзоре даются современные представления об уточнениях в механизмах формирования ПОН в педиатрии (инициирующие факторы, фоновая патология, выброс DAMP и PAMP, в том числе и вероятность транслокации бактерий, дисфункции эпителия, эндотелия, митохондрий, иммунологического ответа). Приводятся данные о шкалах прогноза и диагностики ПОН в педиатрии.

Multiple organ failure is a leading cause of admission to the intensive care units, characterized by a high case fatality rate and significant financial costs. Here we review the mechanisms of multiple organ failure in pediatric patients (triggers, concomitant diseases, release of danger- and pathogen-associated molecular patterns, bacterial translocation, epithelial, endothelial, or mitochondrial dysfunction, and inadequate immune response) and recent diagnostic and prognostic scales.

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The authors declare that there are no conflicts of interest present.