References

fcmedicine

Фундаментальная и клиническая медицина

Fundamental and Clinical Medicine

2500-07642542-0941

КемГМУ

10.23946/2500-0764-2023-8-1-132-142

fcmedicine-684

Research Article

ДИСКУССИИ

DISCUSSIONS

Острый коронарный синдром без подъёма сегмента St. Итоги 2021−2022 гг.

Non-ST segment elevation myocardial infarction: results of 2021−2022

https://orcid.org/0000-0002-4642-3610

Барбараш

О. Л.

Barbarash

O. L.

Барбараш Ольга Леонидовна, доктор медицинских наук, профессор, академик РАН, директор

650002, г. Кемерово, Сосновый бульвар, д. 6

Prof. Olga L. Barbarash, MD, DSc, Academician of the Russian Academy of Sciences, Chief Executive Officer

6, Sosnovy Boulevard, Kemerovo, 650002

https://orcid.org/0000-0003-3729-616X

Кашталап

В. В.

Kashtalap

V. V.

Кашталап Василий Васильевич, доктор медицинских наук, заведующий отделом клинической кардиологии

650002, г. Кемерово, Сосновый бульвар, д. 6

Dr. Vasiliy V. Kashtalap, MD, DSc, Head of the Department of Clinical Cardiology

6, Sosnovy Boulevard, Kemerovo, 650002

v_kash@mail.ru

ФГБНУ «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний»РоссияResearch Institute for Complex Issues of Cardiovascular DiseasesRussian Federation

2023

01042023

81132142

2023

Барбараш О.Л., Кашталап В.В.

Barbarash O.L., Kashtalap V.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://fcm.kemsmu.ru/jour/article/view/684

В статье представлен краткий обзор новых согласительных документов и клинических рекомендаций 2021−2022 гг., посвященных ведению пациентов с острым коронарным синдромом (ОКС) без подъёма сегмента ST. Проанализированы статистические показатели по частоте ОКС в Российской Федерации (РФ). Дан экспертный анализ эффектов пандемии новой коронавирусной инфекции на систему оказания медицинской помощи при ОКС в РФ и непосредственного влияния коронавируса на сердечно-сосудистую систему. Представлены новые данные, касающиеся уточнений к четвёртому универсальному определению инфаркта миокарда от 2018 г.

Here we provide a brief overview of current consensus documents and clinical guidelines concerning the management of the patients with acute coronary syndrome (ACS) without ST segment elevation, which have been released in 2021-2022. Further, we consider statistics on ACS in the Russian Federation and discuss an expert analysis of the effects of COVID-19 pandemic on ACS-associated healthcare in Russian Federation, as well as the pathological effects of SARS-CoV-2 on the circulatory system. The fourth universal definition of myocardial infarction (2018) is also clarified according to the recent updates.

острый коронарный синдроминфаркт миокардареваскуляризациякардиомаркерыоценка рискапрогнозновая коронавирусная инфекциядвойная антиагрегантная терапия

acute coronary syndromemyocardial infarctionrevascularisationcardiac markersrisk assessmentprognosisCOVID-19dual antiplatelet therapy

Работа выполнена при поддержке комплексной программы фундаментальных научных исследований СО РАН в рамках фундаментальной темы НИИ КПССЗ № 0419-2022-0002 «Разработка инновационных моделей управления риском развития болезней системы кровообращения с учетом коморбидности на основе изучения фундаментальных, клинических, эпидемиологических механизмов и организационных технологий медицинской помощи в условиях промышленного региона Сибири» (научный руководитель – академик РАН О.Л. Барбараш).

This research was funded by the Complex Program of Basic Research under the Siberian Branch of the Russian Academy of Sciences within the Basic Research Topic of Research Institute for Complex Issues of Cardiovascular Diseases № 0419- 2022-0002 “Development of innovative models for management of cardiovascular disease risk factors and comorbid conditions”.There was no funding for this project.

References1

Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, White HD; Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/ American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction. Fourth universal definition of myocardial infarction (2018). Eur Heart J. 2019;40(3):237-269. https://doi.org/10.1093/eurheartj/ehy462

Collet JP, Thiele H, Barbato E, Barthélémy O, Bauersachs J, Bhatt DL, Dendale P, Dorobantu M, Edvardsen T, Folliguet T, Gale CP, Gilard M, Jobs A, Jüni P, Lambrinou E, Lewis BS, Mehilli J, Meliga E, Merkely B, Mueller C, Roffi M, Rutten FH, Sibbing D, Siontis GCM; ESC Scientific Document Group. 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J. 2021;42(14):1289-1367. https://doi.org/10.1093/eurheartj/ehaa575

Барбараш О.Л., Дупляков Д.В., Затейщиков Д.А., Панченко Е.П., Шахнович Р.М., Явелов И.С., Яковлев А.Н., Абугов С.А., Алекян Б.Г., Архипов М.В., Васильева Е.Ю., Галявич А.С., Ганюков В.И., Гиляревский С.Р., Голубев Е.П., Голухова Е.З., Грацианский Н.А., Карпов Ю.А., Космачева Е.Д., Лопатин Ю.М., Марков В.А., Никулина Н.Н., Певзнер Д.В., Погосова Н.В., Протопопов А.В., Скрыпник Д.В., Терещенко С.Н., Устюгов С.А., Хрипун А.В., Шалаев С.В., Шпектор А.В., Якушин С.С. Острый коронарный синдром без подъема сегмента ST электрокардиограммы. Клинические рекомендации 2020. Российский кардиологический журнал. 2021;26(4):149-202. https://doi.org/10.15829/1560-4071-2021-4449

Barbarash OL, Duplyakov DV, Zateischikov DA, Panchenko EP, Shakhnovich RM, Yavelov IS, Yakovlev AN, Abugov SA, Alekyan BG, Arkhipov MV, Vasilieva EYu, Galyavich AS, Ganyukov VI, Gilyarevskyi SR, Golubev EP, Golukhova EZ, Gratsiansky NA, Karpov YuA, Kosmacheva ED, Lopatin YuM, Markov VA, Nikulina NN, Pevzner DV, Pogosova NV, Protopopov AV, Skrypnik DV, Tereshchenko SN, Ustyugov SA, Khripun AV, Shalaev SV, Shpektor VA, Yakushin SS. 2020 Clinical practice guidelines for Acute coronary syndrome without ST segment elevation. Russian Journal of Cardiology. 2021;26(4):4449. (In Russ). https://doi.org/10.15829/1560-4071-2021-4449

Lawton JS, Tamis-Holland JE, Bangalore S, Bates ER, Beckie TM, Bischoff JM, Bittl JA, Cohen MG, DiMaio JM, Don CW, Fremes SE, Gaudino MF, Goldberger ZD, Grant MC, Jaswal JB, Kurlansky PA, Mehran R, Metkus TS Jr, Nnacheta LC, Rao SV, Sellke FW, Sharma G, Yong CM, Zwischenberger BA. 2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022;145(3):e4-e17. https://doi.org/10.1161/CIR.0000000000001039

Алекян Б.Г., Бойцов С.А., Маношкина Е.М., Ганюков В.И. Реваскуляризация миокарда в Российской Федерации при остром коронарном синдроме в 2016−2020 гг. Кардиология. 2021;61(12):4-15. https://doi.org/10.18087/cardio.2021.12.n1879

Alekyan BG, Boytsov SA, Manoshkina EM, Ganyukov VI. Myocardial revascularization in Russian Federation for acute coronary syndrome in 2016-2020. Kardiologiia. 2021;61(12):4-15. (In Russ). https://doi.org/10.18087/cardio.2021.12.n1879

Association of Cardiovascular Nursing and Allied Professions (ACNAP); Association for Acute CardioVascular Care (ACVC); European Association of Percutaneous Cardiovascular Interventions (EAPCI); EURObservational Research Programme (EORP); ESC Patient Forum; ESC Working Group on Thrombosis and ESC Committee for Young Cardiovascular Professionals; Batra G, Aktaa S, Wallentin L, Maggioni AP, Ludman P, Erlinge D, Casadei B, Gale CP. Data standards for acute coronary syndrome and percutaneous coronary intervention: the European Unified Registries for Heart Care Evaluation and Randomised Trials (EuroHeart). Eur Heart J. 2022;43(24):2269-2285. https://doi.org/10.1093/eurheartj/ehac133

Барбараш О.Л, Кашталап В.В. Четвертое универсальное определение инфаркта миокарда. Фокус на инфаркт миокарда 2-го типа. Фундаментальная и клиническая медицина. 2018;3(4):73-82.

Barbarash O, Kashtalap V. Fourth universal definition of myocardial infarction. Focus on the type 2 myocardial infarction. Fundamental and Clinical Medicine. 2018;3(4):73-82. (In Russ).

Aakre KM, Saenger AK, Body R, Collinson P, Hammarsten O, Jaffe AS, Kavsak P, Omland T, Ordonez-Lianos J, Apple FS. Analytical Considerations in Deriving 99th Percentile Upper Reference Limits for High-Sensitivity Cardiac Troponin Assays: Educational Recommendations from the IFCC Committee on Clinical Application of Cardiac Bio-Markers. Clin Chem. 2022;68(8):1022-1030. https://doi.org/10.1093/clinchem/hvac092

Jaffe AS, Lindahl B, Giannitsis E, Mueller C, Cullen L, Hammarsten O, Mockel M, Mair J, Krychtiuk KA, Huber K, Mills NL, Thygesen K. ESC Study Group on Cardiac Biomarkers of the Association for Acute CardioVascular Care: A fond farewell at the retirement of CKMB. Eur Heart J. 2021;42(23):2260-2264. https://doi.org/10.1093/eurheartj/ehaa1079

Lindahl B, Baron T, Albertucci M, Prati F. Myocardial infarction with non-obstructive coronary artery disease. EuroIntervention. 2021;17(11):e875-e887. https://doi.org/10.4244/EIJ-D-21-00426. Erratum in: EuroIntervention. 2022;17(17):e1366

Dönmez E, Özcan S, Tuğrul S, Ziyrek M, İnce O, Nar Sagir G, Baran Yavuz M, Gungor B, Okuyan E, Sahin I. Prognostic value of GRACE risk score in patients hospitalized for coronavirus disease 2019. Coron Artery Dis. 2022;33(6):465-472. https://doi.org/10.1097/MCA.0000000000001162

Moledina SM, Kontopantelis E, Wijeysundera HC, Banerjee S, Van Spall HGC, Gale CP, Shah BN, Mohamed MO, Weston C, Shoaib A, Mamas MA. Ethnicity-dependent performance of the Global Registry of Acute Coronary Events risk score for prediction of non-ST-segment elevation myocardial infarction in-hospital mortality: nationwide cohort study. Eur Heart J. 2022;43(24):2289-2299. https://doi.org/10.1093/eurheartj/ehac052

Angiolillo DJ, Galli M, Collet JP, Kastrati A, O'Donoghue ML. Antiplatelet therapy after percutaneous coronary intervention. EuroIntervention. 2022;17(17):e1371-e1396. https://doi.org/10.4244/EIJ-D-21-00904

Велиева Р.М., Печерина Т.Б., Воробьев А.С., Кашталап В.В., Седых Д.Ю. Актуальные вопросы управления рисками ишемических и геморрагических событий на фоне антитромботической терапии у пациентов с острым коронарным синдромом. Рациональная Фармакотерапия в Кардиологии. 2020;16(6):1024-1030. https://doi.org/10.20996/1819-6446-2020-12-10

Velieva RM, Pecherina TB, Vorobiev AS, Kashtalap VV, Sedykh DY. Actual Issues of Ischemic and Hemorrhagic Events Risk Management During Antithrombotic Therapy in Patients with Acute Coronary Syndrome. Rational Pharmacotherapy in Cardiology. 2020;16(6):1024-1030 (In Russ). https://doi.org/10.20996/1819-6446-2020-12-10

Silvain J, Rakowski T, Lattuca B, Liu Z, Bolognese L, Goldstein P, Hamm C, Tanguay JF, Ten Berg J, Widimsky P, Miller D, Portal JJ, Collet JP, Vicaut E, Montalescot G, Dudek D; ACCOAST Investigators. Interval From Initiation of Prasugrel to Coronary Angiography in Patients With Non-ST-Segment Elevation Myocardial Infarction . J Am Coll Cardiol. 2019;73(8):906-914. https://doi.org/10.1016/j.jacc.2018.11.055

Schüpke S, Neumann FJ, Menichelli M, Mayer K, Bernlochner I, Wöhrle J, Richardt G, Liebetrau C, Witzenbichler B, Antoniucci D, Akin I, Bott-Flügel L, Fischer M, Landmesser U, Katus HA, Sibbing D, Seyfarth M, Janisch M, Boncompagni D, Hilz R, Rottbauer W, Okrojek R, Möllmann H, Hochholzer W, Migliorini A, Cassese S, Mollo P, Xhepa E, Kufner S, Strehle A, Leggewie S, Allali A, Ndrepepa G, Schühlen H, Angiolillo DJ, Hamm CW, Hapfelmeier A, Tölg R, Trenk D, Schunkert H, Laugwitz KL, Kastrati A; ISAR-REACT 5 Trial Investigators. Ticagrelor or Prasugrel in Patients with Acute Coronary Syndromes. N Engl J Med. 2019;381(16):1524-1534. https://doi.org/10.1056/NEJMoa1908973

Vicent L, Diaz-Arocutipa C, Tarantini G, Mojoli M, Hernandez AV, Bueno H. Early vs. Delayed Initiation of Treatment With P2Y12 Inhibitors in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials. Front Cardiovasc Med. 2022;9:862452. https://doi.org/10.3389/fcvm.2022.862452

Xu J, Lo S, Mussap CJ, French JK, Rajaratnam R, Kadappu K, Premawardhana U, Nguyen P, Juergens CP, Leung DY. Impact of Ticagrelor Versus Clopidogrel on Coronary Microvascular Function After Non-ST-Segment-Elevation Acute Coronary Syndrome. Circ Cardiovasc Interv. 2022;15(4):e011419. https://doi.org/10.1161/CIRCINTERVENTIONS.121.011419

Turgeon RD, Koshman SL, Dong Y, Graham MM. P2Y12 inhibitor adherence trajectories in patients with acute coronary syndrome undergoing percutaneous coronary intervention: prognostic implications. Eur Heart J. 2022;43(24):2303-2313. https://doi.org/10.1093/eurheartj/ehac116

Tolsma RT, Fokkert MJ, van Dongen DN, Badings EA, van der Sluis A, Slingerland RJ, van 't Riet E, Ottervanger JP, van 't Hof AWJ. Referral decisions based on a pre-hospital HEART score in suspected non-STelevation acute coronary syndrome: final results of the FamouS Triage study. Eur Heart J Acute Cardiovasc Care. 2022;11(2):160-169. https://doi.org/10.1093/ehjacc/zuab10

Lupu L, Taha L, Banai A, Shmueli H, Borohovitz A, Matetzky S, Gabarin M, Shuvy M, Beigel R, Orvin K, Minha S, Shacham Y, Banai S, Glikson M, Asher E. Immediate and early percutaneous coronary intervention in very high-risk and high-risk non-ST segment elevation myocardial infarction patients. Clin Cardiol. 2022;45(4):359-369. https://doi.org/10.1002/clc.23781

Fagel ND, Leuven SGJ, Kikkert WJ, de Leau MM, van Heerebeek L, Riezebos RK. The Effect of the Timing of Invasive Management on Cardiac Function in Patients with NSTE-ACS, Insights from the OPTIMA-2 Randomized Controlled Trial. J Clin Med. 2021;10(16):3636. https://doi.org/10.3390/jcm10163636

Price S, Katz J, Kaufmann CC, Huber K. The year in cardiovascular medicine 2021: acute cardiovascular care and ischaemic heart disease. Eur Heart J. 2022;43(8):800-806. https://doi.org/10.1093/eurheartj/ehab908

Барбараш О.Л., Каретникова В.Н., Кашталап В.В., Зверева Т.Н., Кочергина А.М. Новая коронавирусная болезнь (COVID-19) и сердечно-сосудистые заболевания. Комплексные проблемы сердечно-сосудистых заболеваний. 2020;9(2):17-28. https://doi.org/10.17802/2306-1278-2020-9-2-17-28

Barbarash OL, Karetnikova VN, Kashtalap VV, Zvereva TN, Kochergina AM. New coronavirus disease (COVID-19) and cardiovascular disease. Complex Issues of Cardiovascular Diseases. 2020;9(2):17-28. (In Russ). https://doi.org/10.17802/2306-1278-2020-9-2-17-28

Raman B, Bluemke DA, Lüscher TF, Neubauer S. Long COVID: postacute sequelae of COVID-19 with a cardiovascular focus. Eur Heart J. 2022;43(11):1157-1172. https://doi.org/10.1093/eurheartj/ehac031

Del Prete A, Conway F, Della Rocca DG, Biondi-Zoccai G, De Felice F, Musto C, Picichè M, Martuscelli E, Natale A, Versaci F. COVID-19, Acute Myocardial Injury, and Infarction. Card Electrophysiol Clin. 2022;14(1):29-39. https://doi.org/10.1016/j.ccep.2021.10.004

Azevedo RB, Botelho BG, Hollanda JVG, Ferreira LVL, Junqueira de Andrade LZ, Oei SSML, Mello TS, Muxfeldt ES. Covid-19 and the cardiovascular system: a comprehensive review. J Hum Hypertens. 2021;35(1):4-11. https://doi.org/10.1038/s41371-020-0387-4

Zanza C, Romenskaya T, Manetti AC, Franceschi F, La Russa R, Bertozzi G, Maiese A, Savioli G, Volonnino G, Longhitano Y. Cytokine Storm in COVID-19: Immunopathogenesis and Therapy. Medicina (Kaunas). 2022;58(2):144. https://doi.org/10.3390/medicina58020144

Asakura H, Ogawa H. COVID-19-associated coagulopathy and disseminated intravascular coagulation. Int J Hematol. 2021;113(1):45-57. https://doi.org/10.1007/s12185-020-03029-y

Hadid T, Kafri Z, Al-Katib A. Coagulation and anticoagulation in COVID-19. Blood Rev. 2021;47:100761. https://doi.org/10.1016/j.blre.2020.100761

Hanff TC, Mohareb AM, Giri J, Cohen JB, Chirinos JA. Thrombosis in COVID-19. Am J Hematol. 2020;95(12):1578-1589. https://doi.org/10.1002/ajh.25982

Tang Y, Hu L, Liu Y, Zhou B, Qin X, Ye J, Shen M, Wu Z, Zhang P. Possible mechanisms of cholesterol elevation aggravating COVID-19. Int J Med Sci. 2021;18(15):3533-3543. https://doi.org/10.7150/ijms.62021

Task Force for the management of COVID-19 of the European Society of Cardiology. ESC guidance for the diagnosis and management of cardiovascular disease during the COVID-19 pandemic: part 2-care pathways, treatment, and follow-up. Eur Heart J. 2022;43(11):1059-1103. https://doi.org/10.1093/eurheartj/ehab697

Fanaroff AC, Garcia S, Giri J. Myocardial Infarction During the COVID-19 Pandemic. JAMA. 2021;326(19):1916-1918. https://doi.org/10.1001/jama.2021

Guddeti RR, Yildiz M, Nayak KR, Alraies MC, Davidson L, Henry TD, Garcia S. Impact of COVID-19 on Acute Myocardial Infarction Care. Cardiol Clin. 2022;40(3):345-353. https://doi.org/10.1016/j.ccl.2022.03.004

Doraiswamy S, Abraham A, Mamtani R, Cheema S. Use of Telehealth During the COVID-19 Pandemic: Scoping Review. J Med Internet Res. 2020;22(12):e24087. https://doi.org/10.2196/24087

The authors declare that there are no conflicts of interest present.