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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">fcmedicine</journal-id><journal-title-group><journal-title xml:lang="ru">Фундаментальная и клиническая медицина</journal-title><trans-title-group xml:lang="en"><trans-title>Fundamental and Clinical Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2500-0764</issn><issn pub-type="epub">2542-0941</issn><publisher><publisher-name>КемГМУ</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">fcmedicine-69</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>ЛЕКАРСТВЕННЫЕ РАСТЕНИЯ И БИОЛОГИЧЕСКИ АКТИВНЫЕ ВЕЩЕСТВА ПРОТИВОГРИБКОВОГО ДЕЙСТВИЯ</article-title><trans-title-group xml:lang="en"><trans-title>MEDICINAL PLANTS AND BIOLOGICALLY ACTIVE SUBSTANCES WITH ANTIFUNGAL PROPERTIES</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Марьин</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mar‘In</surname><given-names>ANDREY A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коломиец</surname><given-names>Н. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Kolomiets</surname><given-names>NATALIA E.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Кемеровский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kemerovo State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Сибирский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Siberian State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2017</year></pub-date><volume>2</volume><issue>4</issue><fpage>45</fpage><lpage>55</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Марьин А.А., Коломиец Н.Э., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Марьин А.А., Коломиец Н.Э.</copyright-holder><copyright-holder xml:lang="en">Mar‘In A.A., Kolomiets N.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://fcm.kemsmu.ru/jour/article/view/69">https://fcm.kemsmu.ru/jour/article/view/69</self-uri><abstract><p>Грибковые заболевания относятся к группе инфекционных заболеваний человека, вызываемых болезнетворными грибами, живущими в воздухе, почве, воде, растениях и даже организме человека, и представляют опасность для людей всех возрастных групп. На сегодняшний день терапия грибковых инфекций имеет ряд существенных нерешенных проблем. Во-первых, ассортимент противогрибковых средств на мировом фармацевтическом рынке представлен продуктами синтетического происхождения, имеющими многочисленные противопоказания к применению, индивидуальную непереносимость, тяжелые побочные эффекты, вплоть до системных нарушений. Другая проблема заключается в том, что имеющиеся на рынке препараты имеют низкую эффективность по отношению к грибам, штаммы которых сформировали со временем устойчивость к данным препаратам, как следствие врач и пациент сталкиваются с низкой эффективностью лечения. В связи с этим актуальным является поиск малотоксичных эффективных средств растительного происхождения с комплексным воздействием на организм. Лекарственные растения являются важным, а иногда и единственным источником биологически активных веществ, определяющих ценность видов для медицинской практики. Представленные в данном сообщении результаты экспериментальных исследований in vitro и in vivo ученых разных стран мира доказывают высокую эффективность минимальных концентраций и разведений суммарных комплексов, биологически активных веществ (эфирных масел, сапонинов, флавоноидов и других), индивидуальных веществ и фракций в отношении наиболее часто встречающихся возбудителей грибковых заболеваний (Microsporum canis, Trichophyton rubrum, Trichophyton mentagrophytes) и показывают возможность использования растительных ресурсов планеты для создания эффективных лекарственных препаратов.</p></abstract><trans-abstract xml:lang="en"><p>Fungal diseases, caused by pathogenic fungi from air, soil, water, plants, and even the human body, are dangerous for humans of all age groups. Currently, commercially available antifungal agents mainly include synthetic products having numerous contraindications and severe side effects. Another problem is a widespread resistance of fungi to antifungal agents. Therefore, the search of medicinal plants containing antifungal substances for the development of non-toxic plant drugs is rapidly ongoing. Experimental studies show the high efficiency of even minimum concentrations of biologically active substances (essential oils, saponins, flavonoids etc.) against the most common fungal pathogens (Microsporum canis, Trichophyton rubrum, Trichophyton mentagrophytes). These data indicate the possibility of using medicinal plants to prepare novel efficient antifungal agents.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>грибковые заболевания</kwd><kwd>лекарственные растения</kwd><kwd>биологически активные вещества</kwd><kwd>противогрибковое действие</kwd><kwd>фенольные соединения</kwd><kwd>эфирные масла</kwd><kwd>сапонины</kwd><kwd>лектины</kwd><kwd>алкалоиды</kwd><kwd>fungal diseases</kwd><kwd>medicinal plants</kwd><kwd>biological active substances</kwd><kwd>antifungal activity</kwd><kwd>phenolic compounds</kwd><kwd>essential oils</kwd><kwd>saponins</kwd><kwd>lectins</kwd><kwd>alkaloids</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">WHO traditional medicine strategy 2002-2005. 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