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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">fcmedicine</journal-id><journal-title-group><journal-title xml:lang="ru">Фундаментальная и клиническая медицина</journal-title><trans-title-group xml:lang="en"><trans-title>Fundamental and Clinical Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2500-0764</issn><issn pub-type="epub">2542-0941</issn><publisher><publisher-name>КемГМУ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.23946/2500-0764-2023-8-2-42-52</article-id><article-id custom-type="elpub" pub-id-type="custom">fcmedicine-714</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Менструальная дисфункция у женщин репродуктивного возраста основных этнических групп Восточной Сибири: кросс-секционное исследование</article-title><trans-title-group xml:lang="en"><trans-title>Menstrual dysfunction in women of reproductive age belonging to major ethnic groups in Eastern Siberia: a cross-sectional study</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7662-8529</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лазарева</surname><given-names>Л. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Lazareva</surname><given-names>L. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лазарева Людмила Михайловна, кандидат медицинских наук, научный сотрудник лаборатории гинекологической эндокринологии</p><p>664003, Россия, г. Иркутск, ул. Тимирязева, д. 16</p></bio><bio xml:lang="en"><p>Dr. Lyudmila M. Lazareva, MD, PhD, Research Fellow, Laboratory of Gynecological Endocrinology</p><p>16, Timiryazeva Street, Irkutsk, 664003</p></bio><email xlink:type="simple">lirken_@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3407-9365</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аталян</surname><given-names>A. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Atalyan</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Аталян Алина Валерьевна, кандидат биологических наук, старший научный сотрудник, лаборатории социально значимых проблем репродуктологии</p><p>664003, Россия, г. Иркутск, ул. Тимирязева, д. 16</p></bio><bio xml:lang="en"><p>Dr. Alina V. Atalyan, PhD, Senior Research Fellow, Laboratory of Socially Significant Problems of Reproduction</p><p>16, Timiryazeva Street, Irkutsk, 664003</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4904-3709</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Беленькая</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Belenkaya</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Беленькая Лилия Васильевна, кандидат медицинских наук, старший научный сотрудник лаборатории физиологии и патологии эндокринной системы</p><p>664003, Россия, г. Иркутск, ул. Тимирязева, д. 16</p></bio><bio xml:lang="en"><p>Dr. Lilia V. Belenkaya, MD, PhD, Senior Research Fellow, Laboratory of Endocrine Physiology and Pathology</p><p>16, Timiryazeva Street, Irkutsk, 664003</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8862-5771</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Данусевич</surname><given-names>И. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Danusevich</surname><given-names>I. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Данусевич Ирина Николаевна, доктор медицинских наук, заведующая лабораторией гинекологической эндокринологии</p><p>664003, Россия, г. Иркутск, ул. Тимирязева, д. 16</p></bio><bio xml:lang="en"><p>Dr. Irina N. Danusevich, MD, PhD, Head of the Laboratory of Gynecological Endocrinology</p><p>16, Timiryazeva Street, Irkutsk, 664003</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5747-7315</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Наделяева</surname><given-names>Я. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Nadelyaeva</surname><given-names>Ya. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Наделяева Яна Геннадьевна, кандидат медицинских наук, научный сотрудник лаборатории гинекологической эндокринологии</p><p>664003, Россия, г. Иркутск, ул. Тимирязева, д. 16</p></bio><bio xml:lang="en"><p>Dr. Yana G. Nadelyaeva, MD, PhD, Research Fellow</p><p>16, Timiryazeva Street, Irkutsk, 664003</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7245-9289</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шарифулин</surname><given-names>Э. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Sharifulin</surname><given-names>E. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шарифулин Эльдар Махарамович, кандидат медицинских наук, старший научный сотрудник лаборатории физиологии и патологии эндокринной системы</p><p>664003, Россия, г. Иркутск, ул. Тимирязева, д. 16</p></bio><bio xml:lang="en"><p>Dr. Eldar M. Sharifulin, MD, PhD, Senior Research Fellow, Laboratory of Endocrine Physiology and Pathology</p><p>16, Timiryazeva Street, Irkutsk, 664003</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6847-9810</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Егорова</surname><given-names>И. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Egorova</surname><given-names>I. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Егорова Ирина Юрьевна, аспирант лаборатории гинекологической эндокринологии</p><p>664003, Россия, г. Иркутск, ул. Тимирязева, д. 16</p></bio><bio xml:lang="en"><p>Dr. Irina Yu. Egorova, MD, PhD student, Laboratory of Gynecological Endocrinology</p><p>16, Timiryazeva Street, Irkutsk, 664003</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7604-6246</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бабаева</surname><given-names>Н. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Babaeva</surname><given-names>N. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бабаева Наталия Игоревна, аспирант лаборатории физиологии и патологии эндокринной системы</p><p>664003, Россия, г. Иркутск, ул. Тимирязева, д. 16</p></bio><bio xml:lang="en"><p>Dr. Natalia I. Babaeva, MD, PhD student, Laboratory of Endocrine Physiology and Pathology</p><p>16, Timiryazeva Street, Irkutsk, 664003</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Салимова</surname><given-names>М. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Salimova</surname><given-names>M. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Салимова Мадинабону Долимжон кизи, младший научный сотрудник, лаборатории гинекологической эндокринологии</p><p>664003, Россия, г. Иркутск, ул. Тимирязева, д. 16</p></bio><bio xml:lang="en"><p>Dr. Madinabonu D. Salimova, MD, Junior Research Fellow, Laboratory of Gynecological Endocrinology</p><p>16, Timiryazeva Street, Irkutsk, 664003</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6271-7803</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сутурина</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Suturina</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лариса Викторовна Сутурина, доктор медицинских наук, профессор, руководитель отдела охраны репродуктивного здоровья</p><p>664003, Россия, г. Иркутск, ул. Тимирязева, д. 16</p></bio><bio xml:lang="en"><p>Prof. Larisa V. Suturina, MD, DSc, Professor, Head of the Department of Reproductive Health</p><p>16, Timiryazeva Street, Irkutsk, 664003</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научный центр проблем здоровья семьи и репродукции человека» Министерства науки и высшего образования Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Center for Family Health and Human Reproduction</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>29</day><month>06</month><year>2023</year></pub-date><volume>8</volume><issue>2</issue><fpage>42</fpage><lpage>52</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лазарева Л.М., Аталян A.В., Беленькая Л.В., Данусевич И.Н., Наделяева Я.Г., Шарифулин Э.М., Егорова И.Ю., Бабаева Н.И., Салимова М.Д., Сутурина Л.В., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Лазарева Л.М., Аталян A.В., Беленькая Л.В., Данусевич И.Н., Наделяева Я.Г., Шарифулин Э.М., Егорова И.Ю., Бабаева Н.И., Салимова М.Д., Сутурина Л.В.</copyright-holder><copyright-holder xml:lang="en">Lazareva L.M., Atalyan A.V., Belenkaya L.V., Danusevich I.N., Nadelyaeva Y.G., Sharifulin E.M., Egorova I.Y., Babaeva N.I., Salimova M.D., Suturina L.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://fcm.kemsmu.ru/jour/article/view/714">https://fcm.kemsmu.ru/jour/article/view/714</self-uri><abstract><p>Цель. Установить распространённость и особенности менструальной дисфункции у женщин репродуктивного возраста различных этнических групп, проживающих в Восточной Сибири.Материалы и методы. В период с марта 2016 по май 2021 гг. проведено кросс-секционное (поперечное) исследование с участием женщин 18−44 лет, подлежащих ежегодному профилактическому осмотру по месту работы (неселективная популяционная выборка), проживающих в Иркутской области и Республике Бурятия.Результаты. В исследование включено 1134 женщины репродуктивного возраста: 715 (63,1%) европеоидной; 312 (27,5%) азиатской (монголоидной) и 107 (9,4%) смешанной, европеоидно/азиатской, этнической принадлежности. Средний возраст наступления менархе в популяции составил 13,3±1,4 лет и не отличался у женщин европеоидной, азиатской и смешанной этнических групп. Дебют менструации в возрасте в 11 лет чаще всего имели представительницы смешанной популяции, в 15 лет – азиатки. Хроническое АМК выявлено у 573/1134 (50,5%), а дисменорея – у 280/1134 (24,7%) обследованных женщин, без значимых отличий среди этнических групп, при этом выраженность симптомов дисменореи была значительнее у женщин-европеоидов по сравнению с азиатками.Заключение. В результате исследования установлены распространённость и разнообразие менструальных дисфункций в популяции женщин репродуктивного возраста Восточной Сибири. Установлено, что наиболее частым вариантом менструальной дисфункции является хроническое аномальное маточное кровотечение (АМК). Нами не выявлено существенных различий в распространённости нерегулярных менструальных циклов, олиго/ановуляции, АМК и дисменореи у женщин репродуктивного возраста в зависимости от этнической принадлежности. В то же время клинические проявления дисменореи зависят от этнической принадлежности и максимально выражены у европеоидов. Учитывая высокую распространённость менструальной дисфункции среди женщин репродуктивного возраста и риски отдалённых неблагоприятных последствий, необходимо внедрение в рутинную практику стандартизированных процедур диагностики для повышения эффективности выявления менструальной дисфункции и применения своевременных мер профилактики и лечения.</p></abstract><trans-abstract xml:lang="en"><p>Aim. To determine the prevalence and features of menstrual dysfunction in premenopausal women of various ethnicities inhabitating Eastern Siberia.Materials and Methods. We conducted a cross-sectional study which included women of reproductive age (18-44 years) living in the Irkutsk region and the Republic of Buryatia. Out of 1134 women, 715 (63.1%) were Caucasians, 312 (27.5%) were Asians (Mongoloid), and 107 (9.4%) were of mixed ethnicity. The data have been collected during the annual physical examination carried out between March 2016 to May 2021,Results. The average age of menarche onset was 13.3 ± 1.4 years and did not differ significantly in Caucasians, Asians, and group of mixed ethnicities. The most frequent ages for menarche were 11 and 15 years among women of mixed ethnicity and Asians, respectively. Chronic abnormal uterine bleeding and dysmenorrhea was detected in 573/1134 (50.5%) and in 280/1134 (24.7%) of the examined women, respectively, without significant differences between the ethnicities. However, dysmenorrhea symptoms were more severe in Caucasians as compared to Asian women.Conclusion. The most frequent variant of menstrual dysfunction is chronic abnormal uterine bleeding. There were no significant differences in the prevalence of irregular menstrual cycles, oligo/anovulation, chronic abnormal uterine bleeding, and dysmenorrhea in women of reproductive age belonging to different ethnicities, although clinical manifestations of dysmenorrhea were most pronounced in Caucasians.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>менструальная дисфункция</kwd><kwd>дисменорея</kwd><kwd>аменорея</kwd><kwd>олигоменорея</kwd><kwd>аномальные маточные кровотечения</kwd><kwd>АМК</kwd><kwd>женщины репродуктивного возраста</kwd><kwd>этника</kwd></kwd-group><kwd-group xml:lang="en"><kwd>menstrual disorders</kwd><kwd>dysmenorrhea</kwd><kwd>amenorrhea</kwd><kwd>oligomenorrhea</kwd><kwd>abnormal uterine bleeding</kwd><kwd>premenopausal women</kwd><kwd>ethnicity</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Fraser I.S., Critchley H.O., Broder M., Munro M.G. 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