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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">fcmedicine</journal-id><journal-title-group><journal-title xml:lang="ru">Фундаментальная и клиническая медицина</journal-title><trans-title-group xml:lang="en"><trans-title>Fundamental and Clinical Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2500-0764</issn><issn pub-type="epub">2542-0941</issn><publisher><publisher-name>КемГМУ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.23946/2500-0764-2023-8-4-16-23</article-id><article-id custom-type="elpub" pub-id-type="custom">fcmedicine-794</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Гиперплазия эндометрия и полипы эндометрия: клинико-анамнестическая характеристика женщин</article-title><trans-title-group xml:lang="en"><trans-title>Endometrial hyperplasia and endometrial polyps: clinical and anamnestic characteristics of women</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9481-8812</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кравченко</surname><given-names>Е. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Kravchenko</surname><given-names>E. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кравченко Елена Николаевна - доктор медицинских наук, профессор, профессор кафедры акушерства и гинекологии №1.</p><p>644043, Омск, ул. Ленина, д. 12</p></bio><bio xml:lang="en"><p>Elena N. Kravchenko - MD, DSc, Professor, Professor of the Department of Obstetrics and Gynecology No. 1, Omsk State Medical University.</p><p>12, Lenina Street, Omsk, 644043</p></bio><email xlink:type="simple">kravchenko.en@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лаутеншлегер</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Lautenschleger</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лаутеншлегер Елена Викторовна - акушер-гинеколог высшей квалификационной категории, врач клиники ООО «МЦСМ «Евромед».</p><p>644119, Омск, ул. Лукашевича, д. 21Б</p></bio><bio xml:lang="en"><p>Elena V. Lautenschleger - obstetrician-gynecologist of the highest qualification category, doctor at Multidisciplinary center for modern medicine «Euromed».</p><p>21B, Lukashevicha Street, Omsk, 644119</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Омский государственный медицинский университет» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Omsk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ООО «Многопрофильный центр современной медицины «Евромед»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Multidisciplinary Center for Modern Medicine «Euromed»</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>02</day><month>01</month><year>2024</year></pub-date><volume>8</volume><issue>4</issue><fpage>16</fpage><lpage>23</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кравченко Е.Н., Лаутеншлегер Е.В., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Кравченко Е.Н., Лаутеншлегер Е.В.</copyright-holder><copyright-holder xml:lang="en">Kravchenko E.N., Lautenschleger E.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://fcm.kemsmu.ru/jour/article/view/794">https://fcm.kemsmu.ru/jour/article/view/794</self-uri><abstract><sec><title>Цель</title><p>Цель. Изучить клинико-анамнестические характеристики пациенток с гиперплазией эндометрия (ГЭ) и полипами эндометрия (ПЭ).</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Проведено ретроспективное исследование, в которое включены 267 больных женщин репродуктивного и перименопаузального возраста, обратившихся за гинекологической помощью в ООО «Евромед» в 2022−2023 гг., которым до получения результатов обследования ставился диагноз N92 – обильные, частые и нерегулярные менструации. В зависимости от полученного результата патоморфологического исследования больных поделили на 3 группы: в группу А включены 89 пациенток с ГЭ; в группу Б – 99 женщин с ПЭ; в группу В (контрольную) – 79 пациенток, у которых была исключена патология эндометрия.</p></sec><sec><title>Результаты исследования</title><p>Результаты исследования. Среди всех обратившихся в клинику женщин с обильными менструальными кровотечениями 33,3% имели ГЭ, 37,1% − ПЭ, 29,6% − овуляторную дисфункцию АМК-О. ГЭ без атипии выявлена в 72 (80,9%) наблюдениях группы А, ГЭ с атипией – у 7 (19,1%), в группе Б ПЭ диагностирован в 91 (91,9%) наблюдении, ПЭ с атипией – в 28 (8,1%). В группе В в 22 (27,8%) случаях определен эндометрий в фазе пролиферации, в 57 (72,2%) – эндометрий в фазе неполноценной секреции.</p></sec><sec><title>Заключение</title><p>Заключение. Для женщин с ГЭ характерны: раннее менархе, отсутствие беременностей и родов в течение жизни, связанное с выбором женщины, контрацепцией, эндокринные заболевания, ожирение, синдром поликистозных яичников, опухоли яичников, обильное кровотечение со сгустками во время менструации, менструация более 8 дней, хроническая железодефицитная анемия. Для женщин с полипами эндометрия характерны: артериальная гипертензия, миома матки, аденомиоз, бесплодие, дисменорея, хронический эндометрит, цервициты и вагиниты в анамнезе, из клинических проявлений – межменструальные кровотечения.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To study the clinical and anamnestic characteristics of patients with endometrial hyperplasia (EH) and endometrial polyps (PE).</p></sec><sec><title>Material and Methods</title><p>Material and Methods. a retrospective study was conducted, which included 267 sick women of reproductive and perimenopausal age who sought gynecological care at «Euromed» in 2022-23, who, before receiving the examination results, were diagnosed with N92 - heavy, frequent and irregular menstruation. Depending on the results of the pathomorphological examination, the patients were divided into 3 groups: group A included 89 patients with GE; group B – 99 women with PE; Group B (control) included 79 patients in whom endometrial pathology was excluded.</p></sec><sec><title>Results</title><p>Results. Among all women who came to the clinic with heavy menstrual bleeding, 33.3% had GE, 37.1% had PE, 29.6% had BUN-O ovulatory dysfunction. GE without atypia was detected in 72 (80.9%) cases of group A, GE with atypia – in 7 (19.1%), in group B PE was diagnosed in 91 (91.9%) cases, PE with atypia – in 28 (8.1%).</p></sec><sec><title>In group B, in 22 (27</title><p>In group B, in 22 (27.8%) cases, the endometrium was identified in the proliferation phase, in 57 (72.2%) cases, the endometrium was identified in the phase of incomplete secretion.</p></sec><sec><title>Conclusion</title><p>Conclusion. Women with GE are characterized by early menarche, absence of pregnancies and childbirth during life associated with the woman’s choice, contraception, endocrine diseases, obesity, polycystic ovary syndrome, ovarian tumors, heavy bleeding with clots during menstruation, menstruation for more than 8 days, chronic iron deficiency anemia. Women with endometrial polyps are characterized by arterial hypertension, uterine fibroids, adenomyosis, infertility, dysmenorrhea, chronic endometritis, a history of cervicitis and vaginitis; clinical manifestations include intermenstrual bleeding.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>гиперплазия эндометрия</kwd><kwd>полипы эндометрия</kwd><kwd>овуляторная дисфункция</kwd><kwd>аномальные маточные кровотечения</kwd></kwd-group><kwd-group xml:lang="en"><kwd>endometrial hyperplasia</kwd><kwd>endometrial polyps</kwd><kwd>ovulatory dysfunction</kwd><kwd>abnormal uterine bleeding</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ring K.L., Mills A.M., Modesitt S.C. Endometrial Hyperplasia. Obstet. Gynecol. 2022;140(6):1061-1075. https://doi.org/10.1097/AOG.0000000000004989</mixed-citation><mixed-citation xml:lang="en">Ring KL, Mills AM, Modesitt SC. Endometrial Hyperplasia. Obstet Gynecol.2022;140(6):1061-1075. https://doi.org/10.1097/AOG.00000000000049892</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Kubyshkin A.V., Aliev L.L., Fomochkina I.I., Kovalenko Y.P., Litvinova S.V., Filonenko T.G., Lomakin N.V., Kubyshkin V.A., Karapetian O.V. Endometrial hyperplasia-related inflammation: its role in the development and progression of endometrial hyperplasia. Inflamm. Res. 2016;65(10):785-794. https://doi.org/10.1007/s00011-016-0960-z</mixed-citation><mixed-citation xml:lang="en">Kubyshkin AV, Aliev LL, Fomochkina II, Kovalenko YP, Litvinova SV, Filonenko TG, Lomakin NV, Kubyshkin VA, Karapetian OV. Endometrial hyperplasia-related inflammation: its role in the development and progression of endometrial hyperplasia. Inflamm Res. 2016;65(10):785-794. https://doi.org/10.1007/s00011-016-0960-z</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Nees L.K., Heublein S., Steinmacher S., Juhasz-Böss I., Brucker S., Tempfer C.B., Wallwiener M. Endometrial hyperplasia as a risk factor of endometrial cancer. Arch Gynecol. Obstet. 2022;306(2):407-421. https://doi.org/10.1007/s00404-021-06380-5</mixed-citation><mixed-citation xml:lang="en">Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, Wallwiener M. Endometrial hyperplasia as a risk factor of endometrial cancer. Arch Gynecol Obstet. 2022;306(2):407-421. https://doi.org/10.1007/s00404-021-06380-5</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Hutt S., Tailor A., Ellis P., Michael A., Butler-Manuel S., Chatterjee J. The role of biomarkers in endometrial cancer and hyperplasia: a literature review. Acta Oncol. 2019;58(3):342-352. https://doi.org/10.1080/0284186X.2018.1540886</mixed-citation><mixed-citation xml:lang="en">Hutt S, Tailor A, Ellis P, Michael A, Butler-Manuel S, Chatterjee J. The role of biomarkers in endometrial cancer and hyperplasia: a literature review. Acta Oncol. 2019;58(3):342-352. https://doi.org/10.1080/0284186X.2018.1540886</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Russo M., Newell J.M., Budurlean L., Houser K.R., Sheldon K., Kesterson J., Phaeton R., Hossler C., Rosenberg J., DeGraff D., Shuman L., Broach J.R., Warrick J.I. Mutational profile of endometrial hyperplasia and risk of progression to endometrioid adenocarcinoma. Cancer. 2020;126(12):2775-2783. https://doi.org/10.1002/cncr.32822</mixed-citation><mixed-citation xml:lang="en">Russo M, Newell JM, Budurlean L, Houser KR, Sheldon K, Kesterson J, Phaeton R, Hossler C, Rosenberg J, DeGraff D, Shuman L, Broach JR, Warrick JI. Mutational profile of endometrial hyperplasia and risk of progression to endometrioid adenocarcinoma. Cancer. 2020;126(12):2775-2783. https://doi.org/10.1002/cncr.32822</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Габидуллина Р.И., Смирнова Г.А., Нухбала Ф.Р., Валеева Е.В., Орлова Ю.И., Шакиров А.А. Гиперпластические процессы эндометрия: современная тактика ведения пациенток. Гинекология. 2019;21(6):53-58. https://doi.org/10.26442/20795696.2019.6.190472</mixed-citation><mixed-citation xml:lang="en">Gabidullina RI, Smirnova GA, Nuhbala FR, Valeeva EV, Orlova YuI, Shakirov AA. Hyperplastic processes of the endometrium: modern tactics of patient management. Gynecology. 2019;21(6):53-58. https://doi.org/10.26442/20795696.2019.6.190472</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Chandra V., Kim J.J., Benbrook D.M., Dwivedi A., Rai R. Therapeutic options for management of endometrial hyperplasia. J. Gynecol. Oncol. 2016;27(1):e8. https://doi.org/10.3802/jgo.2016.27.e8</mixed-citation><mixed-citation xml:lang="en">Chandra V, Kim JJ, Benbrook DM, Dwivedi A, Rai R. Therapeutic options for management of endometrial hyperplasia. J Gynecol Oncol. 2016;27(1):e8. https://doi.org/10.3802/jgo.2016.27.e8</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Sanderson P.A., Critchley H.O., Williams A.R., Arends M.J., Saunders P.T. New concepts for an old problem: the diagnosis of endometrial hyperplasia. Hum. Reprod. Update. 2017;23(2):232-254. https://doi.org/10.1093/humupd/dmw042</mixed-citation><mixed-citation xml:lang="en">Sanderson PA, Critchley HO, Williams AR, Arends MJ, Saunders PT. New concepts for an old problem: the diagnosis of endometrial hyperplasia. Hum Reprod Update. 2017;23(2):232-254. https://doi.org/10.1093/humupd/dmw042</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Yang J.H., Chen C.D., Chen S.U., Yang Y.S., Chen M.J. Factors Influencing the Recurrence Potential of Benign Endometrial Polyps after Hysteroscopic Polypectomy. PLoS One. 2015;10(12):e0144857. https://doi.org/10.1371/journal.pone.0144857</mixed-citation><mixed-citation xml:lang="en">Yang JH, Chen CD, Chen SU, Yang YS, Chen MJ. Factors Influencing the Recurrence Potential of Benign Endometrial Polyps after Hysteroscopic Polypectomy. PLoS One. 2015;10(12):e0144857. https://doi.org/10.1371/journal.pone.0144857</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Tanos V., Berry K.E., Seikkula J., Abi Raad E., Stavroulis A., Sleiman Z., Campo R., Gordts S. The management of polyps in female reproductive organs. Int. J. Surg. 2017;43:7-16. https://doi.org/10.1016/j.ijsu.2017.05.012</mixed-citation><mixed-citation xml:lang="en">Tanos V, Berry KE, Seikkula J, Abi Raad E, Stavroulis A, Sleiman Z, Campo R, Gordts S. The management of polyps in female reproductive organs. Int J Surg. 2017;43:7-16. https://doi.org/10.1016/j.ijsu.2017.05.012</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Al Chami A., Saridogan E. Endometrial polyps and subfertility. J. Obstet. Gynaecol. India. 2017;67(1):9-14. https://doi.org/10.1007/s13224-016-0929-4</mixed-citation><mixed-citation xml:lang="en">Al Chami A, Saridogan E. Endometrial polyps and subfertility. J Obstet Gynaecol India. 2017;67(1):9-14. https://doi.org/10.1007/s13224-016-0929-4</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Pereira A.K., Garcia M.T., Pinhiero W., Ejzenberg D., Soares Jr.J.M., Baracat E.C. What is the influence of cyclooxygenase-2 on postmenopausal endometrial polyps? Climacteric. 2015;18(4):498-502. https://doi.org/10.3109/13697137.2014.966240</mixed-citation><mixed-citation xml:lang="en">Pereira AK, Garcia MT, Pinhiero W, Ejzenberg D, Soares Jr JM, Baracat EC. What is the influence of cyclooxygenase-2 on postmenopausal endometrial polyps? Climacteric. 2015;18(4):498-502. https://doi.org/10.3109/13697137.2014.966240</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Indraccolo U., Di Iorio R., Matteo M., Corona G., Greco P., Indraccolo S.R. The pathogenesis of endometrial polyps: a systematic semi-quantitative review. Eur. J. Gynaecol. Oncol. 2013;34(1):5-22.</mixed-citation><mixed-citation xml:lang="en">Indraccolo U, Di Iorio R, Matteo M, Corona G, Greco P, Indraccolo SR. The pathogenesis of endometrial polyps: a systematic semi-quantitative review. Eur J Gynaecol Oncol. 2013;34(1):5-22.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Cicinelli E., Bettocchi S., de Ziegler D., Loizzi V., Cormio G., Marinaccio M., Trojano G., Crupano F.M., Francescato R., Vitagliano A., Resta L. Chronic Endometritis, a Common Disease Hidden Behind Endometrial Polyps in Premenopausal Women: First Evidence From a Case-Control Study. J. Minim. Invasive Gynecol. 2019;26(7):1346-1350. https://doi.org/10.1016/j.jmig.2019.01.012</mixed-citation><mixed-citation xml:lang="en">Cicinelli E, Bettocchi S, de Ziegler D, Loizzi V, Cormio G, Marinaccio M, Trojano G, Crupano FM, Francescato R, Vitagliano A, Resta L. Chronic Endometritis, a Common Disease Hidden Behind Endometrial Polyps in Premenopausal Women: First Evidence From a Case-Control Study. J Minim Invasive Gynecol. 2019;26(7):1346-1350. https://doi.org/10.1016/j.jmig.2019.01.012</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Topcu H.O., Erkaya S., Guzel A.I., Kokanali M.K., Sarikaya E., Muftuoglu K.H., Doganay M. Risk factors for endometrial hyperplasia concomitant endometrial polyps in pre- and post-menopausal women. Asian. Pac. J. Cancer Prev. 2014;15(13):5423-5425. https://doi.org/10.7314/apjcp.2014.15.13.5423</mixed-citation><mixed-citation xml:lang="en">Topcu HO, Erkaya S, Guzel AI, Kokanali MK, Sarikaya E, Muftuoglu KH, Doganay M. Risk factors for endometrial hyperplasia concomitant endometrial polyps in pre- and post-menopausal women. Asian Pac J Cancer Prev. 2014;15(13):5423-5425. https://doi.org/10.7314/apjcp.2014.15.13.5423</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Оразов М.Р., Михалева Л.М., Пойманова О.Ф., Муллина И.А. Механизмы патогенеза эндометриальных полипов у женщин репродуктивного возраста. Обзор литературы. Гинекология. 2022;24(4):246-250. https://doi.org/10.26442/20795696.2022.4.201807</mixed-citation><mixed-citation xml:lang="en">Orazov MR, Mikhaleva LM, Poymanova OF, Mullina IA. Pathogenesis mechanisms of endometrial polyps in women of reproductive age: a literature review. Gynecology. 2022;24(4):246-250. (In Russ). https://doi.org/10.26442/20795696.2022.4.201807</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Clarke M.A., Long B.J., Sherman M.E., Lemens M.A., Podratz K.C., Hopkins M.R., Ahlberg L.J., Mc Guire L.J., Laughlin-Tommaso S.K., Bakkum-Gamez J.N., Wentzensen N. Risk assessment of endometrial cancer and endometrial intraepithelial neoplasia in women with abnormal bleeding and implications for clinical management algorithms. Am. J. Obstet. Gynecol. 2020;223(4):549.e1-549.e13. https://doi.org/10.1016/j.ajog.2020.03.032</mixed-citation><mixed-citation xml:lang="en">Clarke MA, Long BJ, Sherman ME, Lemens MA, Podratz KC, Hopkins MR, Ahlberg LJ, Mc Guire LJ, Laughlin-Tommaso SK, Bakkum-Gamez JN, Wentzensen N. Risk assessment of endometrial cancer and endometrial intraepithelial neoplasia in women with abnormal bleeding and implications for clinical management algorithms. Am J Obstet Gynecol. 2020;223(4):549.e1-549.e13. https://doi.org/10.1016/j.ajog.2020.03.032</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Саламова К.К., Сапрыкина Л.В., Рамазанова А.М., Мильдзихова З.Т., Столярова Е.В. Клинические особенности пациенток с гиперпластическими процессами эндометрия. РМЖ. Мать и дитя. 2021;4(2):124-129. https://doi.org/10.32364/2618-8430-2021-4-2-124-129</mixed-citation><mixed-citation xml:lang="en">Salamova KK, Saprykina LV, Ramazanova AM, Mil'dzihova ZT, Stolyarova EV. Clinical characteristic of women with endometrial hyperplasia. Russian journal of woman and child health rmzh. 2021;4(2):124-129. (In Russ). https://doi.org/10.32364/2618-8430-2021-4-2-124-129</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Hickey M., Balen A. Menstrual disorders in adolescence: investigation and management. Hum. Reprod. Update. 2003;9(5):493-504. https://doi.org/10.1093/humupd/dmg038</mixed-citation><mixed-citation xml:lang="en">Hickey M, Balen A. Menstrual disorders in adolescence: investigation and management. Hum Reprod Update. 2003;9(5):493-504. https://doi.org/10.1093/humupd/dmg038</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Teede H.J., Misso M.L., Costello M.F., Dokras A., Laven J., Moran L., Piltonen T., Norman R.J.; International PCOS Network. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Fertil. Steril. 2018;110(3):364-379. https://doi.org/10.1016/j.fertnstert.2018.05.004</mixed-citation><mixed-citation xml:lang="en">Teede HJ, Misso ML, Costello MF, Dokras A, Laven J, Moran L, Piltonen T, Norman RJ; International PCOS Network. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Fertil Steril. 2018;110(3):364-379. https://doi.org/10.1016/j.fertnstert.2018.05.004</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Munro M.G., Critchley H.O.D., Fraser I.S., Committee F.M.D. The two FIGO systems for normal and abnormal uterine bleeding symptoms and classification of causes of abnormal uterine bleeding in the reproductive years: 2018 revisions. Int. J. Gynecol. Obst. 2018;143(3):393-408. https://doi.org/10.1002/ijgo.12666</mixed-citation><mixed-citation xml:lang="en">Munro MG, Critchley HOD, Fraser IS, Committee FMD. The two FIGO systems for normal and abnormal uterine bleeding symptoms and classification of causes of abnormal uterine bleeding in the reproductive years: 2018 revisions. Int J Gynecol Obstet. 2018;143(3):393-408. https://doi.org/10.1002/ijgo.12666.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
