References

fcmedicine

Фундаментальная и клиническая медицина

Fundamental and Clinical Medicine

2500-07642542-0941

КемГМУ

10.23946/2500-0764-2024-9-1-72-88

fcmedicine-827

Research Article

ОБЗОРНЫЕ СТАТЬИ

REVIEW ARTICLES

Профиль циркулирующих микроРНК у пациентов с псориатическим артритом

Pattern of Circulating Microrna's in Patients with Psoriatic Arthritis

https://orcid.org/0000-0001-8652-1410

Шестерня

П. А.

Shesternya

P. A.

Шестерня Павел Анатольевич, доктор медицинских наук, профессор, заведующий кафедрой пропедевтики внутренних болезней и терапии с курсом ПО, проректор по научной работе

660022, г. Красноярск, ул. Партизана Железняка, д. 1

Prof. Pavel A. Shesternya, MD, DSc, Professor, Head of the Department of Propaedeutics of Internal Diseases and Therapy, Chief Scientific Officer

1, Partizana Zheleznyaka Street, Krasnoyarsk, 660022

https://orcid.org/0000-0002-2840-837X

Шнайдер

Н. А.

Shnayder

N. A.

Шнайдер Наталья Алексеевна, доктор медицинских наук, профессор, главный научный сотрудник, ведущий научный сотрудник Центра коллективного пользования «Молекулярные и клеточные технологии»

192019, г. Санкт-Петербург, ул. Бехтерева, д. 3

660022, Красноярск, Партизана Железняка ул., д. 1

Prof. Natalia A. Shnayder, MD, DSc, Professor, Chief Researcher, Institute of Personalized Psychiatry and Neurology, Leading Researcher, Molecular and Cell Technologies Core Facility

3, Bekhtereva Street, Saint Petersburg, 192019

1, Partizana Zheleznyaka Street, Krasnoyarsk, 660022

https://orcid.org/0000-0002-3097-1073

Филипенко

Д. Е.

Filipenko

D. E.

Филипенко Дарья Евгеньевна, аспирант кафедры пропедевтики внутренних болезней и терапии с курсом ПО

660022, г. Красноярск, ул. Партизана Железняка, д. 1

Dr. Daria E. Filipenko, MD, PhD Student, Department of Propaedeutics of Internal Diseases and Therapy

1, Partizana Zheleznyaka Street, Krasnoyarsk, 660022

darya.filipenko.96@mail.ru

https://orcid.org/0009-0006-9805-9060

Турчик

Е. В.

Turchik

E. V.

Турчик Евгения Владимировна, аспирант кафедры пропедевтики внутренних болезней и терапии с курсом ПО

660022, г. Красноярск, ул. Партизана Железняка, д. 1

Dr. Evgeniia V. Turchik, MD, PhD Student, Department of Dermatovenerology named after Professor V.I. Prokhorenkov

1, Partizana Zheleznyaka Street, Krasnoyarsk, 660022

https://orcid.org/0000-0002-7017-2268

Васильева

А. О.

Vasilieva

А. О.

Васильева Александра Олеговна, ассистент кафедры пропедевтики внутренних болезней и терапии с курсом ПО

660022, г. Красноярск, ул. Партизана Железняка, д. 1

Dr. Аlexandra О. Vasilieva, MD, Assistant Professor, Department of Propaedeutics of Internal Diseases and Therapy

1, Partizana Zheleznyaka Street, Krasnoyarsk, 660022

https://orcid.org/0000-0001-9528-2781

Капустина

Е. В.

Kapustina

E. V.

Капустина Екатерина Владимировна, кандидат медицинских наук, доцент кафедры пропедевтики внутренних болезней и терапии с курсом ПО

660022, г. Красноярск, ул. Партизана Железняка, д. 1

Dr. Ekaterina V. Kapustina, MD, PhD, Associate Professor, Department of Propaedeutics of Internal Diseases and Therapy

1, Partizana Zheleznyaka Street, Krasnoyarsk, 660022

ФГБОУ ВО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Министерства здравоохранения Российской ФедерацииРоссияV.F. Voino-Yasenetsky Krasnoyarsk State Medical UniversityRussian Federation

ФГБОУ ВО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Министерства здравоохранения Российской Федерации ; ФГБУ «Национальный медицинский исследовательский центр психиатрии и неврологии имени В. М. Бехтерева» Министерства здравоохранения Российской ФедерацииРоссияV.F. Voino-Yasenetsky Krasnoyarsk State Medical University ; V.M. Bekhterev National Medical Research Centre for Psychiatry and NeurologyRussian Federation

2024

29032024

917288

2024

Шестерня П.А., Шнайдер Н.А., Филипенко Д.Е., Турчик Е.В., Васильева А.О., Капустина Е.В.

Shesternya P.A., Shnayder N.A., Filipenko D.E., Turchik E.V., Vasilieva А.О., Kapustina E.V.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://fcm.kemsmu.ru/jour/article/view/827

Псориатический артрит (ПсА) является распространенным ревматическим заболеванием с чрезвычайно вариабельным фенотипом. Основными доменами ПсА являются периферический артрит, спондилит, энтезит и дактилит. Изучение новых механизмов развития ПсА может помочь в поиске ключа к разработке инновационных методов диагностики и персонализированных подходов к лечению этого заболевания. В последние годы активно изучается роль некодирующих рибонуклеиновых кислот (РНК), при этом наибольший интерес исследователей и клиницистов сконцентрирован на изучении роли микроРНК.

Цель настоящего обзора состоит в поиске, обобщении и систематизации доклинических и клинических исследований роли циркулирующих микроРНК в развитии ПсА и обновлении знаний о молекулярных биомаркерах этого заболевания. Авторами проведен поиск публикаций в наукоемких базах данных PubMed, Springer, Web of Science, Clinicalkeys, Scopus, OxfordPress, Cochrane, e-Libray с использованием ключевых слов и их комбинаций. Были проанализированы публикации за 2013-2023 гг., включая оригинальные клинические исследования ПсА и псориаза (ПсО). В результате этого описательного обзора показано, что miR-10b-5p, miR-126-3p, miR-151a-5p и miR-130a-3p могут рассматриваться как перспективные молекулярные биомаркеры ПсА и терапевтического ответа. Однако роль других микроРНК требует обсуждения и нуждается в дальнейшем изучении. В будущем можно будет рассматривать ранее изученные циркулирующие микроРНК, обладающие высокой специфичностью и чувствительностью при ПсА в качестве прогностических молекулярных биомаркеров (предикторов) риска развития и тяжести этого заболевания у пациентов с ПсО.

Psoriatic arthritis (PsA) is a common rheumatic disease with an extremely variable phenotype. The main domains of PsA are peripheral arthritis, spondylitis, enthesitis and dactylitis. Studying new mechanisms of PsA development can help in finding the key to the development of innovative diagnostic methods and personalized approaches to the treatment of this disease. In recent years, the role of non-coding ribonucleic acids (RNA) in various diseases has been actively discussed, and the highest interest of researchers and clinicians has been focused on microRNAs. The purpose of this review was to search and systematize pre-clinical and clinical studies on the role of circulating microRNAs in the development of PsA and to update knowledge about molecular biomarkers of this disease. The search was conducted in PubMed, Springer, Web of Science, Clinicalkeys, Scopus, OxfordPress, The Cochrane Library, and eLibrary databases using specific keywords and their combinations. We have analysed the publications for 2013-2023, including clinical studies of PsA and psoriasis (PsO). As a result of this descriptive review, miR-10b-5p, miR-126-3p, miR-151a-5p, and miR-130a-3p can be considered as promising molecular biomarkers of PsA and therapeutic response. However, the role of other miRs is debatable and needs further study. In the future, it will be possible to consider previously studied circulating microRNAs with high specificity and sensitivity in PsA as prognostic molecular biomarkers (predictors) of the risk of developing and severity of this disease in patients with PsO.

молекулярный биомаркергенетические предикторыпсориазпсориатический артритмикроРНК

molecular biomarkersgenetic predictorspsoriasispsoriatic arthritismicroRNA

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The authors declare that there are no conflicts of interest present.