fcmedicineФундаментальная и клиническая медицинаFundamental and Clinical Medicine2500-07642542-0941КемГМУ10.23946/2500-0764-2024-9-3-98-108fcmedicine-905Research ArticleОБЗОРНЫЕ СТАТЬИREVIEW ARTICLESРоль цитокинов и интерферонов при беременностиThe role of cytokines and interferons during pregnancyhttps://orcid.org/0000-0002-5447-4223БелокриницкаяТ. Е.BelokrinitskayaT. Е.

Белокриницкая Татьяна Евгеньевна, доктор медицинских наук, профессор, заведующая кафедрой акушерства и гинекологии педиатрического факультета и факультета дополнительного профессионального образования

672000, Россия, г. Чита, ул. Горького, д. 39а

Prof. Tatiana Е. Belokrinitskaya, MD, DSc, Professor, Head of the Department of Obstetrics & Gynecology, Faculty of Pediatrics

39a, Gor’kogo Street, Chita, 672000

tanbell24@mail.ruhttps://orcid.org/0000-0001-9244-1038ВитковскийЮ. А.VitkovskyYu. A.

Витковский Юрий Антонович, доктор медицинских наук, профессор, врач-иммунолог

672000, г. Чита, ул. Бабушкина, д. 97

Prof. Yury A. Vitkovsky, MD, DSc, Professor, Immunologist

97, Babushkina Street, Chita, 672000

https://orcid.org/0000-0002-7433-6012ФроловаН. И.FrolovaN. I.

Фролова Наталия Ивановна, доктор медицинских наук, доцент кафедры акушерства и гинекологии педиатрического факультета и факультета дополнительного профессионального образования 

672000, г. Чита, ул. Горького, д. 39а

Prof. Natalia I. Frolova, MD, DSc, Associate Professor, Department of Obstetrics and Gynecology, Pediatric Faculty and Faculty of Professional Retraining

39a, Gor’kogo Street, Chita, 672000

ФГБОУ ВО «Читинская государственная медицинская академия» Министерства здравоохранения Российской ФедерацииРоссияChita State Medical AcademyRussian FederationМедицинский центр «Медлюкс»РоссияMedlux Medical CenterRussian Federation2024270920249398108Copyright © Белокриницкая Т.Е., Витковский Ю.А., Фролова Н.И., 20242024Белокриницкая Т.Е., Витковский Ю.А., Фролова Н.И.Belokrinitskaya T.Е., Vitkovsky Y.A., Frolova N.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://fcm.kemsmu.ru/jour/article/view/905

Иммунные клетки, цитокины и интерфероны – ключевые медиаторы, обеспечивающие процесс гестации от имплантации до родов. От скоординированности взаимодействия их сигнальных путей зависит характер коммуникаций между матерью и плодом, физиологическое течение беременности и её успешный исход, в том числе в условиях респираторных вирусных заболеваний у матери. В данном обзоре представлены актуальные сведения о физиологической и патологической роли цитокинов и интерферонов при гестационной перестройке организма матери, при неосложненной и осложненной беременности. Показано, что цитокины и интерфероны являются ключевыми медиаторами, обеспечивающими неосложненное течение процесса гестации благодаря их способности радикально изменять клеточные функции, межклеточное взаимодействие и экспрессию генов. При нарушении регуляции или неадекватной экспрессии цитокины и интерфероны могут действовать как тератогенные факторы, нарушая процессы развития плода и плаценты и приводя к осложнениям беременности и дефектам развития плода.

Immune cells, cytokines, and interferons are key mediators that ensure the gestational process from implantation to childbirth. The coordination of their signaling pathways determines molecular interactions between the mother and the fetus, the physiological course of pregnancy and its outcomes, particularly in the context of maternal respiratory viral infections. Here we analyze current information on physiological and pathological roles of cytokines and interferons during gestation in both uncomplicated and complicated pregnancies. Disrupted cytokine signaling might significantly alter fetal and placental development, leading to pregnancy complications and birth defects.

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The authors declare that there are no conflicts of interest present.