THERAPEUTIC HYPOTHERMIA AS A METHOD FOR PREVENTION OF MULTIPLE ORGAN FAILURE IN CRITICALLY ILL PATIENTS

Aim: To analyze the efficacy of hypothermia in intensive care patients to prevent multiple organ failure (MOF). Materials and Methods: We conducted a prospective, non-randomized study during 2014-2016. Patients (n = 14) with acute coronary syndrome and cardiogenic shock underwent therapeutic hypothermia (THT), with target temperature of 34°C and duration of 52 (38-84) hours. Patients (n = 10) with the same clinical diagnosis but without THT were considered as a control group. We examined: (1) severity of MOF (SOFA score); (2) central hemodynamic parameters; (3) basal metabolic rate (BMR); (4) serum biochemical markers (S100beta protein, intestinal fatty acid-binding protein (i-FABP), surfactant protein A). Results: We detected a significant increase in severity of MOF from the 2 nd day in the control group compared to the patients who underwent THT. In addition, THT group had significantly decreased BMR and markers of organ damage in comparison with the controls. Conclusion: THT can prevent MOF in critically ill patients.

гипотермия, полиорганная недостаточность, профилактика, белок S100 , интестинальный белок, связывающий жирные кислоты, сурфактантный белок А , hypothermia, multiple organ failure, S100 protein, intestinal fatty acid binding protein, surfactant protein A

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