TYPE 2 DIABETES MELLITUS AND DEPRESSION ARE PREDICTORS OF ADVERSE ANNUAL OUTCOME IN PATIENTS WITH MYOCARDIAL INFARCTION
Abstract
Aim: To determine the prevalence of depression in patients with myocardial infarction (MI) and its association with adverse annual outcome in patients with type 2 diabetes mellitus (T2DM). Materials and Methods: We recruited 198 patients and divided them into two equal (99 patients) age-, gender-, and MI severity-matched groups: with and without T2DM. The follow-up duration was one year. Upon one year, we assessed the prevalence of all-cause mortality, myocardial infarction, and repeated admissions due to unstable angina, which all were considered as adverse outcomes. Results: Patients with T2DMhad higher prevalence of depression compared to those without (p = 0.004). Furthermore, we found significant associations of depression with severe MI, low left ventricular ejection fraction, ventricular arrhythmia, and recurrent MI during in-hospital period, particularly in patients with T2DM. Patients with depression, particularly those with T2DM, had significantly higher risk of an adverse outcome. One-year mortality rate in diabetic patients with and without depression was 50% and 18%, respectively. Conclusions: Depression is a significant factor of an adverse outcome, particularly in patients with T2DM.
About the Authors
Н. Nataliay. Ardashova
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
Н. Natalia B. Lebedeva
Kemerovo State Medical University
Russian Federation
Russian Federation
С. Svetlana A. Pomeshkina
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
О. Olga L. Barbarash
Kemerovo State Medical University
Russian Federation
Russian Federation
References
1. Иоселиани Д. Г., Сельцовский А.П. Раннее поэтапное восстановление нарушенного кровоснабжения сердца и улучшение ближайшего и средне-отдалённого прогноза у больных острым инфарктом миокарда (клинико-патофизиологические и фармакологические аспекты). М.; КолорИтСтудио, 2009; 130 с.
2. Kannel WB, McGee DL. Diabetes and cardiovascular risk factors: the Framingham study. Circulation 1979; 59 (1): 8-13.
3. Аверин Е. Е. Чернова С. И. Прогностическая значимость повышения уровней цитокинов и эмоциональных нарушений у больных ишемической болезнью сердца // Фарматека. 2010. №13. С.109-111.
4. Kendler KS, Gardner CO, Fiske A, Gatz M. Major depression and coronary artery disease in the Swedish twin registry: phenotypic, genetic, and environmental sources of comorbidity. Arch. gen. psychiatry. 2009; 66 (8): 857-863.
5. Bener A, Al-Hamaq A, Dafeeah EE. High prevalence of depression, anxiety and stress symptoms among diabetes mellitus patients. The Open Psychiatry Journal 2011; (5): 5-12.
6. Nichols GA, Brown JB. Unadjusted and adjusted prevalence of diagnosed depression in type 2 diabetes. Diabetes care. 2003; 26 (3): 744-749.
7. Гарганеева Н. П. Концепция факторов риска в оценке прогноза сердечно-сосудистых заболеваний у пациентов с тревожными и депрессивными расстройствами // Сибирский вестник психиатрии и наркологии. 2010. №2 (59). С. 63-66.
8. Оганов Р.Г., Погосова Г.В., Колтунов И.Е., Ромасенко Л.В., Деев А.Д., Юферова Ю.М. Депрессивная симптоматика ухудшает прогноз сердечно-сосудистых заболеваний и снижает продолжительность жизни больных артериальной гипертонией и ишемической болезнью сердца // Кардиология. 2011. Т.51, №2. С.59-66.
9. Albus C. Psychological and social factors in coronary artery disease. Ann Med. 2010; 42 (7): 487-494.
10. Black SA, Markides KS, Black SA, Ray LA. Depression predicts increased incidence of adverse health outcomes in older Mexican Americans with type 2 diabetes. Diabetes care. 2003; 26 (10): 2822-2828.
11. Lin EH, Rutter CM, Katon W, Heckbert SR, Ciechanowski P, Oliver MM et al. Depression and advanced complications of diabetes. Diabetes care. 2010; 33 (2): 264-269.
12. McGrady ME, Laffel L, Drotar D, Repaske D, Hood KK. Depressive symptoms and glycemic control in adolescents with type 1 diabetes: mediational role of blood glucose monitoring. Diabetes care. 2009; 32 (5): 804-806.
13. Медведев В.Э., Мартынов С.Е., Зверев К.В. Психосоматические заболевания в кардиологии (типология и клинико-динамические характеристики)// Психиатрия и психофармакотерапия. 2012. Т.14, №4. С. 34-41.
14. Gerstein HC. Dysglycemia and cardiovascular risk in the general population. Circulation. 2009; 119 (6): 773-775.
15. Kokubo Y, Okamura T, Watanabe M, Higashiyama A, Ono Y, Makino H et al. The relationships of oral glucose tolerance test with all-cause mortality and cardiovascular diseases mortality in a prospective urban Japanese population: the Suita Study. Circulation 2009; 120: S398-S399.
16. Pop C, Petriş A, Dorobanţu M, Sinescu C, Craiu E, Maniţiu I et al. Peculiarities of patients with diabetes mellitus and ST elevation acute myocardial infarction in Romania (RO-STEMI 1997-2009). Romanian Journal of Cardiology 2010; 25: 226-234.
17. Беленькова Ю.А., Тавлуева Е.В., Каретникова В.Н., Зыков М.В., Кашталап В.В., Ганюков В.Н. с соавт. Прогноз у пациентов с инфарктом миокарда с подъемом сегмента ST в зависимости от наличия сахарного диабета 2 типа и выбранной тактики ведения острого периода заболевания // Российский кардиологический журнал. 2012. №5. С.17-24.
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For citations:
Nataliay. Ardashova , Natalia B. Lebedeva , Svetlana A. Pomeshkina , Olga L. Barbarash TYPE 2 DIABETES MELLITUS AND DEPRESSION ARE PREDICTORS OF ADVERSE ANNUAL OUTCOME IN PATIENTS WITH MYOCARDIAL INFARCTION. Fundamental and Clinical Medicine. 2016;1(3):58-65. (In Russ.)
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