Development of a computer program for the diagnosis of polycystic ovary syndrome in women of early reproductive age

Aim. To develop the software for the diagnosis of polycystic ovary syndrome in women of early reproductive age.

Material and Methods. We consecutively recruited 200 women of early reproductive age (18-35 years) with or without polycystic ovary syndrome (100 women per group) and performed standard clinical, laboratory, and ultrasound examination. In particular, we evaluated the duration of the menstrual cycle (oligo/ amenorrhea), ovarian reserve, and ultrasound parameters of the uterus and appendages (antiMullerian hormone level, ovarian volume, and antral follicle count). Anti-Mullerian hormone level was measured by means of enzyme-linked immunosorbent assay while ovarian volume and antral follicle count were examined on the 3rd day of the menstrual cycle using a transvaginal ultrasound examination.

Results. We found statistically significant differences in the indicators of ovarian reserve in women of early reproductive age between the patients with and without polycystic ovary syndrome. Employing a logistic regression analysis, we developed a software for the automated diagnosis of polycystic ovary syndrome. Sensitivity and specificity of this software were 70.9% and 75.7%, respectively.

The «Clinical, Laboratory, and Ultrasound Diagnostics of Polycystic Ovary Syndrome (CLOUDPOS)» software was developed and registered by Federal Intellectual Property Service (certificate No. 2019662249, date of registration 09/19/2019).

Conclusion. Our software can be recommended as an accessory tool for the diagnosis of polycystic ovary syndrome.

1. Sosnova Elena A. Polycystic ovary syndrome. Snegirev Archives of Obstetrics and Gynecology. 2016;3(3):116-129 (In Russ.). https://doi.org/10.18821/2313-8726-2016-3-3-116-129

2. Nazarenko TA, Mishieva NG. Besplodie i vozrast: puti resheni-ya problemy. 2nd ed. Мoscow: Medpress-inform Publ; 2014. (In Russ.).

3. De Leo V, Musacchio MC, Cappelli V, Massaro MG, Morgante G, Petraglia F. Genetic, hormonal and metabolic aspects of PCOS: an update. Reprod Biol Endocrinol. 2016;14(1):38. https://doi.org/10.1186/s12958-016-0173-x

4. Dumesic DA, Oberfield SE, Stener-Victorin E, Marshall JS, Le-gro RS. Scientific Statement on the Diagnostic Criteria, Epidemiology, Pathophysiology, and Molecular Genetics of Polycystic Ovary Syndrome. Endocr Rev. 2015;36(5):487-525. https://doi.org/10.1210/er.2015-1018

5. Adamyan LV, Andreeva EN, Gasparyan SA, Gevorkyan MA, Grigoryan OR, Grineva EN, Gustovarova TA, Dedov II, Demidova TYu, Zaydieva YaZ, Karakhalis LYu, Li-zieva LE, Mel'nichenko GA, Sipridonova NE, Suturina LV, Tarasova MA, Uvarova EV, Filippov OS, Khamoshina MS, Cher-nukha GE, Sheremet'eva EV, Yarmolinskaya MV, Soboleva EL, Yarmolinskaya MI. Sindrom polikistoznykh yaichnikov v repro-duktivnom vozraste (sovremennye podkhody k diagnostike i lech-eniyu). Clinical guidelines (treatment protocol). Мoscow: Minis-terstvo zdravookhraneniya RF; 2015. Accessed January 2019 (In Russ.). https://elibrary.ru/item.asp7id = 26714379

6. Bani Mohammad M, Majdi Seghinsara A. Polycystic Ovary Syndrome (PCOS), Diagnostic Criteria and AMH. Endocr Rev. 2017;18(1):17-21. https://doi.org/10.22034/APJCP.2017.18.L17

7. Gogoladze IN, Fedorova AI. Polycystic ovary syndrome in the practice of a teenage gynecologist: the possibility of prevention, the principles of therapy. Gynecology. 2017;19(2):23-27. (In Russ.).

8. Dubrovina SO. Polycystic ovarian syndrome: a modern overview. Gynecology. 2016;18(5):14-17. (In Russ.).

9. Nazarenko EA. Stimulyatsiya funktsii yaichnikov. 4th ed. Мoscow: Medpress-inform Publ; 2013:38-46. (In Russ.).

10. Khashchenko EP, Uvarova EV, Mamedova FSh. Phenotypic features of polycystic ovary syndro in adolescent girls. Reproduktivnoe zdorov'e detey i podrostkov. 2017;1:37-50. (In Russ.).

11. Elgina S, Artymuk N, Beglova A. Indicators of an ovarian reserve in women of early reproductive age with PCOS depending on the phenotype. Hormone Molecular Biology and Clinical Investigation. 2019;39(3):20180081. https://doi.org/10.1515/hmb-ci-2018-008

12. Lizneva D, Suturina L, Walker W, Brakta S, Gavrilova-Jordan L, Azziz R. Criteria, prevalence, and phenotypes of polycystic ovary syndrome. Fertil Steril. 2016;106(1):6-15. https://doi.org/10.1016/j.fertnstert.2016.05.003

13. Conway G, Dewailly D, Diamanti-Kandarakis E, Escobar-Mor-reale HF, Franks S, Gambineri A, Kelestimur F, Macut D, Micic D, Pasquali R, Pfeifer M, Pignatelli D, Pugeat M, Yildiz BO; ESE PCOS Special Interest Group. The polycystic ovary syndrome: a position statement from the European Society of Endocrinology. Eur J Endocrinol. 2014;171(4):1-29. https://doi.org/10.1530/EJE-14-0253

14. Bani Mohammad M, Majdi Seghinsara A. Polycystic Ovary Syndrome (PCOS), Diagnostic Criteria and AMH. Asian Pac J Cancer Prev. 2017;18(1):17-21. https://doi.org/10.22034/AP-JCP.2017.18.1.17

15. Conway G, Dewailly D, Diamanti-Kandarakis E, Escobar-Mor-reale HF, Franks S, Gambineri A, Kelestimur F, Macut D, Micic D, Pasquali R, Pfeifer M, Pignatelli D, Pugeat M, Yildiz BO; ESE PCOS Special Interest Group. The polycystic ovary syndrome: a position statement from the European Society of Endocrinology. Eur J Endocrinol. 2014;171(4):1-29. https://doi.org/10.1530/EJE-14-0253

16. Romualdi D, Di Florio C, Tagliaferri V, De Cicco S, Gagliano D, Immediata V, Lanzone A, Guido M. The Role of Anti-Mullerian Hormone in the Characterization of the Different Polycystic Ovary Syndrome Phenotypes. Reprod Sci. 2016;23(5):655-661. https://doi.org/10.1177/1933719115611751

17. Prilepskaya VN, Ovsyannikova TV. Ginekologicheskaya endokrinologiya. 3nd ed. Мoscow: Medpress-inform Publ; 2015 (In Russ.).

18. Yildiz BO. Polycystic ovary syndrome: is obesity a symptom? Womens Health (Lond). 2013;9:505-507. https://doi.org/10.2217/whe.13.53

19. Legro RS, Arslanian SA, Ehrmann DA, Hoeger KM, Murad MH, Pasquali R, Welt CK. Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2013;98(12):4565-4592. https://doi.org/10.1210/jc.2013-2350

20. Conway G, Dewailly D, Diamanti-Kandarakis E, Escobar-Mor-reale HF, Franks S, Gambineri A, Kelestimur F, Macut D, Micic D, Pasquali R, Pfeifer M, Pignatelli D, Pugeat M, Yildiz BO; ESE PCOS Special Interest Group. The polycystic ovary syndrome: a position statement from the European Society of Endocrinology. Eur J Endocrinol. 2014;171(4):P1-29. https://doi.org/10.1530/EJE-14-0253