Determinants of serum aldosterone in Kemerovo Region
https://doi.org/10.23946/2500-0764-2020-5-3-42-49
Abstract
Aim. To determine the variability of serum aldosterone in patients with stable coronary artery disease in relation to arterial hypertension status, age, and gender.
Materials and Methods. We recruited 176 consecutive patients with stable coronary artery disease and evaluated serum aldosterone by enzyme-linked immunosorbent assay, further comparing its levels with regards to age, gender, and presence of arterial hypertension.
Results. Average serum aldosterone in patients with stable coronary artery disease was similar in Kemerovo Region and those reported in the literature. Age ≥ 60 years, female gender, and the presence of arterial hypertension were among the serum aldosterone determinants
Conclusions. Females ≥ 60 years of age with a medical history of arterial hypertension have increased serum aldosterone.
Supporting agencies: This study was funded by the Foundation for Young Biomedical Researchers (project number 2017_2) and by Russian Foundation on Basic Research (project number 20-04-00823 А).
About the Authors
B. A. Tkhorenko
Research Institute for Complex Issues of Cardiovascular Diseases; Kemerovo State University
Russian Federation
Russian Federation
Mr. Boris A. Tkhorenko, Research Technician, Laboratory for Genomic Medicine, Department of Experimental Medicine; PhD Student, Department of Physiology and Genetics, Institute of Biology, Ecology, and Natural Resources
6, Sosnovy Boulevard, Kemerovo, 650002
6, Krasnaya Street, Kemerovo, 650000
A. V. Tsepokina
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
Ms. Anna V. Tsepokina, Junior Researcher, Laboratory of Genomic Medicine, Department of Experimental Medicine
6, Sosnovy Boulevard, Kemerovo, 650002
M. B. Lavryashina
Kemerovo State Medical University
Russian Federation
Russian Federation
Prof. Maria B. Lavryashina, DSc, Professor, Department of Microbiology, Immunology and Virology
22a, Voroshilova Street, Kemerovo, 650056
A. V. Ponasenko
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
Dr. Anastasia V. Ponasenko, MD, PhD, Head of the Laboratory for Genomic Medicine, Department of Experimental Medicine
6, Sosnovy Boulevard, Kemerovo, 650002
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Review
For citations:
Tkhorenko B.A., Tsepokina A.V., Lavryashina M.B., Ponasenko A.V. Determinants of serum aldosterone in Kemerovo Region. Fundamental and Clinical Medicine. 2020;5(3):42-49. (In Russ.) https://doi.org/10.23946/2500-0764-2020-5-3-42-49
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