Biomarkers of hemodynamic status in patients with moderate and severe COVID-19
https://doi.org/10.23946/2500-0764-2022-7-4-45-50
Abstract
Aim. To assess laboratory markers of hemodynamic status in patients with moderate to severe COVID-19.
Materials and Methods. Here we examined 15 patients with moderate COVID-19 and 16 critically ill COVID-19 patients. The control group consisted of 20 healthy volunteers. The levels of endothelin-1, brain natriuretic peptide (BNP), and N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured by enzyme-linked immunosorbent assay. The amounts of nitrites (NO2) and nitrates (NO3) were measured by a Griess test (an enzymatic conversion of nitrates to nitrites) with a following colorimetric analysis.
Results. Measurements of endothelin-1, nitrites, and nitrates showed high variability. The levels of NT-proBNP were reduced by 65% and 50% in patients with moderate and severe COVID-19, respectively (p < 0.05). In contrast, the levels of BNP were elevated by 472% and 548% in these patient categories (p < 0.05). These results indicated increased left ventricular load and suggested a heart failure.
Conclusion. Progressive increase of BNP and concurrent reduction of NT-proBNP indicate affected hemodynamics in patients with moderate and severe COVID-19.
About the Author
Yu. K. Shapovalov
Chita State Medical Academy
Russian Federation
Russian Federation
Dr. Yuri K. Shapovalov, MD, Assistant Professor, Department of Otorhinolaryngology
39a, Gor’kogo Street, Chita, 672000
References
1. A. Bonaventura A, Vecchié A, Dagna L, Martinod K, Dixon DL, Van Tassell BW, Dentali F, Montecucco F, Massberg S, Levi M, Abbate A. Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19. Nat Rev Immunol. 2021;21(5):319-329. http://doi.org/10.1038/s41577-021-00536-9
2. Ciceri F, Beretta L, Scandroglio AM, Colombo S, Landoni G, Ruggeri A, Peccatori J, D'Angelo A, De Cobelli F, Rovere-Querini P, Tresoldi M, Dagna L, Zangrillo A. Microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome (MicroCLOTS): an atypical acute respiratory distress syndrome working hypothesis. Crit Care Resusc. 2020;22(2):95-97.
3. Li H, Liu L, Zhang D, Xu J, Dai H, Tang N, Su X, Cao B. SARSCoV-2 and viral sepsis: observations and hypotheses. Lancet. 2020;395(10235):1517-1520. http://doi.org/10.1016/S0140-6736(20)30920-X.
4. Petrishchev NN, Khalepo OV, Vavilenkova YuA, Vlasov TD. Covid-19 and vascular disorders (literature review). Regional blood circulation and microcirculation. 2020;19(3):90-98. (In Russ). http://doi.org/10.24884/1682-6655-2020-19-3-90-98
5. Jin Y, Ji W, Yang H, Chen S, Zhang W, Duan G. Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approaches. Signal Transduct Target Ther. 2020;5(1):293. http://doi.org/10.1038/s41392-020-00454-7
6. Nägele MP, Haubner B, Tanner FC, Ruschitzka F, Flammer AJ. Endothelial dysfunction in COVID-19: Current findings and therapeutic implications. Atherosclerosis. 2020;314:58-62. http://doi.org/10.1016/j.atherosclerosis.2020.10.014
7. Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, Laenger F, Vanstapel A, Werlein C, Stark H, Tzankov A, Li WW, Li VW, Mentzer SJ, Jonigk D. Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19. N Engl J Med. 2020;383(2):120-128. http://doi.org/10.1056/NEJMoa2015432
8. Zinellu A, Sotgia S, Carru C, Mangoni AA. B-Type Natriuretic Peptide Concentrations, COVID-19 Severity, and Mortality: A Systematic Review and Meta-Analysis With Meta-Regression. Front Cardiovasc Med. 2021;8:690790. http://doi.org/10.3389/fcvm.2021.690790
9. Fine I, Kuznik BI, Kaminsky AV, Shenkman L, Kustovsjya EM, Maximova OG. New noninvasive index for evaluation of the vascular age of healthy and sick people. J Biomed Opt. 2012;17(8):087002-1. http://doi.org/10.1117/1.JBO.17.8.087002.
10. Cao Z, Jia Y, Zhu B. BNP and NT-proBNP as Diagnostic Biomarkers for Cardiac Dysfunction in Both Clinical and Forensic Medicine. Int J Mol Sci. 2019;20(8):1820. http://doi.org/10.3390/ijms20081820
11. Nakagawa Y, Nishikimi T, Kuwahara K. Atrial and brain natriuretic peptides: Hormones secreted from the heart. Peptides. 2019;111:18-25. http://doi.org/10.1016/j.peptides.2018.05.012.
12. Nabeh OA, Matter LM, Khattab MA, Esraa Menshawey. "The possible implication of endothelin in the pathology of COVID-19-induced pulmonary hypertension". Pulm Pharmacol Ther. 2021 Dec;71:102082. http://doi.org/10.1016/j.pupt.2021.102082
13. Abraham GR, Kuc RE, Althage M, Greasley PJ, Ambery P, Maguire JJ, Wilkinson IB, Hoole SP, Cheriyan J, Davenport AP. Endothelin-1 is increased in the plasma of patients hospitalised with Covid-19. J Mol Cell Cardiol. 2022;167:92-96. http://doi.org/10.1016/j.yjmcc.2022.03.007
14. Mueller C, McDonald K, de Boer RA, Maisel A, Cleland JGF, Kozhuharov N, Coats AJS, Metra M, Mebazaa A, Ruschitzka F, Lainscak M, Filippatos G, Seferovic PM, Meijers WC, Bayes-Genis A, Mueller T, Richards M, Januzzi JL Jr; Heart Failure Association of the European Society of Cardiology. Heart Failure Association of the European Society of Cardiology practical guidance on the use of natriuretic peptide concentrations. Eur J Heart Fail. 2019;21(6):715- 731. http://doi.org/10.1002/ejhf.1494. PMID: 31222929
15. Jin Y, Wei S, Yao L. Diagnostic performance of miR-214, BNP, NTproBNP and soluble ST2 in acute heart failure. Int J Clin Pract. 2021;75(10):e14643. http://doi.org/10.1111/ijcp.14643
16. Zhao X, Li H, Liu C, Ren Y, Sun C. NT Pro-BNP can be used as a risk predictor of clinical atrial fibrillation with or without left atrial enlargement. Clin Cardiol. 2022;45(1):68-74. http://doi.org/10.1002/clc.23760
17. Zaytsev DN, Shapovalov KG, Lukiyanov SA, Muha NV, Ma-Vande VD, Cheptsov FR, Shilina IN, Zobnina ES. First results of the federal register of persons enfected with COVID-19 in Zabaykalsky krai. Transbaikalian medical bulletin. 2020;2:25-32. (In Russ). http://doi.org/10.52485/19986173_2020.
Review
For citations:
Shapovalov Yu.K. Biomarkers of hemodynamic status in patients with moderate and severe COVID-19. Fundamental and Clinical Medicine. 2022;7(4):45-50. (In Russ.) https://doi.org/10.23946/2500-0764-2022-7-4-45-50
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