Histological features of the placenta in women with premature birth
https://doi.org/10.23946/2500-0764-2023-8-2-33-41
Abstract
Aim. To compare placental morphology in patients with preterm birth and with full-term birth without gynecological infections.
Materials and Methods. We performed a retrospective, case-control study which included 150 women with vaginal delivery (50 women with preterm birth and 100 women with full-term birth). Placental tissues were studied by histological examination.
Results. Histological signs of placental immaturity were detected in all patients with preterm birth and were absent in those with full-term birth (p < 0.001). Placental insufficiency was diagnosed in 27 (54%) women with preterm birth and in 35 (35%) women with full-term birth (χ2 = 4.962, p = 0.026). Partial compensation of placental insufficiency was detected in 10 (20%) women with preterm birth and were not observed in patients with full-term birth. Signs of placental infection were registered in 32 (64%) women with preterm birth and 37 (37%) patients with full-term birth (χ2 = 9.783, p = 0.002). Chronic deciduitis was documented in 9 (18%) women with preterm birth and 7 (7%) women with full-term birth (χ2 = 4.233, p = 0.04), chronic histiocytic intervillositis was found in 16 (32%) women with preterm birth and 11 (11%) women with full-term birth (χ2=9.959, p=0.001), chorioamnionitis was diagnosed in 20 (40%) women with preterm birth and 25 (25%) women with full-term birth (χ2 = 3.571, p = 0.059), respectively. Purulent membranitis was detected only in 5 (10%) women with preterm birth.
Conclusion. Patients with preterm vaginal birth without gynecological infections are characterized by a higher prevalence of placental infections (64%) and placental insufficiency (54%) than women with full-term birth.
About the Authors
Ya. A. Parfenova
Kemerovo State Medical University
Russian Federation
Russian Federation
Dr. Yana A. Parfenova, MD, PhD Student, Ushakova Department of Obstetrics and Gynecology
22a, Voroshilova Street, Kemerovo, 650056
D. A. Artymuk
Peoples' Friendship University of Russia
Russian Federation
Russian Federation
Dr. Dmitry A. Artymuk, MD, Clinical Resident, Department of Obstetrics, Gynecology and Perinatology
6, Miklukho-Maklaya Street, Moscow, 117198
T. Yu. Marochko
Kemerovo State Medical University
Russian Federation
Russian Federation
Dr. Tatiana Yu. Marochko, MD, PhD, Associate Professor, Ushakova Department of Obstetrics and Gynecology
6, Miklukho-Maklaya Street, Moscow, 117198
N. V. Artymuk
Kemerovo State Medical University
Russian Federation
Russian Federation
Prof. Natalia V. Artymuk, MD, DSc, Head of the Ushakova Department of Obstetrics and Gynecology
22a, Voroshilova Street, Kemerovo, 650056
K. V. Marochko
Kemerovo State Medical University
Russian Federation
Russian Federation
Dr. Kristina V. Marochko, MD, PhD, Associate Professor, Ushakova Department of Obstetrics and Gynecology
22a, Voroshilova Street, Kemerovo, 650056
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Review
For citations:
Parfenova Ya.A., Artymuk D.A., Marochko T.Yu., Artymuk N.V., Marochko K.V. Histological features of the placenta in women with premature birth. Fundamental and Clinical Medicine. 2023;8(2):33-41. (In Russ.) https://doi.org/10.23946/2500-0764-2023-8-2-33-41
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