SOME IMMUNE INDICATORS IN PATIENTS WITH AIRWAY OBSTRUCTION AND CONCOMITANT INTESTINAL PARASITOSES
Abstract
Aim. To study basic immune indicators in patients with respiratory diseases accompanied by airway obstruction and intestinal parasitoses. Materials and Methods. We recruited 36 patients with airway obstruction and helminthiases, 31 patients with airway obstruction and protozoan infections, 30 patients with airway obstruction and combined parasitism, and 23 patients with airway obstruction without concomitant parasitoses. We measured the number of CD3+, CD4+, CD8+, and CD16+ cells and calculated CD4/CD8 ratio; in addition, we performed spontaneous and stimulated nitroblue tetrazolium (NBT) test and measured serum levels of IgA, IgM, IgG, IgE, circulating immune complexes, and complement components 3 and 4. Results. Mean values of all lymphocyte parameters were significantly lower while the number of NBT-positive neutrophils was significantly higher in patients with parasitoses compared to those without. Among immunoglobulins, IgM values were significantly lower whereas those for IgG and IgE were significantly higher in patients with airway obstruction and parasitic infections as compared to patients with airway obstruction alone. No considerable intergroup differences in circulatory immune complexes and complement components were revealed. Conclusion. Concomitant parasitoses do not cause severe immune disorders in patients with airway obstruction.
About the Authors
GULZAR R. Alieva
Research Institute of Lung Diseases, Azerbaijan Ministry of Health
Russian Federation
Russian Federation
AIGYUN V. Alkhasova
Research Institute of Lung Diseases, Azerbaijan Ministry of Health
Russian Federation
Russian Federation
References
1. Клиническая аллергология и иммунология: руководство для практикующих врачей / под ред. Л.А. Горячкиной, К.П. Кашкина. М.: Миклош, 2009. 432 с.
2. Аллергология и иммунология: национальное руководство / под ред. Р. М. Хаитова, Н.И. Ильиной. М.: ГЭОТАР-Медиа, 2009. 656 с.
3. Wilson MS, Taylor MD, O'Gorman MT, Balic A, Barr TA, Filbey K, et al. Helminth-induced CD19+CD23hi B cells modulate experimental allergic and autoimmune inflammation. Eur J Immunol. 2010; 40(6):1682-1696.
4. Давис Н.А., Исламова Ж.И., Парпиева Н.Н., Белоцерковец В.Г., Осипова С.О. Влияние сопутствующих кишечных паразитозов на некоторые показатели иммунного статуса у больных туберкулезом легких // Туберкулез и болезни легких. 2012. № 2. С. 47-50
5. Cooper PJ. Mucosal immunology of geohelminth infections in humans. Mucosal Immunology. 2009; 2(4): 288-299.
6. Grainger JR, Smith KA, Hewitson JP, McSorley HJ, Harcus Y, Filbey KJ, et al. Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway. J Exp Med. 2010; 207(11): 2331-2341.
7. Carvalho L, Sun J, Kane C, Marshall F, Krawczyk C, Pearce EJ. Review series on helminths, immune modulation and the hygiene hypothesis: mechanisms underlying helminth modulation of dendritic cell function. Immunology. 2009;126(1): 28-34.
8. Mingomataj EC, Xhixha F, Gjata E. Helminth can protect themselves against rejection inhibiting hostile respiratory allergy symptoms. Allergy. 2006; 61(4): 400-406.
9. Coakley G, Buck AH, Maizels RM. Host parasite communications Messages from helminths for the immune system: Parasite communication and cell-cell interactions. Mol Biochem Parasitol. 2016; 208(1): 33-40.
10. Johnston CJ, McSorley HJ, Anderton SM, Wigmore SJ, Maizels RM. Helminths and immunological tolerance. Transplantation. 2014; 97(2): 127-132.
11. Moreau E, Chauvin A. Immunity against helminths: interactions with the host and the intercurrent infections. J Biomed Biotechnol. 2010; 2010:428593.
12. Zaiss MM, Harris NL. Interactions between the intestinal microbiome and helminth parasites. Parasite Immunol. 2016; 38(1): 5-11.
Review
For citations:
Alieva G.R., Alkhasova A.V. SOME IMMUNE INDICATORS IN PATIENTS WITH AIRWAY OBSTRUCTION AND CONCOMITANT INTESTINAL PARASITOSES. Fundamental and Clinical Medicine. 2018;3(1):30-35. (In Russ.)
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