Treatment of Chronic Endometritis with Vague Symptoms in Patients with Endometrial Hyperplasia
https://doi.org/10.23946/2500-0764-2024-9-1-17-24
Abstract
Aim. To develop new therapeutic approaches for chronic endometritis with vague symptoms, which is frequently diagnosed in patients with endometrial hyperplasia.
Materials and Methods. We collected the material from uterine scrapings in patients (age 25-63 years) with endometrial hyperplasia (diagnosed by ultrasound examination) and abnormal uterine bleeding which occurred during hysteroscopic dilation and curettage. Among the exclusion criteria were intraepithelial neoplasia and atypical endometrial hyperplasia, cancer, systemic inflammation, and hormonal therapy. To verify the diagnosis, we employed immunohistochemistry, digital slide scanning, and morphometry.
Results. This study confirmed the value of immunohistochemical diagnosis underlying the pathogenetic therapy of endometrial hyperplasia using non-steroidal anti-inflammatory drugs. Inflammatory markers indicating the distribution and quantitative alterations in cell populations had the highest diagnostic value.
Conclusion. We developed a molecularly oriented algorithm for the treatment of patients with endometrial hyperplasia. This algorithm improves existing preventive, diagnostic and therapeutic approaches using immunohistochemical techniques. Such molecular testing can help in making correct therapeutic decisions.
Supporting agencies: The work was funded by state assignment FZEG-2023-0009 “Study of the heterogeneity of the tumor microenvironment as a factor of its aggressiveness and resistance to therapy”, under an agreement between the Ministry of Education and Science of Russia and the Federal State Autonomous Educational Institution of Higher Education “Crimea Federal University named after V.I. Vernadsky" No. 075-01400-23-00 dated 12/29/22, topic No. 123030700011-4 dated 03/07/2023.
About the Authors
N. I. Volotskaya
V.I. Vernadsky Crimean Federal University
Russian Federation
Russian Federation
Dr. Nadezhda I. Volotskaya, MD, Obstetrician-Gynecologist, Junior Researcher, Central Research Laboratory
5/7, Lenina Boulevard, Simferopol, 295051, Republic of Crimea
E. P. Golubinskaya
V.I. Vernadsky Crimean Federal University
Russian Federation
Russian Federation
Prof. Elena P. Golubinskaya, MD, DSc, Leading Researcher, Central Research Laboratory
5/7, Lenina Boulevard, Simferopol, 295051, Republic of Crimea
E. Yu. Zyablitskaya
V.I. Vernadsky Crimean Federal University
Russian Federation
Russian Federation
Prof. Evgenia Yu. Zyablitskaya, MD, DSc, Leading Researcher, Central Research Laboratory
5/7, Lenina Boulevard, Simferopol, 295051, Republic of Crimea
Р. E. Maksimova
V.I. Vernadsky Crimean Federal University; Pavlov First St. Petersburg State Medical University
Russian Federation
Russian Federation
Dr. Рolina E. Maksimova, MD, Junior Researcher, Central Research Laboratory, Clinical Resident
5/7, Lenina Boulevard, Simferopol, 295051, Republic of Crimea
6/8, Lva Tolstogo Street, St. Petersburg, 197022
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Review
For citations:
Volotskaya N.I., Golubinskaya E.P., Zyablitskaya E.Yu., Maksimova Р.E. Treatment of Chronic Endometritis with Vague Symptoms in Patients with Endometrial Hyperplasia. Fundamental and Clinical Medicine. 2024;9(1):17-24. (In Russ.) https://doi.org/10.23946/2500-0764-2024-9-1-17-24
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