MECHANISM OF INHIBITORY AND STIMULATORY EFFECTS OF SEROTONIN ON DUODENAL CONTRACTIONS
Abstract
Aim. To investigate the effects of serotonin on duodenal motor activity. Materials and Methods. Experiments were performed on Wistar rats (n=83) which received nembutal anesthesia. We further conducted electromyography and measured hydrostatic pressure in the duodenum. Results. Intraarterial administration of 0.05 mg/kg, 0.1 mg/kg, and 0.15 mg/kg serotonin induced inhibitory responses in 29%, 8.3%, and 6.3% of rats, respectively. Other rats, however, showed stimulatory responses or no specific response. Intravenous administration of serotonin did not enhance bowel contractions. Conclusion. Inhibitory responses occurred at low doses of serotonin due to the activation of presynaptic5-hydroxytryptamine (5-HT, serotonin) receptors while stimulatory responses were induced by high doses of serotonin through muscular 5-HT receptors.
Keywords
двенадцатиперстная кишка,
моторика,
регуляция,
серотонин,
duodenum,
motor activity,
regulation,
serotonin
About the Authors
VIKTOR M. Smirnov
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
DMITRIY S. Sveshnikov
Peoples' Friendship University of Russia
Russian Federation
Russian Federation
ANDREY V. Kuchuk
Peoples' Friendship University of Russia
Russian Federation
Russian Federation
TATIANA E. Kuznetsova
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
ELENA D. Ignatova
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
LARISA V. Trubetskaya
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
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Review
For citations:
Smirnov V.M., Sveshnikov D.S., Kuchuk A.V., Kuznetsova T.E., Ignatova E.D., Trubetskaya L.V. MECHANISM OF INHIBITORY AND STIMULATORY EFFECTS OF SEROTONIN ON DUODENAL CONTRACTIONS. Fundamental and Clinical Medicine. 2018;3(2):6-11. (In Russ.)
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