MECHANISM OF EPIDEMIC PROCESS OF INVASIVE CANDIDIASIS IN HOSPITAL FOR HIV-INFECTED PATIENTS
Abstract
Aim. To investigate whether contact route is involved in transmission of healthcare-associated invasive candidiasis in HIV-infected patients. Materials and Methods. We performed a prospective epidemiological study to assess the colonization of HIV-infected patients by C. albicans in the hospital environment in candidiasis-free and candidiasis-affected locations. We examined 921 clinical samples and 227 samples from hospital facilities. In total, we carried out a microbiology and molecular genetic screening of 70 C. albicans strains. Results. We detected a number of risk factors for invasive candidiasis in HIV-infected patients admitted to the hospital facilities: high level of C. albicans colonization (up to 100%), contamination of the hospital environment (47.3 ± 2.06%), augmented colonization of genitourinary system and gut, increased number of patients with massive colonization of ≥ 2 foci (19.1 ± 1.96% - 57.1 ± 10.8%), and circulation of C. albicans strains with high phospholipase activity. C. albicans strains isolated from these patients shared a similar genetic profile indicative of nosocomial infection. The leading factors of transmission were door and bedside handles, bedside tables and patients’ hands. Conclusion. Contact route is implicated in transmission of nosocomial invasive candidiasis in HIV-positive patients.
About the Authors
IRINA P. Charushina
Perm State Medical University
Russian Federation
Russian Federation
IRINA V. Feldblum
Perm State Medical University
Russian Federation
Russian Federation
MARINA V. Kuznetsova
Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
SVETLANA YU. Balandina
Perm State National Research University
Russian Federation
Russian Federation
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Review
For citations:
Charushina I.P., Feldblum I.V., Kuznetsova M.V., Balandina S.Yu. MECHANISM OF EPIDEMIC PROCESS OF INVASIVE CANDIDIASIS IN HOSPITAL FOR HIV-INFECTED PATIENTS. Fundamental and Clinical Medicine. 2018;3(2):51-58. (In Russ.)
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