FATTY ACID COMPOSITION OF PRECANCEROUS CERVICAL LESIONS AND CERVICAL CANCER TISSUES
Abstract
Aim. To determine the fatty acid composition of lipids extracted from precancerous lesions and malignant tumors of the cervix. Materials and Methods. We first isolated segments from precancerous cervical lesions and cervical cancer along with adjacent normal tissues. Extraction of lipids from homogenized tissues was performed employing Folch method. Fatty acid composition was evaluated utilizing gas-liquid chromatography. Results. Both precancerous and malignant cervical lesions demonstrated higher levels of saturated and odd-chain fatty acids while having lower levels of mono- and polyunsaturated fatty acids in comparison with adjacent normal tissues. We also detected an increased amount of nonadecylic/ nonadecanoic acid (C19:0) in cancerous tissues as compared to both precancerous lesions and healthy cervix. Conclusions. Cervical cancer cells are characterized by an impaired lipid metabolism.
About the Authors
ELENA V. Kayukova
Chita State Medical Academy
Russian Federation
Russian Federation
TATIANA E. Belokrinitskaya
Chita State Medical Academy
Russian Federation
Russian Federation
LEONID F. Sholokhov
Research Center for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
PAVEL P. Tereshkov
Chita State Medical Academy
Russian Federation
Russian Federation
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Review
For citations:
Kayukova E.V., Belokrinitskaya T.E., Sholokhov L.F., Tereshkov P.P. FATTY ACID COMPOSITION OF PRECANCEROUS CERVICAL LESIONS AND CERVICAL CANCER TISSUES. Fundamental and Clinical Medicine. 2018;3(3):35-44. (In Russ.)
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