РЕЦЕПТИВНОСТЬ ЭНДОМЕТРИЯ. МАРКЕРЫ ИМПЛАНТАЦИИ
Аннотация
Процесс имплантации весьма уязвим и требует соблюдения ряда условий: высокой степени синхронности между эндометрием и эмбрионом, адекватного гормонального окружения, нормальных анатомических условий и нормального функционирования половых клеток. Принимая во внимание сложность процесса, становится неудивительным факт частых неудач имплантации. С клинической точки зрения эти неудачи становятся все более значимой проблемой. Бесплодие встречается в среднем у каждой шестой пары, и этот процент продолжает расти.
Ключевые слова
Об авторах
М. Абу-Абдаллах
Макгилл университет, Канадский фонд репродуктивной медицины; Ближневосточное общество фертильности
Россия
Россия
Н. В. Артымук
ФГБОУ ВО «Кемеровский государственный медицинский университет» Министерства здравоохранения Российской Федерации
Россия
Россия
М. Н. Сурина
ФГБОУ ВО «Кемеровский государственный медицинский университет» Министерства здравоохранения Российской Федерации
Россия
Россия
Список литературы
1. Navot D, Bergh PA, Williams M, Garrisi GJ, Guzman I, Sandler B, et al. An insight into early reproductive processes through the in vivo model of ovum donation. J Clin Endocrinol Metab. 1991; 72 (2): 408-414. DOI:10.1210/jcem-72-2-408.
2. Wilcox AJ, Braid DD, Wenberg CR. Time of implantation of the conceptus and loss of pregnancy. N Engl J Med. 1999; 340 (23): 1796-1799. DOI:10.1056/NEJM199906103402304.
3. Lessey BA, Killam AP, Metzger DA, Haney AF, Greene GL, McCarty KS Jr. Immunohistichemical analysis of human uterine estrogen and progesterone receptors throughout the menstrual cycle. J Clin Endocrinol Metab. 1988; 67 (22): 334340. DOI: 10.1210/jcem-67-2-334.
4. Garcia E, Bouchard P, De Brux J, Berdah J, Frydman R, Schaison G, et al. Use of immunocytochemistry of progesterone and estrogen receptors for endometrial dating. J Clin Endocrinol Metab. 1988; 67 (1): 80-87. DOI: 10.1210/jcem-67-1-80.
5. Carson DD, Lagow E, Thathiah A, Al-Shami R, Farach-Carson MC, Vernon M, et al. Changes in gene expression during the early to mid-luteal (receptive phase) transition in human endometrium detected by high-density microarray screening. Mol Hum Reprod. 2002; 8 (9): 871-879. DOI: 10.1093/ molehr/8.9.871.
6. Kao LC, Tulac S, Lobo S, Imani B, Yang JP, Germeyer A, et al. Global gene profiling in human endometrium during the window of implantation. Endocrinology. 2002; 143 (6): 21192138. DOI: 10.1210/endo.143.6.8885.
7. Achache H, Revel A. Endometrial receptivity markers, the journey to successful embryo implantation. Hum Reprod Update. 2006; 12 (6): 731-746. DOI: 10.1093/humupd/dml004.
8. Croxatto HB, Ortiz ME, Díaz S, Hess R, Balmaceda J, Croxatto HD, et al. Studies on the duration of egg transport by the human oviduct. II. Ovum location at various intervals following luteinizing hormone peak. Am J Obstet Gynecol. 1978; 132 (6): 629-634. DOI: https://doi.org/10.1016/0002-9378(78)90854-2.
9. Buster JE, Bustillo M, Rodi IA, Cohen SW, Hamilton M, Simon JA, et al. Biologic and morphologic development of donated human ova recovered by nonsurgical uterine lavage. Am J Obstet Gynecol. 1985; 153 (2): 211-217.
10. Enders AC. Implantation (embryology). In: Encyclopedia Hum Biol. 1991; 4: p. 423.
11. Bentin-Ley U, Sjögren A, Nilsson L, Hamberger L, Larsen JF, Horn T, et al. Presence of uterine pinopodes at the embryoendometrial interface during human implantation in vitro. Hum Reprod. 1999; 14 (2): 515-520. DOI: 10.1093/humrep/14.2.515.
12. Campbell S, Swann HR, Seif MW, Kimber SJ, Aplin JD. Cell adhesion molecules on the oocyte and preimplantation human embryo. Hum Reprod. 1995; 10 (6): 1571-1578.
13. Genbacev OD, Prakobphol A, Foulk RA, Krtolica AR, Ilic D, Singer MS, et al. Trophoblast L-selectin-mediated adhesion at the maternal-fetal interface. Science. 2003; 299 (5605): 405408. DOI: 10.1126/science.1079546.
14. Joshi SG. Progestin-regulated proteins of the human endometrium. Semin Reprod Endocrinol. 1983; 1: 221-236. DOI: 10.1055/s-2008-1067957.
15. Bell SC, Drife JO. Secretory proteins of the endometrium - potential markers for endometrial dysfunction. Bailliere’s Clin Obstet Gynaceol. 1989; 3: 271-291.
16. Usadi RS, Murray MJ, Bagnell RC, Fritz MA, Kowalik AI, Meyer WR, et al. Temporal and morphologic characteristics of pinopod expression across the secretory phase of the endometrial cycle in normally cycling women with proven fertility. Fertil Steril 2003; 79 (4): 970-974. DOI: https://doi. org/10.1016/S0015-0282(02)04929-4.
17. Acosta AA, Elberger L, Borghi M, Calamera JC, Chemes H, Doncel GF, et al. Endometrial dating and determination of the window of implantation in healthy fertile women. Fertil Steril. 2000; 73 (4): 788-798. DOI: https://doi.org/10.1016/S00150282(99)00605-6.
18. Bentin-Ley U, Horn T, Sjögren A, Sorensen S, Falck Larsen J, Hamberger L. Ultrastructure of human blastocyst-endometrial interactions in vitro. J Reprod Fertil. 2000; 120 (2): 337-350. doi:10.1530/jrf.0.1200337.
19. Carson DD, Bagchi I, Dey SK, Enders AC, Fazleabas AT, Lessey BA, et al. Embryo implantation. Dev Biol. 2000; 223 (2): 217-237. DOI: 10.1006/dbio.2000.9767.
20. Bronson RA, Fusi FM. Integrins and human reproduction. Mol Hum Reprod. 1996; 2 (3): 153-168.
21. Sueoka K, Shiokawa S, Miyazaki T, Kuji N, Tanaka M, Yoshimura Y. Integrins and reproductive physiology: expression and modulation in fertilization, embryogenesis, and implantation. Fertil Steril. 1997; 67 (5): 799-811. DOI: 00150282/971$17.00.
22. Apparao KB, Murray MJ, Fritz MA, Meyer WR, Chambers AF, Truong PR, et al. Osteopontin and its receptor alphavbeta (3) integrin are coexpressed in the human endometrium during the menstrual cycle but regulated differentially. J Clin Endocrinol Metab. 2001; 86 (10): 4991-5000. DOI: 10.1210/ jcem.86.10.7906.
23. Von Wolff M, Strowitzki T, Becker V, Zepf C, Tabibzadeh S, Thaler CJ. Endometrial osteopontin, a ligand of beta 3-integrin, is maximally expressed around the time of the «implantation window». Fertil Steril. 2001; 76 (4): 775-781. DOI: https://doi. org/10.1016/S0015-0282(01)02015-5.
24. Stewart DR, Erikson MS, Erikson ME, Nakajima ST, Overstreet JW, Lasley BL, et al. The role of relaxin in glycodelin secretion. J Clin Endocrinol Metab. 1997; 82 (3): 839-846. DOI: 10.1210/ jcem.82.3.3839.
25. Fukuda MN, Sato T, Nakayama J, Klier G, Mikami M, Aoki D, et al. Trophinin and tastin, a novel cell adhesion molecule complex with potential involvement in embryo implantation. Genes Dev. 1995; 9 (10): 1199-1210. DOI: 10.1101/ gad.9.10.1199.
26. Albers A, Thie M, Hohn HP, Denker HW. Differential expression and localization of integrins and CD44 in the membrane domains of human uterine epithelial cells during the menstrual cycle. Acta Anat (Basel). 1995; 153 (1): 12-19. DOI: 0001-5180/95/1531-0012$8.00/0.
27. Yaegashi N, Fujita N, Yajima A, Nakamura M, et al. Menstrual cycle dependent expression of CD44 in normal human endometrium. Hum Pathol. 1995; 26 (8): 862-865. doi. org/10.1016/0046-8177(95)90008-X.
28. Saegusa M, Hashimura M, Okayasu I. CD44 expression in normal, hyperplastic, and malignant endometrium. J Pathol. 1998; 184 (3): 297-306. DOI: 10.1002/(SICI)10969896(199803)184:3<297::AID-PATH995>3.0.CO;2-7.
29. MacCalman CD, Furth EE, Omigbodun A, Bronner M, Coutifaris C, Strauss JF. Regulated expression of cadherin-11 in human epithelial cells: a role for cadherin-11 in trophoblast-endometrium interactions? Dev Dyn. 1996; 206 (2): 201-211. DOI:10.1002/ (SICI)1097-0177(199606)206:2<201::AID-AJA9>3.0.CO;2-M.
30. Getsios S, Chen GT, Stephenson MD, Leclerc P, Blaschuk OW, MacCalman CD. Regulated expression of cadherin-6 and cadherin-11 in the glandular epithelial and stromal cells of the human endometrium. Dev Dyn. 1998; 211 (3): 238247. DOI:10.1002/(SICI)10970177(199803)211:3<238::AIDAJA5>3.0.CO;2-I.
31. Wang J, Rout UK, Bagchi IC, Armant DR. Expression of calcitonin receptors in mouse preimplantation embryos and their function in the regulation of blastocyst differentiation by calcitonin. Development. 1998; 125 (21): 4293-4302.
32. Li Q, Wang J, Armant DR, Bagchi MK, Bagchi IC. Calcitonin down-regulates E-cadherin expression in rodent uterine epithelium during implantation. J Biol Chem. 2002; 277 (48): 46447-46455. DOI:10.1074/jbc.M203555200
33. Savouret JF, Rauch M, Redeuilh G, Sar S, Chauchereau A, Woodruff K, et al. Interplay between estrogens, progestins, retinoic acid and AP-1 on a single regulatory site in the progesterone receptor gene. J Biol Chem. 1994; 269 (46): 28955-28962.
34. Lessey BA, Yeh I, Castelbaum AJ, Fritz MA, Ilesanmi AO, Korzeniowski P, et al. Endometrial progesterone receptors and markers of uterine receptivity in the window of implantation. Fertil Steril. 1996; 65 (3): 477-483. doi.10.1016/S00150282(16)58140-0.
35. Gregory CW, Wilson EM, Apparao KB, Lininger RA, Meyer WR, Kowalik A, et al. Steroid receptor coactivator expression throughout the menstrual cycle in normal and abnormal endometrium. J Clin Endocrinol Metab. 2002; 87 (6): 29602966. DOI:10.1210/jcem.87.6.8572.
36. Lessey BA, Palomino WA, Apparao KB, Young SL, Lininger RA. Estrogen receptor-alpha (ER-alpha) and defects in uterine receptivity in women. Reprod Biol Endocrinol. 2006; 4 Suppl 1: S9. DOI:10.1186/1477-7827-4-S1-S9.
37. Grummer R, Traub O, Winterhager E. Gap junction connexin genes cx26 and cx43 are differentially regulated by ovarian steroidhormones in rat endometrium. Endocrinology. 1999; 140 (6): 2509-2516. DOI: 10.1210/endo.140.6.6640
38. Aplin JD, Kimber SI. Trophoblast-uterine interactions at implantation. Reprod Biol Endocrinol. 2004; 2: 48. DOI: 10.1186/1477-7827-2-48.
39. Bergh PA, Navot D. The impact of embryonic development and endometrial maturity on the timing of implantation. Fertil Steril. 1992; 58 (3): 537-542. doi: 10.1016/S00150282(16)55259-5.
40. Navot D, Bergh PA, Williams M. Garrisi GJ, Guzman I, Sandler B, et al. An insight into early reproductive processes through the in vivo model of ovum donation. J Clin Endocrinol Metab. 1991; 72 (2): 408-414. DOI:10.1210/jcem-72-2-408.
41. Winterhager E, Grümmer R, Jahn E, Willecke K, Traub O. Spatial and temporal expression of connexin26 and connexin43 in rat endometrium during trophoblast invasion. Dev Biol. 1993; 157 (2): 399-409. DOI:10.1006/dbio.1993.1144
42. Grummer R, Hewitt SW, Traub O, Korach KS, Winterhager E. Different regulatory pathways of endometrial connexin expression: preimplantation hormonal-mediated pathway versus embryo implantation-initiated pathway. Biol Reprod. 2004; 71 (1): 273-281. DOI:10.1095/biolreprod.103.024067.
43. Nikas G. Pinopodes as markers of endometrial receptivity in clinical practice. Hum Reprod. 1999; 14 Suppl 2: 99-106. doi.10.1093/humrep/14.suppl_2.99.
44. Creus M, Ordi J, Fábregues F, Casamitjana R, Ferrer B, Coll E, et al. alphavbeta3 integrin expression and pinopod formation in normal and out-of-phase endometria of fertile and infertile women. Hum Reprod. 2002; 17 (9): 2279-2286.
45. Kimber SJ, Lindenberg S, Lundblad A. Distribution of some Gal beta 1-3(4)GlcNAc related carbohydrate antigens on the mouse uterine epithelium in relation to the peri-implantational period. J Reprod Immunol. 1988; 12 (4): 297-313. doi:10.1016/01650378(88)90015-0.
46. Cooper DN, Massa SM, Barondes SH. Endogenous muscle lectin inhibits myoblast adhesion to laminin. J Cell Biol. 1991; 115 (5): 1437-1448. DOI: 10.1083/jcb.115.5.1437.
47. Sutherland A. Mechanisms of implantation in the mouse: differentiation and functional importance of trophoblast giant cell behavior. Dev Biol. 2003; 258 (2): 241-251. doi:10.1016/ S0012-1606(03)00130-1.
48. Klaffky E, Williams R, Yao CC, Ziober B, Kramer R, Sutherland A. Trophoblast-specific expression and function of the integrin alpha 7 subunit in the peri-implantation mouse embryo. Dev Biol. 2001; 239 (1): 161-175. DOI:10.1006/dbio.2001.0404.
49. Popovici RM, Krause MS, Germeyer A, Strowitzki T, von Wolff M. Galectin-9: a new endometrial epithelial marker for the mid- and late-secretory and decidual phases in humans. J Clin Endocrinol Metab. 2005; 90 (11): 6170-6176. DOI: 10.1210/jc.2004-2529.
50. Schmits R, Filmus J, Gerwin N, Senaldi G, Kiefer F, Kundig T, et al. CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity. Blood. 1997; 90 (6): 2217-2233. DOI: 0006-4971/97/9006-0019$3.00/0.
51. Julian J, Das SK, Dey SK, Baraniak D, Ta VT, Carson DD. Expression of heparin/heparan sulfate interacting protein/ ribosomal protein l29 during the estrous cycle and early pregnancy in the mouse. Biol Reprod. 2001; 64 (4): 1165-1175. DOI: 10.1095/biolreprod64.4.1165.
52. Heneweer C, Adelmann HG, Kruse LH, Denker HW, Thie M. Human uterine epithelial RL95-2 cells reorganize their cytoplasmic architecture with respect to Rho protein and F-actin in response to trophoblast binding. Cells Tissues Organs. 2003; 175 (1): 1-8. DOI: 10.1159/000073432.
53. Martin KL, Barlow DH, Sargent IL. Heparin-binding epidermal growth factor significantly improves human blastocyst development and hatching in serum-free medium. Hum Reprod. 1998; 13 (6): 1645-1652.
54. Lessey BA. Assessment of endometrial receptivity. Fertil Steril. 2011; 96 (3): 522-529. doi: 10.1016/j. fertnstert.2011.07.1095.
Рецензия
Для цитирования:
Абу-Абдаллах М., Артымук Н.В., Сурина М.Н. РЕЦЕПТИВНОСТЬ ЭНДОМЕТРИЯ. МАРКЕРЫ ИМПЛАНТАЦИИ. Фундаментальная и клиническая медицина. 2018;3(3):71-77.
For citation:
Аbou-Abdallah М., Artymuk N.V., Surina M.N. ENDOMETRIUM RECEPTIVITY. MАRKERS OF IMPLANTATION. Fundamental and Clinical Medicine. 2018;3(3):71-77. (In Russ.)
Просмотров: 344
Послать статью по эл. почте 