Healthcare workers’ compliance with vaccination in condition of high biological risk
https://doi.org/10.23946/2500-0764-2025-10-4-52-65
Abstract
Aim. To evaluate the attitude of medical personnel to vaccinations in conditions of high biological risks associated with the new coronavirus infection in order to develop effective technologies for correcting their adherence to vaccination in other emergency situations of an epidemic nature. Materials and methods. The study was conducted in several stages corresponding to the 8 epidemic outbreaks of COVID-19 in 2020−2023. According to multicenter anonymous online surveys of medical staff, their commitment to vaccine prevention has been studied, taking into account strategies for perceiving and overcoming stress. The total number of respondents is 7,800. The study used a set of epidemiological, sociological and statistical methods. Results. The gradual changes in the attitude towards vaccination of medical personnel at different stages of the COVID-19 pandemic are demonstrated, with a dynamic increase in vaccination adherence. The occupational risk category with a negative attitude towards vaccinations was the average medical staff and employees of non-medical specialties, mostly female, who had up to 10 years of work experience. Among the main motives for negative attitudes towards vaccinations, the most common were concerns about possible side effects after vaccination, especially in the long term, skepticism about new immunobiological drugs, insufficient time elapsed since the start of clinical trials of new vaccines, and a lack of information. A study of the psycho-emotional state of workers showed that destructive perception of stress factors increased the risk of not receiving vaccination by 1.6 times, and destructive stress management programs by 2.6 times. Conclusion. The results obtained expand the understanding of the mechanisms of forming the attitude of medical personnel to vaccinations against new infectious diseases and provide a basis for developing programs to increase their commitment to vaccination in conditions of high biological risks, based on a competence-based approach that includes the formation and development of professional and supra-professional competencies in immunoprophylaxis.
Keywords
About the Authors
T. A. PlatonovaRussian Federation
Tatyana A. Platonova, MD, Dr. Sci. (Medicine), Deputy Director for Educational Activities, Institute of Preventive Medicine, Associate Professor, Department of epidemiology, social hygiene and organization of the state sanitary and epidemiological service; head, epidemiologist, epidemiological Department; Leading Researcher, Ural-Siberian Scientific and Methodological Center for the Prevention of Infections Associated with the Provision
Repina Street, 3, Yekaterinburg, 620028, Russia
Sheinkmana Street, 113, Yekaterinburg, 620144, Russia
Letnyaya Street, 23, Yekaterinburg, 620030, Russia
A. A. Golubkova
Russian Federation
Alla A. Golubkova, Dr. Sci. (Medicine), Professor, leading
researcher, laboratory of healthcare-associated infections; professor, Department of Epidemiology
Novogireevskaya Street, 3А, Moscow, 111123, Russia
Barrikadnaya Street, 2/1 building 1, Moscow, 125993, Russia
M. S. Sklyar
Russian Federation
Mikhail S. Sklyar, MD, Dr. Sci. (Medicine), General Director
Sheinkmana Street, 113, Yekaterinburg, 620144, Russia
References
1. Briko NI, Feldblyum IV. National concept of development of vaccine prophylaxis in Russia. Epidemiology and Vaccinal Prevention. 2024;23(2):114–123 (In Russ). https://doi:10.31631/2073-3046-2024-23-2-114-123
2. Feldblum IV, Polibin RV, Semerikov VV, Voldschmidt NB, Luchinina SV The rational regional schedule of preventive vaccinations. Epidemiology and Vaccinal Prevention. 2024;23(6):4–12 (In Russ). https://doi:10.31631/2073-3046-2024-23-6-4-12
3. Briko NI, Popovich LD, Mindlina AYa, Volkova OI, Kurilovich EO. Comparative Assessment of Preventable Socioeconomic Damage in Different Approaches to the Prevention of Vaccine-Controlled Infections in the Framework of the National Vaccination Schedule. Epidemiology and Vaccinal Prevention. 2020;19(1):4–13. (In Russ). https://doi.org/10.31631/2073-3046-2020-19-1-4-13
4. Briko NI, Kagramanyan IN, Nikiforov VV, Suranova TG, Chernyavskaya OР, Polezhaeva NA. Pandemic COVID-19. Prevention Measures in the Russian Federation. Epidemiology and Vaccinal Prevention. 2020;19(2):4–12. (In Russ). https://doi.org/10.31631/2073-3046-2020-19-2-4-12
5. Kutyrev VV, Popova AYu, Smolensky VYu, Ezhlova EB, Demina YuV, Safronov VA, et al. Epidemiological Features of New Coronavirus Infection (COVID-19). Communication 1: Modes of Implementation of Preventive and Anti-Epidemic Measures. Problems of Particularly Dangerous Infections. 2020;(1):6–13. (In Russ). https://doi.org/10.21055/0370-1069-2020-1-6-13
6. Kutyrev VV, Popova AYu, Smolensky VYu, Ezhlova EB, Demina YuV, Safronov VA, et al. Epidemiological Peculiarities of New Coronavirus Infection (COVID-2019). Communication 2: Peculiarities of epidemic process development in conjunction with performed anti-epidemic measures around the world and in the Russian Federation. Problems of Particularly Dangerous Infections. 2020;(2):6–12. (In Russ). https://doi.org/10.21055/0370-1069-2020-2-6-12
7. Wang Q, Yang L, Jin H, Lin L. Vaccination against COVID-19: A systematic review and meta-analysis of acceptability and its predictors. Prev Med. 2021;150:106694. https://doi.org/10.1016/j.ypmed.2021.106694
8. Al-Amer R, Maneze D, Everett B, Montayre J, Villarosa AR, Dwekat E, et al. COVID-19 vaccination intention in the first year of the pandemic: A systematic review. J Clin Nurs. 2022;31(1-2):62–86. https://doi.org/10.1111/jocn.15951
9. Watanabe A, Iwagami M, Yasuhara J, Takagi H, Kuno T. Protective effect of COVID-19 vaccination against long COVID syndrome: A systematic review and meta-analysis. Vaccine. 2023;41(11):1783–1790. https://doi.org/10.1016/j.vaccine.2023.02.00
10. Nindrea RD, Usman E, Katar Y, Sari NP. Acceptance of COVID-19 vaccination and correlated variables among global populations: A systematic review and meta-analysis. Clin Epidemiol Glob Health. 2021;12:100899. https://doi.org/10.1016/j.cegh.2021.100899
11. Darbandi A, Koupaei M, Kiani P, Ghanavati R, Najafi P, Hosseini J, et al. Acceptance-Hesitancy of COVID-19 Vaccination and Factors Affecting It in Adults: Systematic Review Study. Immun Inflamm Dis. 2024;12(11):e70076. https://doi.org/10.1002/iid3.70076
12. Norhayati MN, Che Yusof R, Azman YM. Systematic Review and Meta-Analysis of COVID-19 Vaccination Acceptance. Front Med (Lausanne). 2022;8:783982. https://doi.org/10.3389/fmed.2021.783982
13. Matveeva ES, Fedorova AM. Vaccination against covid-19: the opinion of medical students. Ural Medical Journal. 2022;21(1):42–47. (In Russ). https://doi.org/10.52420/2071-5943-2022-21-1-42-47
14. Briko NI, Feldblium IV, Alyeva MKh, Mindlina AYa, Maslennikova NP, Namazova-Baranova LS, et al. The concept of risk communications to ensure adherence to vaccination as a necessary component of the strategic development of immunoprophylaxis in Russia. Public Health. 2021;1(1):32-–43. (In Russ). https://doi.org/10.21045/2782-1676-2021-1-1-32-4
15. Platonova TA, Golubkova AA, Koltunova ES, Smirnova SS, Abdulvalieva VV, Kuznezova OA. National Vaccination Shedule: Quality of Performance and Determining Factors. Epidemiology and Vaccinal Prevention. 2019;18(2):97–103. (In Russ). https://doi.org/10.31631/2073-3046-2019-18-2-97-103
16. Plakida AV, Briko NI, Namazova-Baranova LS, Feldblyum IV, Los’ NA, Ivanova ES. Increasing population adherence to vaccination: evaluation and a systematic approach to implementation. Epidemiology and Vaccinal Prevention. 2022;21(3):4–26. (In Russ). https://doi.org/10.31631/2073-3046-2022-21-3-4-26
17. Platonova TA, Golubkova AA, Smirnova SS, Mischenko VA, Sklyar MS, Karbovnichaya EA, et al. COVID-19 epidemic process in the Russian Federation: determinants and manifestations. Infectious Diseases: News, Opinions, Training. 2023;12(3):8–17. (In Russ). https://doi.org/10.33029/2305-3496-2023-12-3-8-17
18. Ababkov VA, Baryshnikova K, Vorontsova-Wenger OV, Gorbunov IA, Kapranova SV, Pologaeva EA, et al. Validation of the Russian version of the questionnaire "Scale of perceived stress-10"Bulletin of St. Petersburg State University. Episode 16: Psychology. Pedagogy. 2016;2:6–15. (In Russ). https://doi.org/10.21638/11701/spbu16.2016.202
19. The PSS-10 scale of perceived stress. [Electronic resource]. Aviable on: https://vizhub.healthdata.org/gbd-results. Accessed: 20.06.2025.
20. Polibin RV, Mindlina AYa, Briko NI, Korshunov VA, Avagyan AS, Butenkova VS. Monitoring of Vaccination Adherence among Healthcare Workers in the Russian Federation. Epidemiology and Vaccinal Prevention. 2025;24(2):74–87. (In Russ). https://doi.org/10.31631/2073-3046-2025-24-2-74-87
21. Hajure M, Tariku M, Bekele F, Abdu Z, Dule A, Mohammedhussein M, et al. Attitude Towards COVID-19 Vaccination Among Healthcare Workers: A Systematic Review. Infect Drug Resist. 2021;14:3883–3897. https://doi.org/10.2147/IDR.S332792
22. Li M, Luo Y, Watson R, Zheng Y, Ren J, Tang J, et al. Healthcare workers' (HCWs) attitudes and related factors towards COVID-19 vaccination: a rapid systematic review. Postgrad Med J. 2023;99(1172):520–528. https://doi.org/10.1136/postgradmedj-2021-140195
23. Bianchi FP, Stefanizzi P, Brescia N, Lattanzio S, Martinelli A, Tafuri S. COVID-19 vaccination hesitancy in Italian healthcare workers: a systematic review and meta-analysis. Expert Rev Vaccines. 2022;21(9):1289–1300. https://doi.org/10.1080/14760584.2022.2093723
24. Tunз AM, Зevirme A. Attitudes of healthcare workers toward the COVID-19 vaccine and related factors: A systematic review. Public Health Nurs. 2024;41(1):10–21. https://doi.org/10.1111/phn.13250
25. Alalawi M, Alsalloum MA, Garwan YM, Abuzeid M, Alalawi H, Eljaaly K, et al. COVID-19 vaccine hesitancy among healthcare workers in Arab Countries: A systematic review and meta-analysis. PLoS One. 2024;19(1):e0296432. https://doi.org/10.1371/journal.pone.0296432
26. Desye B. Prevalence and Determinants of COVID-19 Vaccine Acceptance Among Healthcare Workers: A Systematic Review. Front Public Health. 2022;10:941206. https://doi.org/10.3389/fpubh.2022.941206
27. Cohen C, Pignata S, Bezak E, Tie M, Childs J. Workplace interventions to improve well-being and reduce burnout for nurses, physicians and allied healthcare professionals: a systematic review. BMJ Open. 2023;13(6):e071203. https://doi.org/10.1136/bmjopen-2022-071203
28. Vindegaard N, Benros ME. COVID-19 pandemic and mental health consequences: Systematic review of the current evidence. Brain Behav Immun. 2020;89:531–542. https://doi.org/10.1016/j.bbi.2020.05.048
29. Riedel B, Horen SR, Reynolds A, Hamidian Jahromi A. Mental Health Disorders in Nurses During the COVID-19 Pandemic: Implications and Coping Strategies. Front Public Health. 2021;9:707358. https://doi.org/10.3389/fpubh.2021.707358
30. Saragih ID, Tonapa SI, Saragih IS, Advani S, Batubara SO, Suarilah I, et al. Global prevalence of mental health problems among healthcare workers during the Covid-19 pandemic: A systematic review and metaanalysis. Int J Nurs Stud. 2021;121:104002. https://doi.org/10.1016/j.ijnurstu.2021.104002
31. Danet Danet A. Psychological impact of COVID-19 pandemic in Western frontline healthcare professionals. A systematic review. Med Clin (Engl Ed). 2021;156(9):449–458. https://doi.org/10.1016/j.medcli.2020.11.009
32. Yang JM, Ye H, Long Y, Zhu Q, Huang H, Zhong YB et al. Effects of Web-Based Mindfulness-Based Interventions on Anxiety, Depression, and Stress Among Frontline Health Care Workers During the COVID-19 Pandemic: Systematic Review and Meta-Analysis. J Med Internet Res. 2023;25:e44000. https://doi.org/10.2196/44000
33. Salari N, Khazaie H, Hosseinian-Far A, Khaledi-Paveh B, Kazeminia M, Mohammadi M, et al. The prevalence of stress, anxiety and depression within front-line healthcare workers caring for COVID-19 patients: a systematic review and meta-regression. Hum Resour Health. 2020;18(1):100. https://doi.org/10.1186/s12960-020-00544-1
34. Platonova TA, Smirnova SS, Golubkova AA, Semenov AV. Scheme "Program for increasing the adherence to vaccinations of medical personnel in conditions of high biological risks" : patent for industrial design No. 146418; No. 2024506489 : application 19.11.2024 : published 07.03.2025. (In Russ). https://www.elibrary.ru/download/elibrary_80528036_13825662.PDF Accessed: 20.06.2025.
Review
For citations:
Platonova T.A., Golubkova A.A., Sklyar M.S. Healthcare workers’ compliance with vaccination in condition of high biological risk. Fundamental and Clinical Medicine. 2025;10(4):52-65. (In Russ.) https://doi.org/10.23946/2500-0764-2025-10-4-52-65





























