Features of digestive system malignancies in the Republic of Karakalpakstan (Uzbekistan) and Astrakhan Oblast, Russian Federation, in 2014-2023
https://doi.org/10.23946/2500-0764-2026-11-2-102-113
Abstract
Aim. To characterize the incidence of malignant neoplasms (MN) of the digestive organs in the Republic of Karakalpakstan (Uzbekistan) and Astrakhan Oblast (Russian Federation) in 2014−2023.
Materials and methods. Data from the Ministry of Health of Uzbekistan Form No. 7 for 2014−2023 and annual publications "Malignant Neoplasms in Russia" for 2014-2023 were used.
Results. The average incidence rate of malignant neoplasms (2014–2023) in the Republic of Karakalpakstan was 69,6 per 100000 population, compared to 370,3 per 100000 in Astrakhan Oblast. The incidence of digestive system MN over the study period was 109,3 per 100000 population in Astrakhan Oblast, which is significantly higher than in the Republic of Karakalpakstan (28,5 per 100000). However, the prevalence of digestive system MN was higher in the Republic of Karakalpakstan (41 %) compared to Astrakhan Oblast (29,4 %). In the group of MN at three localizations (esophagus, stomach, liver, and intrahepatic bile ducts), the rates in the Republic of Karakalpakstan were 8,7 per 100000 population (95 % confidence interval [CI]: [7,4–10,1]), which was higher than in Astrakhan Oblast (6,8 per 100000; 95 % CI: [5,4–8,6]) only for esophageal MN (relative risk [RR] = 1,32; 95 % CI: [1,20– 1,46]).
Conclusion. The relative risk of mortality from MN of the digestive system (DS) in Astrakhan Oblast was more than three times higher (RR = 3,14; 95 % CI: [2,99–3,30]) than in the Republic of Karakalpakstan. Across all localizations, the incidence and mortality rates in the Republic of Karakalpakstan were higher in men, with the exception of esophageal MN, where higher values were observed in women.
About the Author
N. K. Dauletnazarov
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Dr. Nauriz K. Dauletnazarov, MD, Postgraduate Student of the Department of Epidemiology and Evidence-Based Medicine
Bolshaya Pirogovskaya Street, 2, building 2, Moscow, 119435
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Review
For citations:
Dauletnazarov N.K. Features of digestive system malignancies in the Republic of Karakalpakstan (Uzbekistan) and Astrakhan Oblast, Russian Federation, in 2014-2023. Fundamental and Clinical Medicine. 2026;11(2):102-113. (In Russ.) https://doi.org/10.23946/2500-0764-2026-11-2-102-113
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