Serum and endometrial organic acid profile in women with missed abortion
https://doi.org/10.23946/2500-0764-2019-4-3-22-26
Abstract
Aim. To determine the role of organic acids in the pathogenesis of missing abortion.
Materials and Methods. To analyze the endometrial organic acid content, we applied high performance liquid chromatography. Sampling was performed from 20 women with missed abortion and 10 patients with normal pregnancy utilising the vacuum aspiration. Following protein separation by means of double centrifugation and ultrafiltration, supernatant was profiled for the organic acids.
Results. Women who experienced missing abortion had significantly higher concentrations of serum and endometrial lactic acid concentrations (10.01 ± 0.16 and 8.28 ± 0.20 mmol/L, respectively) than those with healthy pregnancy (8.16 ± 0.24 and 7.57 ± 0.20 mmol/L, respectively). In contrast, endometrial pyruvic acid level was lower in abortion group (27.71 ± 0.04 mmol/L) as compared to the controls (34.1 ± 0.40 mmol/L). Furthermore, 4-hydroxyphenylacetic acid was found exclusively in women with missed abortion.
Conclusion. Changes in organic acid profile may play a major role in pathogenesis of missed abortion. Serum and endometrial 4-hydroxyphenylacetic acid can be suggested as a novel biomarker of early pregnancy loss.
About the Authors
I. M. Ordiyants
Peoples’ Friendship University of Russia
Russian Federation
Russian Federation
MD, DSc, Professor, Department of Obstetrics, Gynecology, and Maternal-Fetal Medicine,
Moscow
S. S. Barabasheva
Peoples’ Friendship University of Russia
Russian Federation
Russian Federation
MD, PhD Student, Department of Obstetrics, Gynecology, and Maternal-Fetal Medicine,
6, Miklukho-Maklaya Street, Moscow, 117198
A. M. Savicheva
Peoples’ Friendship University of Russia
Russian Federation
Russian Federation
MD, PhD Student, Department of Obstetrics, Gynecology, and Maternal-Fetal Medicine,
Moscow,
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Review
For citations:
Ordiyants I.M., Barabasheva S.S., Savicheva A.M. Serum and endometrial organic acid profile in women with missed abortion. Fundamental and Clinical Medicine. 2019;4(3):22-26. (In Russ.) https://doi.org/10.23946/2500-0764-2019-4-3-22-26
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