Prediction of perinatal complications of gestational diabetes
https://doi.org/10.23946/2500-0764-2019-4-4-19-25
Abstract
Aim. To develop a tool for the prediction of perinatal complications in pregnant women with gestational diabetes utilizing conventional and ultrasound markers of diabetic fetopathy.
Materials and Methods. We analyzed 128 case histories of women who suffered from gestational diabetes. Among their newborns, 35 had clinical manifestations of maternal hyperglycemia (birth weight > 90th percentile, neonatal hyperglycemia, respiratory distress syndrome, and neonatal jaundice) while 74 were free of the indicated signs and symptoms.
Results. Risk factors of maternal hyperglycemia manifestations in neonates included family history of diabetes mellitus type 2, obesity, and pre-eclampsia. Maternal hyperglycemia was significantly associated with the higher risk of adverse perinatal outcomes. A combination of ≥ 4 ultrasound оценке markers of a diabetic fetopathy permitted the diagnosis of the fetal macrosomia. Conclusion. Ultrasound markers of diabetic fetopathy have limited sensitivity in the prediction of perinatal complications after gestational diabetes.
About the Authors
O. V. RozhkovaRussian Federation
Dr. Olga V. Rozhkova, Dr., PhD Student, Department of Obstetrics and Gynecology, Altai State Medical University(40, Lenina Prospekt, Barnaul,656038, Russian Federation); Ultrasound Specialist, Altai Regional Clinical Perinatal Center
40, Lenina Prospekt, Barnaul, 656038
O. V. Remneva
Russian Federation
Olga V. Remneva, Prof., MD, DSc, Professor, Head of the Department of Obstetrics and Gynecology, Altai State Medical University
40, Lenina Prospekt, Barnaul, 656038
N. V. Trukhacheva
Russian Federation
Nina V. Trukhacheva, Dr., PhD, Associate Professor, Department of Physics and Informatics
40, Lenina Prospekt, Barnaul, 656038
References
1. International Association of Diabetes and Pregnancy Study Groups Consensus Panel, MetzgerBE, GabbeSG, PerssonB, BuchananTA, CatalanoPA, DammP, DyerAR, LeivaAd, HodM, KitzmilerJL, LoweLP, McIntyreHD, OatsJJ, OmoriY, SchmidtMI. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care.2010;33(3):676-682. DOI: 10.2337/dc09-1848
2. Sacks DA, Hadden DR, Maresh M, Deerochanawong C, Dyer AR, Metzger BE, Lowe LP, Coustan DR, Hod M, Oats JJ, Persson B, Trimble ER; HAPO Study Cooperative Research Group. Frequency of gestational diabetes mellitus at collaborating centers based on IADPSG consensus panel-recommended criteria: the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study. DiabetesCare. 2012;35(3):526-528. DOI: 10.2337/dc11-1641
3. Dedov II, Krasnopol'skij VI, Suhih GT. Russian National Consensus Statement on gestational diabetes: diagnostics, treatment and postnatal. Sakharnyi diabet.2012;(4):4-10. (In Russ.). DOI: 10.14341/20720351-5531
4. World Health Organization. Diagnostic Criteria and Classification of Hyperglycaemia First Detected in Pregnancy. Ссылка активна на 31.07.2019. https://apps.who.int/iris/bitstream/handle/10665/85975/W?sequence=1.
5. McIntyre HD, Jensen DM, Jensen RC, Kyhl HB, Jensen TK, Glintborg D, Andersen M. Gestational Diabetes Mellitus: Does One Size Fit All? A Challenge to Uniform Worldwide Diagnostic Thresholds. Diabetes Care 2018;41:1337-1338. DOI: 10.2337/dci18-0013
6. Sesmilo G, Meler E, Perea V, Rodríguez I, Rodríguez-Melcón A, Guerrero M, Serra B. Maternal fasting glycemia and adverse pregnancy outcomes in a Mediterranean population. Acta Diabetol. 2017;54(3):293-299. DOI: 10.1007/s00592-0160952-z
Review
For citations:
Rozhkova O.V., Remneva O.V., Trukhacheva N.V. Prediction of perinatal complications of gestational diabetes. Fundamental and Clinical Medicine. 2019;4(4):19-25. (In Russ.) https://doi.org/10.23946/2500-0764-2019-4-4-19-25