The effect of progestagens on immunological risk factors of preterm birth
https://doi.org/10.23946/2500-0764-2019-4-4-26-31
Abstract
Aim. To determine the level of IgA and IgG to estradiol, progesterone, and benzo[a]pyrene in women with or without preterm labor and to assess whether the administration of progestagens affect these parameters.
Materials and Methods. We measured the levels of IgA and IgG to estradiol, progesterone, and benzo[a]pyrene in serum of 199 pregnant women (68 with PL and 81 with normal delivery) with the following analysis of associations between progestagen administration and these parameters.
Results. The level of IgA to estradiol in patients with preterm labor was significantly higher than in women with normal delivery, and the administration of progestagens did not reduce their level in women with preterm birth.
Conclusions. Measurement of the antibodies to estradiol may help in predicting pregnancy complications such as preterm birth.
About the Authors
N. N. Elizarova
Belyaev Kemerovo Regional Hospital
Russian Federation
Russian Federation
Natalia N. Elizarova, Dr., MD, Obstetrician-Gynecologist
22, Oktyabrskiy Prospekt, Kemerovo, 650051
N. V. Artymuk
Kemerovo State Medical University
Russian Federation
Russian Federation
Natalia V. Artymuk, Prof., MD, DSc, Head of the Department of Obstetrics and Gynecology
22a, Voroshilova Street, Kemerovo, 650056
E. G. Polenok
Institute of Human Ecology Siberian Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
Elena G. Polenok, Dr., PhD, Head of the Laboratory for Immunochemistry, Institute of Human Ecology
10, Leningradskiy Prospekt, Kemerovo, 650065
References
1. Yu Y, Gao M, Wang X, Guo Y, Pang Y, Yan H, Hao Y, Zhang Y, Zhang L, Ye R, Wang B, Li Z. Recommended acceptable levels of maternal serum typical toxic metals from the perspective of spontaneous preterm birth in Shanxi Province, China. Sci Total Environ. 2019;686:599-605. DOI 10.1016/j.scitotenv.2019.05.413
2. Stefanovic V, Andersson S, Vento M. Oxidative stress Related spontaneous preterm delivery challenges in causality determination, prevention and novel strategies in reduction of the sequelae. Free Radic Biol Med. 2019;pii: S08915849(18)32495-X. DOI:10.1016/j.freeradbiomed.2019.06.008
3. Yu F., Ye K, Hu Y, Li J, An Y, Qu D. Exposure to polycyclic aromatic hydrocarbons derived from vehicle exhaust gas induces premature senescence in mouse lung fibroblast cells. Mol Med Rep. 2019;19(5):4326-4334. DOI: 10.3892/mmr.2019.10086
4. Wang SW, Ma LL, Huang S, Liang L, Zhang JR. Role of Cervical Cerclage and Vaginal Progesterone in the Treatment of Cervical Incompetence with/without Preterm Birth History. Chin Med J. 2016;29(22):2670-2675. DOI: 0.4103/03666999.193451.
5. Newnham JP, Kemp MW, White SW, Arrese CA, Hart RJ, Keelan JA. Applying Precision Public Health to Prevent Preterm Birth. Front Public Health.2017;5:66. DOI: 10.3389/fpubh.2017.00066
6. Elizarova NN, Artymuk NV, Polenok EG, Kolesnikova NB, Pavlovskaya DV, Grishkevich EV. Limited meanings of antibodies to estradiol, progesterone and benzo[a]pyrene as a risk factor for premature rupture of membranes in women with preterm pregnancy. Mat' i ditya v Kuzbasse. 2016;4(67):23-27. (In Russ.).
7. Uno S, Sakai M, Fujinari Y, Hosono T, Makishima M. Diallyl Trisulfide Enhances Benzo[a]pyrene-induced CYP1A1 Expression and Metabolic Activation in Hepatic HepG2 Cells. Anticancer Res. 2019;39(5):2369-2375. DOI: 10.21873/anticanres.13354
8. Bohîlțea RE, Munteanu O, Turcan N, Baros A, Bodean O, Voicu D, Cîrstoiu MM. A debate about ultrasound and anatomic aspects of the cervix in spontaneouspreterm birth. J Med Life. 2016;9(4):342-347.
9. Kyvernitakis I, Kyvernitakis I, Maul H, Bahlmann F. Controversies about the Secondary Prevention of Spontaneous Preterm Birth. Geburtshilfe Frauenheilkd. 2018;78(6):585595. DOI: 10.1055/a-0611-5337
10. Adamyan, LV, Artymuk NV, Belokrinitskoy TE, Zakharova WA, Ksenofontova OL, Kulikov AV, Leshchenko OY, Martirosyan SV, Oboskalova TA, Olenev AS, Perevozkina OV, Radzinsky VE, Salimova IV, Sevostyanova OY, Simonov HY, Tetruashvili NK, Shifman EM, Filippov OS. Istmikotservikal'naya nedostatochnost'. Problemy reproduktsii. 2018;24(S6):578-602. (In Russ.).
11. Itsekson AM. Intradermal sex hormone desensitization for relief of premenstrual symptoms may improve the obstetric outcome of women with recurrent pregnancy loss. Gynecol Endocrinol. 2013;2:169-172. DOI: 10.3109/09513590.2012.730582.
12. Pokul LV, Matveeva EV. Prediktory tservikal'nykh neoplazii (obzor literatury). Doktor. Ru. 2015;(suppl 2(12)):18-24. (In Russ.).
13. Artymuk NV, Chervov OV, Danilova LN, Polenok EG. The threshold value of antibodies to estrogen and progesterone benzo[a]pyrene as the risk factors for the development of external genital endometriosis. Mat' i Ditya v Kuzbasse. 2019;20 (1):26-30. (In Russ.).
14. Anosova TP, Polenok EG, Anosov MP, Krasil'nikova KS, Kostenko MV, Verzhbitskaya NE, Gurov EA, Vafin IA, Ragozina SE. Antibodies to xeno and endobiotics in patients with breast cancer. Izvestiya Samarskogo nauchnogo tsentra Rossiiskoi akademii nauk. 2012;14(5-2):440-443.
15. Di Renzo, G., Giardina, I., Clerici, G., Brillo E, Gerli S. Progesterone in normal and pathological pregnancy. Horm Mol Biol Clin Investig. 2016;27(1):35-48. DOI:10.1515/hmbci2016-0038
Review
For citations:
Elizarova N.N., Artymuk N.V., Polenok E.G. The effect of progestagens on immunological risk factors of preterm birth. Fundamental and Clinical Medicine. 2019;4(4):26-31. (In Russ.) https://doi.org/10.23946/2500-0764-2019-4-4-26-31
Views:
585
Email this article 