Clinicopathological parallelism in placental microbial colonization
https://doi.org/10.23946/2500-0764-2019-4-4-32-37
Abstract
Aim. To study the course of pregnancy, childbirth and the postpartum period in pregnant women with placental microbial colonization; to investigate placental morphology during the microbial colonization.
Materials and Methods. We retrospectively investigated 128 case histories of the pregnant women with or without (n = 64) placental microbial colonization.
Results. Enterobacteriaceae spp., Enterococcaceae spp. and Staphylococcaceae spp. were respectively isolated from placentas of 24 (37.5%), 19 (29.7%), and 19 (29.7%) women with placental microbial colonization. Candida albicans was isolated in 2 (3.1%) cases. All placentas excised from women without placental microbial colonization were sterile. Vaginal delivery occurred in 61 (95.3%) women with placental microbial colonization but only in 24 (37.5%) women without (p = 0.001). Subinvolution was revealed in 10 (15.6%) and 4 (6.3%) (р = 0.09), lochiometra was found in 4 (6.3%) and 2 (3.1%) (р = 0.409), and wound infections were observed in 5 (7.8%) and 1 (1.6%) (p = 0.095) women with or without placental microbial colonization, respectively. Therefore, prevalence of postpartum complications did not differ significantly between the groups. Placental inflammation was detected in 27(42.2%) and 14 (21.9%) (p = 0.014) patients with or without placental microbial colonization, respectively.
Conclusions. Placental inflammation is associated with microbial colonization which is more common in women who undergo vaginal delivery.
About the Authors
T. Yu. Marochko
Kemerovo State Medical University
Russian Federation
Russian Federation
Tatyana U. Marochko, Dr., MD, PhD, Associate Professor, Department of Obstetrics and Gynecology
22a, Voroshilova Street, Kemerovo, 650056
L. A. Levanova
Kemerovo State Medical University
Russian Federation
Russian Federation
Lyudmila A. Levanova, Prof., MD, DSc, Professor, Head of the Department of Microbiology, Immunology and Virology
22a, Voroshilova Street, Kemerovo, 650056
N. B. Kolesnikova
Kemerovo State Medical University
Russian Federation
Russian Federation
Natalia B. Kolesnikova, Dr., MD, PhD, Associate Professor, Department of Obstetrics and Gynecology
22a, Voroshilova Street, Kemerovo, 650056
M. N. Surina
Kemerovo State Medical University
Russian Federation
Russian Federation
Maria N. Surina, Dr., MD, PhD, Associate Professor, Department of Obstetrics and Gynecology
22a, Voroshilova Street, Kemerovo, 650056
O. B. Karelina
Kemerovo State Medical University
Russian Federation
Russian Federation
Olga B. Karelina, Dr., MD, PhD, Associate Professor, Department of Obstetrics and Gynecology
22a, Voroshilova Street, Kemerovo, 650056
K. R. Kopytova
Kemerovo State Medical University
Russian Federation
Russian Federation
Kamila R. Kopytova, Dr., MD, Resident, Department of Obstetrics and Gynecology
22a, Voroshilova Street, Kemerovo, 650056
References
1. Albright CM, Mehta ND, Rouse DJ, Hughes BL. Sepsis in Рregnancy: Identification and Management. J Perinat Neonat Nurs. 2016; 30(2):95-105. DOI: 10.1097/JPN.0000000000000159
2. Al-Ostad G, Kezouh A, Spence AR, Abenhaim HA Incidence of and Risk Factors for Sepsis Mortality in Labor, Delivery, and after birth: population-based study in the USA. J Obstet Gynaecol Res. 2015; 41(8):1201-1206. DOI: 10.1111/jog.12710
3. Adamyan LV, Artymuk NV, Belokrinitskaya TE, Gelfand BR, Kulikov AV, Kan NE, Protsenko DN, Pyregov AV, Serov VN, Tyutyunnik VL, Filippov OS, Shifman EM. Septic complications in obstetrics. Problemy reproduktsii. 2018;24(56):358-391. (In Russ.).
4. Adamyan LV., Filippov OS., Artymuk NV. Belokrinitskaya TE., Brusina EB., Grigoriev EV, Zelenina EM, Evtushenko ID, Novikova ON. Purulent inflammatory diseases and sepsis in obstetrics. Problemy reproduktsii. 2018;24(56):191-215. (In Russ.).
5. Svetlichnaya YS., Kolosovskaya EN., Kaftyreva LA., Darina MG., Egorova SA., Makarova MA. Microbiological monitoring in the system of epidemiological surveillance of hospital infections. Epidemiologiya i vaktsinoprofilaktika. 2014;1(74):9-14. (In Russ.).
6. Feldblyum IV, Zakharov YuA, Demenko GS. Scientific bases of bacteriological examination of an afterbirth in the system of microbiological monitoring for the prognosis of the development of purulent-septic infections of parturient women at the early afterbirth period. Meditsinskii al'manakh. 2013;2(26):5356. (In Russ.).
7. Agarev AE., Scolnik TD, Kovalenko MS, Zotov VV. Forecasting development of the infections connected with rendering medical care in postpartum women. Rossiiskii mediko-biologicheskii vestnik im. akad. I.P. Pavlova. 2017;25(4):565-574. (In Russ.). DOI: https://doi.org/10.23888/PAVLOVJ20174565-574
Review
For citations:
Marochko T.Yu., Levanova L.A., Kolesnikova N.B., Surina M.N., Karelina O.B., Kopytova K.R. Clinicopathological parallelism in placental microbial colonization. Fundamental and Clinical Medicine. 2019;4(4):32-37. (In Russ.) https://doi.org/10.23946/2500-0764-2019-4-4-32-37
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