Levels of thyroid-stimulating and thyroid hormones in pregnant women with obesity and their newborns
https://doi.org/10.23946/2500-0764-2019-4-4-58-63
Abstract
Aim: To study the level of thyroid-stimulating and thyroid hormones in pregnant women with obesity and their newborns.
Materials and Methods. We consecutively recruited 40 pregnant women and their newborns. Blood sampling in pregnant women was carried out at the end of the third trimester 12 hours after the last meal while in newborns it was conducted immediately after birth. Measurement of serum thyroid-stimulating hormone, thyroxine, triiodothyronine, and free thyroxine was performed using chemiluminescent immunoassay.
Results. Thyroid disease was significantly more common in pregnant women with obesity. Clinical and latent hypothyroidism in obese pregnant women was observed 1.5-fold more frequently as compared with those having normal body weight. In keeping with these findings, goiter and elevated thyroxine were also more common in obese pregnant women. Newborns from obese women were more often characterized by a transient hypothyroidism in combination with an augmented thyroid-stimulating hormone.
Conclusion. Levels of thyroid-stimulating and thyroid hormones in obese pregnant women and their newborns significantly differ from the patients with normal body weight.
About the Authors
O. B. Karelina
Kemerovo State Medical University
Russian Federation
Russian Federation
Olga B. Karelina, Dr, MD, PhD, Associate Professor, Department of Obstetrics and Gynecology
22a, Voroshilova Street, Kemerovo, 650056
N. V. Artymuk
Kemerovo State Medical University
Russian Federation
Russian Federation
Natalia V. Artymuk, Prof., MD, DSc, Head of the Department of Obstetrics and Gynecology
22a, Voroshilova Street, Kemerovo, 650056
O. A. Tachkova
Kemerovo State Medical University
Russian Federation
Russian Federation
Olga A. Tachkova, Dr, MD, PhD, Associate Professor, Department of Hospital Therapy and Clinical Pharmacology
22a, Voroshilova Street, Kemerovo, 650056
T. Yu. Marochko
Kemerovo State Medical University
Russian Federation
Russian Federation
Tatiana Yu. Marochko, Dr, MD, PhD, Associate Professor, Department of Obstetrics and Gynecology, Kemerovo State Medical University (22a, Voroshilova Street
22a, Voroshilova Street, Kemerovo, 650056
M. N. Surina
Kemerovo State Medical University
Russian Federation
Russian Federation
Maria N. Surina, Dr, MD, PhD, Associate Professor, Department of Obstetrics and Gynecology
22a, Voroshilova Street, Kemerovo, 650056
References
1. Artymuk NV, Tachkova OA, Shurygin SN. The Reproductive Vicious Cycle of Obesity: Review of the Literature. Doctor.Ru. 2018;10(154):22-26. (In Russ.). DOI: 10.31550/1727-2378-2018-154-10-22-26
2. Karelina OB, Artymuk NV. The birth-rate of the Kemerovo region: main causes, risk factors, problems of rendering assistance. Women's health and reproduction. 2019;2(33):3-4. (In Russ.). http://journal.gynecology.school/statyi/mertvorozhdaemost-v-kemerov
3. Tachkova OA, Artymuk NV, Suturina LV. Pregnancy and Delivery after surgical treatment of obesity. Fundamental and clinical medicine. 2018;3(3):97-100. (In Russ.).
4. Jendokrinnye zabolevanija i beremennost' v voprosah i otvetah. Rukovodstvo dlja vrachej. Pod red. Dedova I.I., Burumkulovoj F.F. M.: E-noto; 2015:132-133. (In Russ.).
5. Infekcii, peredavaemye polovym putem. Pod red. Akovbjana V.A, Prohorenkova V.I., Sokolovskogo E.V. M.: Izdatel'stvo Media Sfera; 2007:11-33. (In Russ.).
6. Karelina OB, Artymuk NV. Sistema mat'-placenta-plod u zhenshhin s gipotalamicheskim sindromom. Mother and Baby in Kuzbass. 2007;4(31):3-9. (In Russ.).
7. Karelina OB, Artymuk NV. Leptin Serum Level in Women with obesity do Not Define Leptin Cord Blood Level in Their Newborns. Fundamental and clinical medicine. 2017;2(3):21-27. (In Russ.).
8. Zaharova S.M., Savel'eva L.V., Fadeeva M.I. Ozhirenie i gipotireoz. Ozhirenie i metabolizm. 2013;10(2):54-58. (In Russ.).
9. Knight BA, Shields BM, Hattersley AT, Vaidya B. Maternal hypothyroxinaemia in pregnancy is associated with obesity and adverse maternal metabolic parameters. Eur J Endocrinol. 2016;174(1):5157. DOI: 10.1530/EJE-15-0866. PMID: 26586839
10. Mosso L, Martínez A, Rojas MP, Latorre G, Margozzini P, Lyng T, Carvajal J, Campusano C, Arteaga E, Boucai L. Early pregnancy thyroid hormone reference ranges in Chileanwomen: the influence of body mass index. Clin Endocrinol (Oxf). 2016;85(6):942-948. DOI: 10.1111/cen.13127
11. Collares FM, Korevaar TIM, Hofman A, Steegers EAP, Peeters RP4, Jaddoe VWV, Gaillard R. Maternal thyroid function, prepregnancy obesity and gestational weight gain-The Generation R Study: A prospective cohort study.Clin Endocrinol (Oxf). 2017;87(6):799806. DOI: 10.1111/cen.13412.
12. Pop VJ, Biondi B, Wijnen HA, Kuppens SM, Lvader H. Maternal thyroid parameters, body mass index and subsequent weight gain during pregnancy in healthy euthyroid women. Clin Endocrinol (Oxf). 2013;79(4):577-583. DOI: doi: 10.1111/cen.12177
13. Kahr MK, Antony KM, DelBeccaro M, Hu M, Aagaard KM, Suter MA. Increasing maternal obesity is associated with alterations in both maternal and neonatal thyroid hormone levels. Clin Endocrinol (Oxf). 2016; 84(4):551-557. DOI: 10.1111/cen.12974.
Review
For citations:
Karelina O.B., Artymuk N.V., Tachkova O.A., Marochko T.Yu., Surina M.N. Levels of thyroid-stimulating and thyroid hormones in pregnant women with obesity and their newborns. Fundamental and Clinical Medicine. 2019;4(4):58-63. (In Russ.) https://doi.org/10.23946/2500-0764-2019-4-4-58-63
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