Age and gender distribution among the patients with Gilbert’s syndrome
https://doi.org/10.23946/2500-0764-2021-6-1-75-81
Abstract
Aim. To analyze age and gender distribution in patients with Gilbert's syndrome.
Materials and Methods. We consecutively recruited 115 patients with Gilbert's syndrome. All patients underwent genotyping of the rs8175347 polymorphism within the UGT1A1 gene using allele-specific polymerase chain reaction to confirm the diagnosis.
Results. The age of initial diagnosis ranged from 3 years to 71 years, with the majority (44.3%) of cases detected ≤ 20 years of age. Mean ± standard error and median age of the diagnosis were 30.03 ± 1.72 years and 23 years. Despite the proportion of females and males among patients was similar, age distribution at primary diagnosis was significantly different across the genders. In women, Gilbert's syndrome was most frequently detected between 11 and 20 years (23.1%) and between 51 and 60 years (19.2%). In contrast, male adolescents were more prone to the development of Gilbert's syndrome, as 47.6% of male patients belonged to this age category.
Conclusions. Variable age of Gilbert's syndrome diagnosis is probably determined by an individual combination of genetic causes (e.g., mutation of the UGT1A1 gene) and additional risk factors. Adolescents compose a significant proportion of patients. Because of relatively mild disease in many patients and unpredictability of the provoking factors, primary detection of Gilbert's syndrome can be delayed. Differences in age of Gilbert's syndrome diagnosis across the genders can be partially explained by organizational reasons associated with the current screening programs.
About the Authors
A. N. Volkov
Kemerovo State Medical University
Russian Federation
Russian Federation
PhD, Associate Professor, Department of Biology, Genetics and Parasitology; Senior Research Fellow, Central Research
Laboratory,
22a, Voroshilova Street, Kemerovo, 650056
E. V. Tsurkan
Belyaev Kuzbass Regional Clinical Hospital
Russian Federation
Russian Federation
Biologist,
22, Oktyabrskiy Prospekt, Kemerovo, 650066
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Review
For citations:
Volkov A.N., Tsurkan E.V. Age and gender distribution among the patients with Gilbert’s syndrome. Fundamental and Clinical Medicine. 2021;6(2):75-81. (In Russ.) https://doi.org/10.23946/2500-0764-2021-6-1-75-81
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