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HOW TO ANALYZE AND PRESENT GENETIC EPIDEMIOLOGY DATA IN CANDIDATE STUDIES

Abstract

Here we describe recent trends in statistical analysis and data presentation in candidate genetic association studies. We first discuss methods of genetic epidemiology following talking about the three key steps in candidate genetic association studies: 1) study design; 2) isolation of biomaterial, DNA extraction and genotyping; 3) statistical analysis and data presentation. In addition, we consider the crucial issues of these studies from the reviewer’s point of view.

About the Authors

ANTON G. Kutikhin
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation


ARSENIY E. Yuzhalin
Department of Oncology, Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, University of Oxford
Russian Federation


ANASTASIA V. Ponasenko
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation


References

1. Ponasenko A.V., Khutornaya M.V., Kutikhin A.G., Rutkovskaya N.V., Tsepokina A.V., Kondyukova N.V., Yuzhalin A.E., Barbarash L.S. A Genomics-Based Model for Prediction of Severe Bioprosthetic Mitral Valve Calcification. Int J Mol Sci. 2016;17 (9). pii: E1385.

2. Kutikhin A.G., Ponasenko A.V., Khutornaya M.V., Yuzhalin A.E., Zhidkova I.I., Salakhov R.R., Golovkin A.S., Barbarash O.L., Barbarash L.S.. Association of TLR and TREM-1 gene polymorphisms with atherosclerosis severity in a Russian population. Meta Gene. 2016; 9: 76-89.

3. Golovkin A.S., Ponasenko A.V., Yuzhalin A.E., Salakhov R.R., Khutornaya M.V., Kutikhin A.G., Rutkovskaya N.V., Savostyanova Y.Y., Barbarash L.S. An association between single nucleotide polymorphisms within TLR and TREM-1 genes and infective endocarditis. Cytokine. 2015; 71 (1):16-21.

4. Golovkin A.S., Ponasenko A.V., Khutornaya M.V., Kutikhin A.G., Salakhov R.R., Yuzhalin A.E., Zhidkova I.I., Barbarash O.L., Barbarash L.S. Association of TLR and TREM-1 gene polymorphisms with risk of coronary artery disease in a Russian population. Gene. 2014; 550 (1): 101-109.

5. Kutikhin A.G., Yuzhalin A.E., Volkov A.N., Zhivotovskiy A.S., Brusina E.B. Correlation between genetic polymorphisms within IL-1B and TLR4 genes and cancer risk in a Russian population: a case-control study. Tumour Biol. 2014; 35 (5): 4821-4830.


Review

For citations:


Kutikhin A.G., Yuzhalin A.E., Ponasenko A.V. HOW TO ANALYZE AND PRESENT GENETIC EPIDEMIOLOGY DATA IN CANDIDATE STUDIES. Fundamental and Clinical Medicine. 2017;2(2):77-82. (In Russ.)

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ISSN 2500-0764 (Print)
ISSN 2542-0941 (Online)