BONE TURNOVER MARKERS IN MALE PATIENTS WITH CORONARY ARTERY DISEASE

Aim: Тo study the bone turnover markers (BTMs) in male patients with coronary artery disease (CAD). Materials and Methods: We recruited 102 male patients with CAD (mean age 60.8±6.9 years) and performed coronary angiography along with a multislice computed tomography following the measurement of BTMs (osteocalcin, bone alkaline phosphatase (BAP), and cathepsin K). Coronary artery calcification was evaluated by Agatston score. Results: We found a significant increase in serum levels of BAP and cathepsin K in patients with CAD compared to the healthy controls, indicating a high rate of bone metabolism. Serum levels of BAP and osteocalcin were significantly higher in patients with severe coronary artery calcification in comparison with those without calcification. Serum level of cathepsin K was significantly lower in patients with a high risk of fatal coronary events compared to those with a low risk. Conclusions: Increase in BTMs in male patients with CAD indicates a high rate of bone loss that may confirm the common mechanisms of bone resorption and vascular calcification.

ишемическая болезнь сердца, остеопороз, кальциноз, катепсин К, костная щелочная фосфатаза, остеокальцин, coronary heart disease, osteoporosis, calcification, catepsin K, bone akaline phosphatase, osteocalcin

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