Immune response, smoking, and lung cancer: a systematic review
https://doi.org/10.23946/2500-0764-2024-9-3-86-97
Abstract
Here we review the role of innate and adaptive immunity at ascending lung cancer stages in smoking and non-smoking patients. T cell activity and the expression of pro-inflammatory cytokines were found to be elevated in smokers. As a consequence, smoking has been identified as a significant risk factor promoting lung carcinogenesis. Further experimental research in this area will allow the development of novel diagnostic approaches, including circulating biomarkers and personalised medicine.
About the Authors
V. Yu. BuslaevRussian Federation
Mr. Vladislav Yu. Buslaev, Leading Engineer, Laboratory of Cytogenetics
10, Leningradskiy Prospekt, Kemerovo, 650056
A. V. Minin
Russian Federation
Mr. Artem V. Minin, Engineer, Laboratory of Cytogenetics; ; PhD Student, Department of Genetics and Basic Medicine
10, Leningradskiy Prospekt, Kemerovo, 650056; 6, Krasnaya Street, Kemerovo, 650056
M. V. Katanakhova
Russian Federation
Mrs. Margarita V. Katanakhova, Engineer, Laboratory of Cytogenetics; PhD Student, Department of Genetics and Basic Medicine
10, Leningradskiy Prospekt, Kemerovo, 650056; 6, Krasnaya Street, Kemerovo, 650056
A. V. Shabaldin
Russian Federation
Prof. Andrey V. Shabaldin, MD, PhD, Professor, Department of Polyclinic Pediatrics, Introduction to Pediatrics and Postgraduate Training; Professor, Department of Genetics and Basic Medicine
22a, Voroshilova Street, Kemerovo, 650056; 6, Krasnaya Street, Kemerovo, 650056
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Review
For citations:
Buslaev V.Yu., Minin A.V., Katanakhova M.V., Shabaldin A.V. Immune response, smoking, and lung cancer: a systematic review. Fundamental and Clinical Medicine. 2024;9(3):86-97. (In Russ.) https://doi.org/10.23946/2500-0764-2024-9-3-86-97