The effectiveness of target echocardiography for the treatment of left ventricular myocardial hypertrophy in a premature newborn with shock
https://doi.org/10.23946/2500-0764-2025-10-4-101-109
Abstract
Aim. To present a clinical case of myocardial hypertrophy with intracavitary left ventricular obstruction in a premature newborn. Materials and Methods. The article describes a clinical case of myocardial hypertrophy with left intraventricular cardiac obstruction. Myocardial hypertrophy with left intraventricular cardiac obstruction in newborns is a life-threatening condition requiring timely diagnosis and therapy. Results. One of the means of diagnosing and monitoring this condition is target echocardiography, which allows it to be diagnosed, to correct hemodynamic components and to evaluate the effectiveness of therapy, including the use of beta-blockers. Myocardial hypertrophy with left intraventricular cardiac obstruction was diagnosed based on an ultrasound picture of thickening of the myocardial walls and the presence of an intraventricular gradient of 11 mmHg. The hemodynamic profile of this condition was characterized by a decrease in preload and postload, as well as an increase in myocardial contractility. Treatment included increased liquid load, the use of the vasopressor norepinephrine, and the administration of the beta-blocker atenolol. Against the background of the therapy, regression of the obstruction of the excretory tract of the left ventricle and clinical stabilization of the child were achieved. Conclusion. Target echocardiography has demonstrated its clinical effectiveness in the detection and control of therapy for myocardial hypertrophy with left intraventricular cardiac obstruction.
About the Authors
A. A. ZadvornovRussian Federation
Aleksej A. Zadvornov ✉, MD, Cand. Sci. (Medicine), anesthesiologist and intensive care physician, neonatal intensive care unit
Voroshilova street,21, Kemerovo, 650056, Russia
A. A. Chernykh
Russian Federation
Artem A. Chernykh, MD, Cand. Sci. (Medicine), Associate Professor, anesthesiologist and intensive care physician, Head of the neonatal intensive care unit
Voroshilova street,21, Kemerovo, 650056, Russia
E. V. Grigoriev
Russian Federation
Evgenij V. Grigoriev, MD, Corresponding Member of RAS, Dr. Sci. (Medicine), Professor, Head of the Department of Anesthesiology, Intensive Care
Voroshilova Street, 22a, Kemerovo, 650056, Russia
References
1. Kovtun OP, Tsyvian PB, Markova TV, Chumarnaya TV. Remodeling of the Heart of the Premature Child. Annals of the Russian Academy of Medical Sciences. 2020;75(6):631–637. (in Russ). https://doi.org/10.15690/vramn1268
2. Rudakova AA, Ionov OV, Filippova EA, Sugak AB, Kirtbaya AR, Balashova EN, et al. Possibilities and limitations of the use of echocardiography by an intensive care physician in neonatal intensive care. Neonatologiya: novosti, mneniya, obuchenie. 2022;10(4):54–62. (in Russ). 10.33029/2308-2402-2022-10-4-54-62
3. Choudhry S., Salter A., Cunningham T. W., Levy P. T., Hackett B. P., Singh G. K., et al. Risk factors and prognostic significance of altered left ventricular geometry in preterm infants. J. Perinatol. 2018;38(5):543–549. https://doi.org/10.1038/s41372-018-0047-5
4. Paauw N. D., Stegeman R., de Vroede M. A M J, Termote J. U M, Freund M. W., Breur J. M P J. Neonatal cardiac hypertrophy: the role of hyperinsulinism-a review of literature. Eur. J. Pediatr. 2020;179(1):39–50. https://doi.org/ 10.1007/s00431-019-03521-6
5. Crispi F., Sepúlveda-Martínez Á., Crovetto F., Gómez O., Bijnens B., Gratacós E. Main Patterns of Fetal Cardiac Remodeling. Fetal Diagn. Ther. 2020;47(5):337–344. https://doi.org/10.1159/000506047
6. Gruendler K., Schwarz C. E., Lorenz L., Poets C. F., Franz A. R. Beta blocker therapy in recipients of twin-to-twin transfusion syndrome. Arch. Dis. Child. Fetal Neonatal Ed. 2019;104(5):F541–F543. https://doi.org/10.1136/archdischild-2017-314497
7. D'Alto M., Russo M. G., Pacileo G., Paladini D., Romeo E., Sarubbi B., et al. Left ventricular remodelling in outflow tract obstructive lesions during fetal life. J. Cardiovasc. Med. (Hagerstown). 2006;7(10):726–730. https://doi.org/10.2459/01.JCM.0000247318.27041.1e
8. Julian C. G., Pedersen B. S., Salmon C. S., Yang I. V., Gonzales M., Vargas E., et al. Unique DNA Methylation Patterns in Offspring of Hypertensive Pregnancy. Clin. Transl. Sci. 2015;8(6):740–745. https://doi.org/10.1111/cts.12346
9. Yamaguchi S., Shimabukuro M., Abe M., Arakaki T., Arasaki O., Ueda S. Comparison of the prognostic values of three calculation methods for echocardiographic relative wall thickness in acute decompensated heart failure. Cardiovasc. Ultrasound. 2019;17(1):30. https://doi.org/10.1186/s12947-019-0179-6
10. Lang R. M., Bierig M., Devereux R. B., Flachskampf F. A., Foster E., Pellikka P.A., et al. Recommendations for chamber quantification. Eur. J. Echocardiogr. 2006;7(2):79–108. https://doi.org/10.1016/j.euje.2005.12.014
11. Paech C., Wolf N., Thome U. H., Knüpfer M. Hypertrophic intraventricular flow obstruction after very-low-dose dexamethasone (Minidex) in preterm infants: case presentation and review of the literature. J. Perinatol. 2014;34(3):244–246. https://doi.org/10.1038/jp.2013.171
12. Furck A. K., Desai A., Macrae D. J., Slavik Z. Novel postoperative use of beta-blocking medication for infants with left ventricular outflow obstruction and diastolic myocardial dysfunction. Pediatr. Cardiol. 2012;33(8):1450–1452. https://doi.org/10.1007/s00246-012-0271-2
Review
For citations:
Zadvornov A.A., Chernykh A.A., Grigoriev E.V. The effectiveness of target echocardiography for the treatment of left ventricular myocardial hypertrophy in a premature newborn with shock. Fundamental and Clinical Medicine. 2025;10(4):101-109. (In Russ.) https://doi.org/10.23946/2500-0764-2025-10-4-101-109





























