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Aspects of using multitasking training in patients with cardiac surger

https://doi.org/10.23946/2500-0764-2026-11-2-49-57

Abstract

Aim. Conduct an analytical review of current evidence regarding postoperative cognitive dysfunction (POCD) in cardiac patients and evaluate the potential of multitasking trainings as a way of cognitive rehabilitation.
Materials and methods. For this systematic review, contemporary domestic and foreign literature sources were searched in PubMed, Google Scholar, CyberLeninka, eLibrary databases, including original studies, systematic reviews, and meta-analyses addressing pathogenesis, diagnosis, POCD risk factors, and cognitive rehabilitation techniques, with a focus on computer-based multitasking trainings, including those with using virtual reality (VR) technologies.
Results. The pathogenesis of the interaction of cardiovascular diseases and cognitive disorders was analyzed, key risk factors for the development of POKD were identified. It has been shown that modern approaches to rehabilitation, in particular multitasking trainings (the method of "double tasks") and VR technologies, have significant potential. They contribute to the stimulation of neuroplasticity, activation of extensive neural networks, improvement of cognitive functions (attention, memory, control functions) and can reduce the frequency and severity of POKD. Data from studies demonstrating neurophysiological and biochemical improvements (e.g., increased BDNF) in patients following such trainings are presented.
Conclusion. The use of multitasking training, especially in the format of computer programs and the use of virtual reality technologies, is a promising non-pharmacological personalized approach to the prevention and correction of POCD in cardiac patients. For widespread implementation in clinical practice, the development of unified protocols and further research are necessary.

About the Authors

Т. B. Temnikova
Research Institute for Complex Issues of Cardiovascular Diseases; Kemerovo State Medical University
Russian Federation

Dr. Тatyana B. Temnikova, MD, Cand. Sci. (Medicine), Junior Research Assistant, Laboratory of Neurovascular Pathology, Senior Lecturer of the Department of Cardiology and Cardiovascular Surgery

Barbarash Boulevard, 6, Kemerovo, 650002
Voroshilova Street, 22A, Kemerovo, 650056

 



O. A. Trubnikova
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation

Dr. Olga A. Trubnikova, MD, Dr. Sci. (Medicine), Head of the Laboratory for Neurovascular Pathology, Department of Clinical Cardiology

Barbarash Boulevard, 6, Kemerovo, 650002



O. L. Barbarash
Research Institute for Complex Issues of Cardiovascular Diseases; Kemerovo State Medical University
Russian Federation

Prof. Olga L. Barbarash, MD, Academician of the Russian Academy of Sciences, Dr. Sci. (Medicine), Professor, Head of the Department of Cardiology and Cardiovascular Surgery, Director

Barbarash Boulevard, 6, Kemerovo, 650002
Voroshilova Street, 22A, Kemerovo, 650056

 



References

1. Boytsov SA, Provatorov SI. Possibilities of dispensary observation in reducing mortality from coronary heart disease. Terapevticheskii Arkhiv. 2023;95(1):5–10. (In Russ.). https://doi.org/10.26442/00403660.2023.01.202038

2. Zakharov VV, Chernousov PA, Vekhova KA, Bogolepova AN. Cognitive impairment in patients with arterial hypertension. S.S. Korsakov Journal of Neurology and Psychiatry = Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2024;124(4(2):1–8. (In Russ.). https://doi.org/10.17116/jnevro20241240421

3. Suvila K, Lima JAC, Yano Y, Tan ZS, Cheng S, Niiranen TJ. Early-but Not Late-Onset Hypertension Is Related to Midlife Cognitive Function. Hypertension. 2021;77(3):972–979. https://doi.org/10.1161/Hypertensionaha.120.16556

4. Malavasi VL, Zoccali C, Brandi MC, Micali G, Vitolo M, Imberti JF, et al. Cognitive impairment in patients with atrial fibrillation: Implications for outcome in a cohort study. Int J Cardiol. 2021;323:83–89. https://doi.org/10.1016/j.ijcard.2020.08.028

5. Faulkner KM, Uchmanowicz I, Lisiak M, Cichoń E, Cyrkot T, Szczepanowski R. Cognition and Frailty in Patients With Heart Failure: A Systematic Review of the Association Between Frailty and Cognitive Impairment. Front Psychiatry. 2021;12:713386. https://doi.org/10.3389/fpsyt.2021.713386

6. Bogolepova AN, Vasenina EE, Gomzyakova NA, Gusev EI, Dudchenko NG, Emelin AYu, et al. Clinical Guidelines for Cognitive Disorders in Elderly and Older Patients. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(10 3):6 137. (In Russ.). https://doi.org/10.17116/jnevro20211211036

7. Trubnikova OA, Tarasova IV, Moskin EG, Kupriyanova DS, Argunova YA, Pomeshkina SA, et al. Beneficial effects of a short course of physical prehabilitation on neurophysiological functioning and neurovascular biomarkers in patients undergoing coronary artery bypass grafting. Front Aging Neurosci. 2021;13:699259. https://doi.org/10.3389/fnagi.2021.699259

8. Patnode CD, Perdue LA, Rossom RC, Rushkin MC, Redmond N, Thomas RG, et al. Screening for Cognitive Impairment in Older Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force. JAMA. 2020;323(8):764–785. https:// doi.org/10.1001/jama.2019.22258

9. Vu T, Smith JA. An Update on postoperative cognitive dysfunction following cardiac surgery. Front Psychiatry. 2022;13:884907. https://doi.org/10.3389/fpsyt.2022.884907

10. Zhao Q, Wan H, Pan H, Xu Y. Postoperative cognitive dysfunction-current research progress. Front Behav Neurosci. 2024;18:1328790. https://doi.org/10.3389/fnbeh.2024.1328790

11. Greaves D, Psaltis PJ, Davis DHJ, Ross TJ, Ghezzi ES, Lampit A, et al. Risk Factors for Delirium and Cognitive Decline Following Coronary Artery Bypass Grafting Surgery: A Systematic Review and Meta-Analysis. J A. Heart Assoc. 2020;9(22):e017275. https://doi.org/10.1161/JAHA.120.017275

12. Tarasov VO, Denisenko SM, Talipova RV, Syropyatova SA, Shadrina KA, Alekseev VA, et al. Preoperative risk factors of postoperative delirium development in cardiac surgical interventions (review). Ural Medical Journal. 2020;11(194):46–51. (In Russ.). https://doi.org/10.25694/URMJ.2020.11.17

13. Arefayne NR, Berhe YW, van Zundert AA. Incidence and factors related to prolonged postoperative cognitive decline (POCD) in elderly patients following surgery and anaesthesia: A systematic review. J Multidisci Healthc. 2023;16:3405–3413. https://doi.org/1922310.2147/JMDH.S431168

14. Liu J, Huang K, Zhu B, Zhou B, Ahmad Harb AK, Liu L, et al. Neuropsychological tests in post-operative cognitive dysfunction: methods and applications. Fron Psychol. 2021;12:684307. https://doi.org/10.3389/fpsyg.2021.684307

15. Travica N, Lotfaliany M, Marriott A, Safavynia SA, Lane MM, Gray L, et al. Peri-operative risk factors associated with post-operative cognitive dysfunction (POCD): An umbrella review of meta-analyses of observational studies. J Clin Med. 2023;12(4):1610. https://doi.org/10.3390/jcm12041610

16. Zhang S, Liu C, Sun J, Li Y, Lu J, Xiong X, et al. Bridging the gap: Investigating the link between inflammasomes and postoperative cognitive dysfunction. Aging Dis. 2023;14(6):1981–2002. https://doi.org/10.14336/AD.2023.0501

17. Fujii Y. Evaluation of Inflammation Caused by Cardiopulmonary Bypass in a Small Animal Model. Biology. 2020;9(4):81. https://doi.org/10.3390/biology9040081

18. Xiao QX, Cheng CX, Deng R, Liu Q, Ren YB, He L, et al. LncRNA-MYL2-2 and miR-124-3p Are Associated with Perioperative Neurocognitive Disorders in Patients after Cardiac Surgery. J Invest Surg. 2021;34(12):1297–1303. https://doi.org/10.1080/08941939.2020

19. Greaves D, Psaltis PJ, Davis DHJ, Ross TJ, Ghezzi ES, Lampit A, et al. Risk Factors for Delirium and Cognitive Decline Following Coronary Artery Bypass Grafting Surgery: A Systematic Review and Meta-Analysis. J Am Heart Assoc. 2020;9(22):e017275. https://doi.org/10.1161/JAHA.120.017275

20. Zeng K, Long J, Li Y, Hu J. Preventing postoperative cognitive dysfunction using anesthetic drugs in elderly patients undergoing noncardiac surgery: a systematic review and meta-analysis. Int J Surg. 2023;109(1):21–31. https://doi.org/10.1097/JS9.0000000000000001

21. Yuan SM, Lin H. Postoperative Cognitive Dysfunction after Coronary Artery Bypass Grafting. Braz J Cardiovasc Surg. 2019;34(1):76–84. https://doi.org/10.21470/1678-9741-2018-0165

22. Zoupa E, Bogiatzidou O, Siokas V, Liampas I, Tzeferakos G, Mavreas V, et al. Cognitive Rehabilitation in Schizophrenia-Associated Cognitive Impairment: A Review. Neurol Int. 2022;15(1):12–23. https://doi.org/10.3390/neurolint15010002

23. Vas A, Luedtke A, Ortiz E, Mackie N, Gonzalez S. Cognitive Rehabilitation: Mild Traumatic Brain Injury and Relevance of OTPF. Occup Ther Int. 2023;2023:8135592. https://doi.org/10.1155/2023/8135592

24. Zlobina YuV, Epaneshnikova NV, Zinovieva NP. Efficiencyof Cognitive Trainings in Patientswith Acute Brain Circulation in the Acute Period: Pilot Study. Bulletin of the South Ural State University, Ser. Psychology. 2018;11(3):64–73. (In Russ.). https://doi.org/10.14529/psy180308

25. Rute-Pérez S, Rodríguez-Domínguez C, Vélez-Coto M, Pérez-García M, Caracuel A. Effectiveness of Computerized Cognitive Training by VIRTRAEL on Memory and Executive Function in Older People: A Pilot Study. Brain Sci. 2023;13(4):684. https://doi.org/10.3390/brainsci13040684

26. Bernini S, Panzarasa S, Barbieri M, Sinforiani E, Quaglini S, Tassorelli C, et al. A double-blind randomized controlled trial of the efficacy of cognitive training delivered using two different methods in mild cognitive impairment in Parkinson's disease: preliminary report of benefits associated with the use of a computerized tool. Aging Clin Exp Res. 2021;33(6):1567–1575. https://doi.org/10.1007/s40520-020-01665-2

27. Li R, Geng J, Yang R, Ge Y, Hesketh T. Effectiveness of Computerized Cognitive Training in Delaying Cognitive Function Decline in People With Mild Cognitive Impairment: Systematic Review and Meta-analysis. J Med Internet Res. 2022;24(10):e38624. https://doi.org/10.2196/38624

28. Wu J, He Y, Liang S, Liu Z, Huang J, Liu W, et al. Effects of computerized cognitive training on structure‒function coupling and topology of multiple brain networks in people with mild cognitive impairment: a randomized controlled trial. Alzheimers Res Ther. 2023;15(1):158. https://doi.org/10.1186/s13195-023-01292-9

29. Broadhouse KM, Singh MF, Suo C, Gates N, Wen W, Brodaty H, et al. Hippocampal plasticity underpins long-term cognitive gains from resistance exercise in MCI. Neuroimage Clin. 2020;25:102182. https:// doi.org/10.1016/j.nicl.2020.102182

30. Eryomina OV, Petrova MM, Prokopenko SV, Mozheyko EY, Kaskaeva DS, Gavrilyuk OA. The effectiveness of the correction of cognitive impairment using computer-based stimulation programs for patients with coronary heart disease after coronary bypass surgery. J Neurol Sci. 2015;358(1-2):188–192. https://doi.org/10.1016/j.jns.2015.08.1535

31. Ellis ML, Edwards JD, Peterson L, Roker R, Athilingam P. Effects of Cognitive Speed of Processing Training Among Older Adults With Heart Failure. J Aging Health. 2014;26(4):600–615. https://doi.org/10.1177/0898264314525666

32. Petrigna L, Thomas E, Gentile A, Paoli A, Pajaujiene S, Palma A, et al. The evaluation of dual-task conditions on static postural control in the older adults: a systematic review and meta-analysis protocol. Syst Rev. 2019;8(1):188. https://doi.org/10.1186/s13643-019-1107-4

33. Gheysen F, Poppe L, DeSmet A, Swinnen S, Cardon G, De Bourdeaudhuij I, et al. Physical activity to improve cognition in older adults: can physical activity programs enriched with cognitive challenges enhance the effects? A systematic review and meta-analysis. Int J Behav Nutr Phys Act. 2018;15(1):63. https://doi.org/10.1186/s12966-018-0697-x

34. Trubnikova OA, Tarasova IV, Barbarash OL. Neurophysiological mechanisms and perspective for the use of dual tasks inrecovering cognitive function after cardiac surgery. Fundamental and Clinical Medicine. 2020;5(2):101–111. (In Russ.). https://doi.org/10.23946/2500-0764-2020-5-1-101-111

35. Trubnikova OA, Tarasova IV, Kukhareva IN, Temnikova TB, Sosnina AS, Syrova ID, et al. Effectiveness of dual-task computerized cognitive training in the prevention of postoperative cognitive dysfunction in coronary bypass surgery. Cardiovascular Therapy and Prevention. 2022;21(8):3320. (In Russ.). https://doi.org/10.15829/1728-8800-2022-3320

36. Trubnikova OA, Tarasova IV, Temnikova TB, Kupriyanova DS, Kukhareva IN, Sosnina AS, et al. A comparative assessment of neurochemical and neurophysiological parameters of cardiac surgery patients who underwent different versions of multitasking cognitive training. SS Korsakov Journal of Neurology and Psychiatry. 2024;124(12):62 68. (In Russ.). https://doi.org/10.17116/jnevro202412412162

37. Kouijzer MMTE, Kip H, Bouman YHA, Kelders SM. Implementation of virtual reality in healthcare: a scoping review on the implementation process of virtual reality in various healthcare settings. Implement Sci Commun. 2023;4(1):67. https://doi.org/10.1186/s43058-023-00442-2

38. Zakharov AV, Khivintseva EV, Chaplygin SS, Starikovsky MYu, Elizarov MA, Kolsanov AV. Motor rehabilitation of patients in the acute period of stroke using virtual reality technology. SS Korsakov Journal of Neurology and Psychiatry. 2021;121(8‑2):71–75. (In Russ.). https:// doi.org/10.17116/jnevro202112108271

39. Turovinina EF, Plotnikov DN. Rehabilitation of patients with ischemic stroke using virtual reality: a prospective randomized study. Bulletin of Rehabilitation Medicine. 2025;24(4):54–66. (In Russ.). https://doi.org/10.38025/2078-1962-2025-24-4-54-66

40. Dyachenko DA, Kovalenko AA, Vasiliev YuL. Experience and prospects of using virtual reality technologies in medicine. Medical alphabet. 2023;(16):82–86. (In Russ.). https://doi.org/10.33667/2078-5631-2023-16-82-86

41. Tran JE, Fowler CA, Delikat J, Kaplan H, Merzier MM, Schlesinger MR, et al. Immersive virtual reality to improve outcomes in veterans with stroke: Protocol for a single-arm pilot study. JMIR Res Protoc. 2021;10(5):e26133. https://doi.org/10.2196/26133

42. Nikolaev VA, Nikolaev AA. Virtual, augmented and mixed reality technologies in the context of digitalization of healthcare system. Medical Technologies. Assessment and Choice. 2020;(2):35 42. (In Russ.). https://doi.org/10.17116/medtech20204002135

43. Hendricks TM, Gutierrez CN, Stulak J.M, Dearani JA, Miller JD. The use of virtual reality to reduce preoperative anxiety in first-time sternotomy patients: a randomized controlled pilot trial. Mayo Clin Proc. 2020;95(6):1148–1157. https://doi.org/10.1016/j.mayocp.2020.02.032

44. Razumnikova OM, Trubnikova OA. Use of virtual reality technologies to restore cognitive functions and quality of life: an application for cardiac patients with brain ischemia. Complex Issues of Cardiovascular Diseases. 2023;12(4):133–148. (In Russ.). https://doi.org/10.17802/2306-1278-2023-12-4-133-148

45. Bouraghi H, Mohammadpour A, Khodaveisi T, Ghazisaeedi M, Saeedi S, Familgarosian S. Virtual Reality and Cardiac Diseases: A Systematic Review of Applications and Effects. J Healthc Eng. 2023;2023:8171057. https://doi.org/10.1155/2023/8171057

46. Trubnikova OA, Tarasova IV, Kukhareva IN, Kupriyanova DS, Gorbatovskaya EE, Sosnina AS, et al. The changes in neurophysiological parameters and neurovascular unit markers in cardiac surgery patients under the influence of multitask training in a three-dimensional environment. Complex issues of cardiovascular diseases. 2024;13(4s):52–64. (in Russ.). https://doi.org/10.17802/2306-1278-2024-13-4s-52-64

47. Bofanova NS, Tychkov AYu, Khanfar YaA, Zolotarev RV. Virtual reality technology as a promising direction in neurorehabilitation. SS Korsakov Journal of Neurology and Psychiatry. 2023;123(1):131–136. (In Russ.). https://doi.org/10.17116/jnevro202312301113.


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For citations:


Temnikova Т.B., Trubnikova O.A., Barbarash O.L. Aspects of using multitasking training in patients with cardiac surger. Fundamental and Clinical Medicine. 2026;11(2):49-57. (In Russ.) https://doi.org/10.23946/2500-0764-2026-11-2-49-57

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