EFFECTS OF ANTI-INFLAMMATORY THERAPY ON BONE MINERAL DENSITY IN PATIENTS WITH ANKYLOSING SPONDYLITIS: RESULTS OF PROSPECTIVE STUDY

Abstract

Aim: To perform a cytogenetic profiling of patients with spring-summer tick-borne encephalitis. Materials and Methods: Cytogenetic profiling of 22 patients with spring-summer tick-borne encephalitis was carried out using a conventional technique immediately after a hospital admission and 30, 60, and 180 days after a hospital dischargeControl group included healthy blood donors. Results: Frequency of cells with chromosomal abnormalities was significantly higher in patients with spring-summer tick-borne encephalitis compared to the controls, particularly at the early stage. Cytogenetic profile became normal only 6 months after hospital discharge. The majority of the aneuploid cells were hypoploid; the most frequently lacking chromosomes were of D and G groups. Chromatid breaks were the most frequent type of the structural chromosomal aberrations. The highest frequency of the structural chromosomal aberrations was observed in the chromosome 2. Conclusions: Spring-summer tick-borne encephalitis is associated with a high frequency of cytogenetic abnormalities within 3 months after hospital discharge. Cytogenetic profile becomes normal only 6 months after hospital discharge.