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ПОЛИОРГАННАЯ НЕДОСТАТОЧНОСТЬ В ПРАКТИКЕ ПЕДИАТРИЧЕСКОЙ РЕАНИМАТОЛОГИИ: ОБНОВЛЕННЫЕ ПАТОФИЗИОЛОГИЯ И ПРОГНОЗ

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Аннотация

Полиорганная недостаточность (ПОН) является ведущей причиной госпитализации пациентов в отделения реанимации. Актуальность проблемы связана с сохраняющимся уровнем летальности и финансовым затратами на лечение подобной категории пациентов. В обзоре даются современные представления об уточнениях в механизмах формирования ПОН в педиатрии (инициирующие факторы, фоновая патология, выброс DAMP и PAMP, в том числе и вероятность транслокации бактерий, дисфункции эпителия, эндотелия, митохондрий, иммунологического ответа). Приводятся данные о шкалах прогноза и диагностики ПОН в педиатрии.

Об авторах

Е. О. Петрова
ФГБОУ ВО «Кемеровский государственный медицинский университет» Минздрава России
Россия


Е. В. Григорьев
ФГБНУ «НИИ комплексных проблем сердечно-сосудистых заболеваний»
Россия


Список литературы

1. Tamburro RF, Jenkins Tammara L. Multiple Organ Dysfunction Syndrome: A Challenge for the Pediatric Critical Care Community. Pediatr Crit Care Med. 2017; 18:S1-S3.

2. Wilkinson JD, Pollack MM, Ruttimann UE, Glass NL, Yeh TS. Outcome of pediatric patients with multiple organ system failure. Crit Care Med. 1986; 14(4): 271-274.

3. Tantaleán JA, León RJ, Santos AA. Multiple organ dysfunction syndrome in children. Pediatr Crit Care Med. 2003; 4:181-185.

4. Proulx F, Joyal JS, Mariscalco MM, Leteurtre S, Leclerc F, Lacroix J. The pediatric multiple organ dysfunction syndrome. Pediatr Crit Care Med. 2009; 10(1): 12-22.

5. Typpo KV, Petersen NJ, Hallman DM. Day 1 multiple organ dysfunction syndrome is associated with poor functional outcome and mortality in the pediatric intensive care unit. Pediatr Crit Care Med. 2009; 10:562-570.

6. Kallinen O, Maisniemi K, Bohling T, et al. Multiple organ failure as a cause of death in patients with severe burns. J Burn Care Res. 2012; 33:206-212.

7. Baue AE. Multiple, progressive, or sequential systems failure. A syndrome of the 1970s. Arch Surg. 1975; 110:779-781.

8. Baue AE. Recovery from multiple organ failure. Am J Surg. 1985; 149:420-421.

9. Baue AE. MOF/MODS, SIRS: An update. Shock. 1996; 6 (Suppl 1): S1-S5.

10. Faa G, Fanni D, Gerosa C, Nemolato S, Faa A, Obinu E. Multiple organ failure syndrome in the newborn: morphological and immunohistochemical data. J Matern Fetal Neonatal Med. 2012; 25(Suppl 5): 68-71.

11. Bestati N, Leteurtre S, Duhamel A, Proulx F, Grandbastien B, Lacroix J, et al. Differences in organ dysfunctions between neonates and older children: a prospective, observational, multicenter study. Crit Care. 2010; 14(6): R202.

12. Leclerc F, Leteurtre S, Duhamel A. Cumulative influence of organ dysfunctions and septic state on mortality of critically ill children. Am J Respir Crit Care Med. 2005; 171:348-353.

13. Carcillo JA., Podd B, Aneja R, Weiss SL, Hall MW. Pathophysiology of Pediatric Multiple Organ Dysfunction Syndrome. Pediatr Crit Care Med. 2017; 18:S32-S45.

14. Csaicsich D, Russo-Schlaff N, Messerschmidt A, Weninger M, Pollak A, Aufricht C. Renal failure, comorbidity and mortality in preterm infants. Wien Klin Wochenchr. 2008; 120(5-6): 153-157.

15. Goldstein B, Giroir B, Randolph A. International pediatric sepsis consensus conference: Definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005; 6:2-8.

16. Weiss SL, Fitzgerald JC, Pappachan J, Wheeler D, Jaramillo-Bustamante JC, Salloo A for the Sepsis Prevalence, Outcomes, and Therapies (SPROUT) Study Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Global Epidemiology of Pediatric Severe Sepsis: The Sepsis Prevalence, Outcomes, and Therapies Study. Am J Respir Crit Care Med. 2015; 191(10): 1147-1157.

17. Watson RS, Crow SS., Hartman ME., Lacroix J, Odetola FO. Epidemiology and Outcomes of Pediatric Multiple Organ Dysfunction Syndrome. Pediatr Crit Care Med. 2017; 18:S4-S16.

18. Hartman ME, Linde-Zwirble WT, Angus DC, Watson RS. Trends in the epidemiology of pediatric severe sepsis. Pediatr Crit Care Med. 2013; 14:686-693.

19. Proulx F, Joyal JS, Mariscalco MM, Leteurtre S, Leclerc F, Lacroix J. The pediatric multiple organ dysfunction syndrome. Pediatr Crit Care Med. 2009;10:12-22.

20. Shapiro N, Howell MD, Bates DW, Angus DC, Ngo L, Talmor D. The association of sepsis syndrome and organ dysfunction with mortality in emergency department patients with suspected infection. Ann Emerg Med. 2006; 48(5): 583-590.

21. Proulx F, Fayon M, Farrell CA. Epidemiology of sepsis and multiple organ dysfunction syndrome in children. Chest. 1996; 109:1033-1037.

22. Carvalho PR, Feldens L, Seitz EE, Rocha TS, Soledade MA, Trotta EA. Prevalence of systemic inflammatory syndromes at a tertiary pediatric intensive care unit. J Pediatr (Rio J). 2005; 81(2): 143-148.

23. Farris RW, Weiss NS, Zimmerman JJ. Functional outcomes in pediatric severe sepsis: further analysis of the researching severe sepsis and organ dysfunction in children: a global perspective trial. Pediatr Crit Care Med. 2013;14:835-842

24. Wynn J, Cornell TT, Wong HR, Shanley TP, Wheeler DS. The Host Response to Sepsis and Developmental Impact. Pediatrics. 2010; 125(5): 1031-1041.

25. Despond O, Proulx F, Carcillo JA. Pediatric sepsis and multiple organ dysfunction syndrome. Curr Opin Pediatr. 2001; 13:247-253.

26. Goldstein B, Giroir B, Randolph A; International Consensus Conference on Pediatric Sepsis. International Pediatric Sepsis Consensus Conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005; 6: 2-8.

27. Weiss SL, Cvijanovich NZ, Allen GL. Differential expression of the nuclear-encoded mitochondrial transcriptome in pediatric septic shock. Crit Care. 2014; 18:623.

28. Hall MW, Knatz NL, Vetterly C, Tomarello S, Wewers MD, Volk HD, Carcillo JA. Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome. Intensive Care Med. 2011; 37:525-532.

29. De Backer D, Ospina-Tascon G, Salgado D, Favory R, Creteur J, Vincent JL. Monitoring the microcirculation in the critically ill patient: current methods and future approaches. Intensive Care Med. 2010; 36:1813-1825.

30. Croner RS, Hoerer E, Kulu Y, Hackert T, Gebhard MM, Herfarth C, Klar E. Hepatic platelet and leukocyte adherence during endotoxemia. Crit Care. 2006; 10:R15.

31. Secor D, Li F, Ellis CG, Sharpe MD, Gross PL, Wilson JX, Tyml K. Impaired microvascular perfusion in sepsis requires activated coagulation and P-selectin-mediated platelet adhesion in capillaries. Intensive Care Med. 2010; 36:1928-1934.

32. Verdant CL, De Backer D, Bruhn A, Clausi C, Su F, Wang Z, Rodriguez H, Pries AR, Vincent JL. Evaluation of sublingual and gut mucosal microcirculation in sepsis: a quantitative analysis. Crit Care Med. 2009; 37:2875-2881.

33. Mella C, Suarez-Arrabal MC, Lopez S. Innate immune dysfunction is associated with enhanced disease severity in infants with severe respiratory syncytial virus bronchiolitis. J Infect Dis. 2013; 207:564-573.

34. Leteurtre S, Martinot A, Duhamel A, Proulx F, Grandbastien B, Cotting J, Gottesman R, Joffe A, Pfenninger J, Hubert P, Lacroix J, Leclerc F. Validation of the paediatric logistic organ dysfunction (PELOD) score: prospective, observational, multicentre study. Lancet, 2003; 362 (9379):192-197.


Для цитирования:


Петрова Е.О., Григорьев Е.В. ПОЛИОРГАННАЯ НЕДОСТАТОЧНОСТЬ В ПРАКТИКЕ ПЕДИАТРИЧЕСКОЙ РЕАНИМАТОЛОГИИ: ОБНОВЛЕННЫЕ ПАТОФИЗИОЛОГИЯ И ПРОГНОЗ. Фундаментальная и клиническая медицина. 2017;2(3):82-87.

For citation:


Petrova E.O., Grigoriev E.V. MULTIPLE ORGAN FAILURE IN PEDIATRIC CRITICAL CARE: ADVANCES IN PATHOPHYSIOLOGY AND PROGNOSIS. Fundamental and Clinical Medicine. 2017;2(3):82-87. (In Russ.)

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