ПОЛИОРГАННАЯ НЕДОСТАТОЧНОСТЬ В ПРАКТИКЕ ПЕДИАТРИЧЕСКОЙ РЕАНИМАТОЛОГИИ: ОБНОВЛЕННЫЕ ПАТОФИЗИОЛОГИЯ И ПРОГНОЗ
Аннотация
Полиорганная недостаточность (ПОН) является ведущей причиной госпитализации пациентов в отделения реанимации. Актуальность проблемы связана с сохраняющимся уровнем летальности и финансовым затратами на лечение подобной категории пациентов. В обзоре даются современные представления об уточнениях в механизмах формирования ПОН в педиатрии (инициирующие факторы, фоновая патология, выброс DAMP и PAMP, в том числе и вероятность транслокации бактерий, дисфункции эпителия, эндотелия, митохондрий, иммунологического ответа). Приводятся данные о шкалах прогноза и диагностики ПОН в педиатрии.
Об авторах
Е. О. Петрова
ФГБОУ ВО «Кемеровский государственный медицинский университет» Минздрава России
Россия
Россия
Е. В. Григорьев
ФГБНУ «НИИ комплексных проблем сердечно-сосудистых заболеваний»
Россия
Россия
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Рецензия
Для цитирования:
Петрова Е.О., Григорьев Е.В. ПОЛИОРГАННАЯ НЕДОСТАТОЧНОСТЬ В ПРАКТИКЕ ПЕДИАТРИЧЕСКОЙ РЕАНИМАТОЛОГИИ: ОБНОВЛЕННЫЕ ПАТОФИЗИОЛОГИЯ И ПРОГНОЗ. Фундаментальная и клиническая медицина. 2017;2(3):82-87.
For citation:
Petrova E.O., Grigoriev E.V. MULTIPLE ORGAN FAILURE IN PEDIATRIC CRITICAL CARE: ADVANCES IN PATHOPHYSIOLOGY AND PROGNOSIS. Fundamental and Clinical Medicine. 2017;2(3):82-87. (In Russ.)
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