Clinical associations of joint hypermobility with other manifestations of undifferentiated connective tissue dysplasia
https://doi.org/10.23946/2500-0764-2026-11-1-37-47
Abstract
Аim. To study the prevalence and structure of undifferentiated connective tissue dysplasia (UCTD) and joint hypermobility syndrome (JHS) in the Transnistrian population.
Materials and methods. 234 outpatients (68.4 % women, median age 49 [IQR 32;63] years) with ≥ 2 chronic diseases were examined. The information was collected through direct examination of the patients, use of the questionnaire, and the analysis of medical documents. UCTD was diagnosed with the involvement of ≥ 2 systems according to the Yakovlev’s criteria; Beighton score ≥ 4 was considered as JHS. p < 0.05 was considered significant.
Results. Signs of UCTD were observed in 53 %, JHS – in 9.4 %. The disorders of musculoskeletal system (58.1 %), gastrointestinal tract (GIT) (32.5 %), eyes (20.5 %) and skin (20.5 %) were the most common signs of UCTD. Involvement of 2 systems was observed in 30.6 %, 3– in 33.9 %, 4 – in 24.2%, ≥ 5–in 11.3 %. Patients with UCTD more often had back pain (p < 0.001). Women more often had signs of UCTD in the skin/muscles (p = 0.043) and nervous system (NS) (p=0.024); people under 60 years of age compared with the elderly, more often had changes in NS (p = 0.043) and cardiovascular system (p < 0.001). Group with JHS, compared with the group without JHS, more often had musculoskeletal and eye signs of UCTD (p < 0.001) and less often – symptoms from GIT (p = 0.014).
Conclusion. In outpatients in Transnistria, undifferentiated UCTD is widespread and characterized by a variety of clinical manifestations, gender and age heterogeneity, with a predominance of musculoskeletal disorders. JHS is more often diagnosed in women under 50 years of age with other manifestations of UCTD. No associations between presence of JHS and other musculoskeletal diseases have been identified.
About the Authors
Y. I. Covbasiuc
Patrice Lumumba Peoples' Friendship University of Russia
Russian Federation
Russian Federation
Dr, Yana I. Covbasiuc, MD, Postgraduate student, Department of Internal Medicine with the Course in Cardiology and Functional Diagnostics Named After V. S. Moisseev, Institute of Clinical medicine, Medical Institute
Miklukho-Maklaya Street, 6, Moscow, 117198
E. A. Troitskaya
Patrice Lumumba Peoples' Friendship University of Russia
Russian Federation
Russian Federation
Dr. Elena A. Troitskaya, MD, Cand. Sci. (Medicine), Associate Professor, Department of Internal Medicine with the Course in Cardiology and Functional Diagnostics Named After V. S. Moisseev, Institute of Clinical medicine, Medical Institute
Miklukho-Maklaya Street, 6, Moscow, 117198
Zh. D. Kobalava
Patrice Lumumba Peoples' Friendship University of Russia
Russian Federation
Russian Federation
Prof. Zhanna D. Kobalava, MD, Dr. Sci. (Medicine), Professor, Corresponding Member of Russian Academy of Sciences, Head of the Department of Internal Medicine with the Course in Cardiology and Functional Diagnostics Named After V. S. Moisseev, Director of the Institute of Clinical medicine, Medical Institute
Miklukho-Maklaya Street, 6, Moscow, 117198
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For citations:
Covbasiuc Y.I., Troitskaya E.A., Kobalava Zh.D. Clinical associations of joint hypermobility with other manifestations of undifferentiated connective tissue dysplasia. Fundamental and Clinical Medicine. 2026;11(1):37-47. (In Russ.) https://doi.org/10.23946/2500-0764-2026-11-1-37-47
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