Treatment for Familial Hereditary Breast Cancer
https://doi.org/10.23946/2500-0764-2026-11-1-111-119
Abstract
The patient with confirmed hereditary cancer risk was admitted to the A.V. Vishnevsky National Medical Research Center of Surgery. A comprehensive genetic analysis revealed heterozygous germline mutation, located in coding exon 10 of the BRCA2 gene, associated with breast-ovarian cancer. Considering the patient’s young age, the cancer team referred her on immediate breast reconstruction after skin-preserving mastectomy. Histological examinations did not reveal any pathological changes indicative of malignant transformation. This case report emphasizes the significance of personalized treatment approach aimed at preventing BRCA-associated breast cancer in patients carrying hereditary mutations. Preventive surgery substantially reduces the risk of cancer, even in patients with genetically determined risks, and ensures a high quality of life.
About the Authors
N. Y. Germanovich
A.V. Vishnevsky National Medical Research Center of Surgery
Russian Federation
Russian Federation
Dr. Natalia Y. Germanovich, MD, Cand. Sci. (Medicine), Surgeon, Oncologist, Head of the Department of Mammalogy and Comorbid Pathology
Bolshaya Serpukhovskaya Street, 27, Moscow, 117997
R. Sh. Tinaeva
A.V. Vishnevsky National Medical Research Center of Surgery
Russian Federation
Russian Federation
Dr. Riana Sh. Tinaeva, MD, сlinical Resident
Bolshaya Serpukhovskaya Street, 27, Moscow, 117997
I. M. Mishchenko
A.V. Vishnevsky National Medical Research Center of Surgery
Russian Federation
Russian Federation
Dr. Inna M. Mishchenko, MD, surgeon, oncologist at the Department of Mammalogy and Comorbid Pathology
Bolshaya Serpukhovskaya Street, 27, Moscow, 117997
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Review
For citations:
Germanovich N.Y., Tinaeva R.Sh., Mishchenko I.M. Treatment for Familial Hereditary Breast Cancer. Fundamental and Clinical Medicine. 2026;11(1):111-119. (In Russ.) https://doi.org/10.23946/2500-0764-2026-11-1-111-119
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