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ANTI-MULLERIAN HORMONE AND ULTRASOUND PARAMETERS IN WOMEN WITH POLYCYSTIC OVARY SYNDROME

Abstract

Aim. To study the ovarian reserve in women of reproductive age with polycystic ovary syndrome (PCOS). Materials and Methods. We recruited 200 women of reproductive age with and without PCOS (n = 100 per group) and performed a comprehensive clinical, gynecological, laboratory, and ultrasound examination. Results. We found that 53% women had a major (A) polycystic ovary syndrome phenotype. Anti-Mullerian hormone (AMH) index was high in women with main (A) and non-androgenic (D) PCOS phenotypes but within the reference values in those with anovulatory (B) and ovulatory (C) phenotypes and healthy women. Ultrasound parameters of the ovaries in women with main (A), ovulatory (C) and non-androgenic (D) PCOS phenotypes were significantly higher compared to those with anovulatory (B) phenotype and healthy women. Conclusions. Ovarian reserve in women of reproductive age with PCOS significantly differs between its phenotypes and as compared to healthy women.

About the Authors

ANZHELIKA Y. Beglova
Kemerovo State Medical University
Russian Federation


SVETLANA I. Elgina
Kemerovo State Medical University
Russian Federation


LYUBOV B. Nikolaeva
Kuzbass Cardiology Сenter
Russian Federation


TATYANA V. Lebedeva
Kemerovo Clinical Consulting and Diagnostic Center
Russian Federation


References

1. Yildiz BO. Polycystic ovary syndrome: is obesity a symptom? Women’s Health. 2013; 9: 505-507. doi: 10.2217/whe.13.53

2. Legro RS, Arslanian SA, Ehrmann DA, Hoeger KM, Murad MH, Pasquali R, et al. Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. Journal of Clinical Endocrinology and Metabolism. 2013; 98 (12): 4565-4592. doi: 10.1210/jc.2013-2350

3. Somani N, Turvy D. Hirsutism: an evidence-based treatment update. Am J Clin Dermatol. 2014; 15 (3): 247-266. doi: 10.1007/s40257-014-0078-4

4. De Leo V, Musacchio MC, Cappelli V, Massaro MG, Morgante G, Petraglia F. Genetic, hormonal and metabolic aspects of PCOS: an update. Reprod Biol Endocrinol. 2016; 14 (1): 38. doi: 10.1186/s12958-016-0173-x

5. Dumesic DA, Oberfield SE, Stener-Victorin E, Marshall JS, Legro RS. Scientific Statement on the Diagnostic Criteria, Epidemiology, Pathophysiology, and Molecular Genetics of Polycystic Ovary Syndrome. Endocr Rev. 2015; 36 (5): 487-525. doi: 10.1210/er.2015-1018

6. Адамян Л.В., Андреева Е.Н., Гаспарян С.А., Геворкян М.А., Григорян О.Р., Гриняева Е.Н. и др. Синдром поликистозных яичников в репродуктивном возрасте (современные подходы к диагностике и лечению): клинические рекомендации (протокол лечения) / Минздрав Российской Федерации. Москва, 2015. C. 22

7. Клинические рекомендации: cиндром поликистоза яичников. Одобрены Российской ассоциацией эндокринологов и Российским обществом акушеров-гинекологов Год утверждения (частота пересмотра): 2016

8. Butterworth J, Deguara J, Borg CM. Bariatric Surgery, Polycystic Ovary Syndrome, and Infertilily. J Obes. 2016; 2016: 1871594. doi: 10.1155/2016/1871594

9. Conway G, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Franks S, Gambineri A, et al. The Polycystic ovary syndrome. A position statement from the European soci-ety of endocrinology. Eur J Endocrinol. 2014; 171 (4): P1-29. doi: 10.1530/EJE-14-0253

10. Rosenfield RL, Ehrmann DA. The Pathogenesis of Polycystic Ovary Syndrome (PCOS): The Hypothesis of PCOS as Functional Ovarian Hyperandrogenism Revisited. Endocr Rev. 2016; 37 (5): 467-520. doi: 10.1210/er.2015-1104

11. Lizneva D, Suturina L, Walker W, Brakta S, Gavrilova-Jordan L, Azziz R. Criteria, prevalence, and phenotypes of polycystic ovary syndrome. Fertil Steril. 2006; 106 (1): 6-15. doi.org/10.23736/S0391-1977.18.02824-9

12. Joham AE, Palomba S, Hart R. Polycystic Ovary Syndrome, Obesity, and Pregnancy. Endocr Rev. 2016; 34 (2): 93-101. doi: 10.1055/s-0035-1571195

13. Bani Mohammad M, Majdi Seghinsara A. Polycystic Ovary Syndrome (PCOS), Diagnostic Criteria and AMH. Asian Pac J Cancer Prev. 2017; 18 (1): 17-21. doi: 10.22034/AP-JCP.2017.18.1.17

14. Гоготадзе И. Н., Федорова А. И. Синдром поликистозных яичников в практике подросткового гинеколога: возможности профилактики, принципы терапии // Гинекология. 2017. Т. 19, № 2. С. 23-27

15. Дубровина С. О. Синдром поликистозных яичников: современный обзор // Гинекология. 2016. Т. 18, № 5. С. 14-17

16. Назаренко Е.А. Стимуляция функции яичников. 4-е изд. Москва: МЕДпресс-информ, 2013. 272 c

17. Захаров И.С., Букреева Е.Л. Оксидативный стресс при синдроме поликистозных яичников: прогностическое значение, возможности коррекции // Гинекология. 2018. Т. 20, № 1. С. 35-38


Review

For citations:


Beglova A.Y., Elgina S.I., Nikolaeva L.B., Lebedeva T.V. ANTI-MULLERIAN HORMONE AND ULTRASOUND PARAMETERS IN WOMEN WITH POLYCYSTIC OVARY SYNDROME. Fundamental and Clinical Medicine. 2019;4(1):29-39. (In Russ.)

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ISSN 2500-0764 (Print)
ISSN 2542-0941 (Online)