THE ROLE OF MATERNAL AND PATERNAL HLA-DRB1* IN CONGENITAL HEART DISEASE OF THEIR CHILDREN
Abstract
Aim. To study the associations of the maternal and paternal alleles and genotypes within the HLA-DRB1* gene with the risk of congenital heart diseases (CHD) in their children. Materials and Methods. Having performed the genotyping, we compared the allele frequencies and genotypes within the HLA-DRB1* in females (experimental group 1, n = 97) and males (experimental group 2, n = 59) who have children with CHD and in females (control group, n = 54) and males (control group 2, n = 98) with healthy children. Results. HLA-DRB1*03 (OR = 5.56) and HLA-DRB1*11 (OR = 4.31) alleles in females along with HLA-DRB1*07 (OR=2.72) allele and HLA-DRB1*01, 04 (OR=15.81) genotype in males were associated with a high risk of CHD. On the contrary, allele HLA-DRB1*12 (OR = 0.28) and HLA- DRB1*01, 12 genotype (OR = 0.06) in females correlated with a lower CHD risk. Conclusions. Inherited variation within the HLA-DRB1* gene is associated with a high risk of CHD in the next generation.
About the Authors
ANDREY V. Shabaldin
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
ANNA V. Tsepokina
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
SVETLANA A. Shmulevich
Kemerovo Cardiology Dispensary
Russian Federation
Russian Federation
ANASTASIA V. Ponasenko
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
LYUDMILA N. Igisheva
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
ELENA V. Shabaldina
Kemerovo State Medical University
Russian Federation
Russian Federation
OLGA V. Sterzhanova
Children's Regional Clinical Hospital
Russian Federation
Russian Federation
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Review
For citations:
Shabaldin A.V., Tsepokina A.V., Shmulevich S.A., Ponasenko A.V., Igisheva L.N., Shabaldina E.V., Sterzhanova O.V. THE ROLE OF MATERNAL AND PATERNAL HLA-DRB1* IN CONGENITAL HEART DISEASE OF THEIR CHILDREN. Fundamental and Clinical Medicine. 2017;2(1):35-43. (In Russ.)
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